Acetate modulates the inhibitory effect of Lactobacillus gasseri against the pathogenic yeasts Candida albicans and Candida glabrata [0.03%]
丙酸盐调节Lactobacillus gasseri对病原性酵母Candida albicans和Candida glabrata的抑制作用
Nuno A Pedro,Gabriela Fontebasso,Sandra N Pinto et al.
Nuno A Pedro et al.
The exploration of the interference prompted by commensal bacteria over fungal pathogens is an interesting alternative to develop new therapies. In this work we scrutinized how the presence of the poorly studied vaginal species Lactobacillu...
A modular cloning (MoClo) toolkit for reliable intracellular protein targeting in the yeast Saccharomyces cerevisiae [0.03%]
一种用于酵母细胞内蛋白质定位的模块化克隆工具包
Pavel Simakin,Christian Koch,Johannes M Herrmann
Pavel Simakin
Modular Cloning (MoClo) allows the combinatorial assembly of plasmids from standardized genetic parts without the need of error-prone PCR reactions. It is a very powerful strategy which enables highly flexible expression patterns without th...
D-Serine reduces the expression of the cytopathic genotoxin colibactin [0.03%]
D--serine通过抑制细胞毒性致突变物质colibactin的表达降低肠上皮细胞损伤
Jennifer C Hallam,Sofia Sandalli,Iris Floria et al.
Jennifer C Hallam et al.
Some Escherichia coli strains harbour the pks island, a 54 kb genomic island encoding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chromosomal...
The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota [0.03%]
乳酸菌的代谢产物：分类、生物合成及其对肠道菌群的调节作用
Huang Tang,Wanqiu Huang,Yu-Feng Yao
Huang Tang
Lactic acid bacteria (LAB) are ubiquitous microorganisms that can colonize the intestine and participate in the physiological metabolism of the host. LAB can produce a variety of metabolites, including organic acids, bacteriocin, amino acid...
The first taxonomic and functional characterization of human CAVD-associated microbiota [0.03%]
人类CAVD相关微生物群的首次分类和功能特征研究
Lavinia Curini,Brunilda Alushi,Mary Roxana Christopher et al.
Lavinia Curini et al.
Introduction: Calcific aortic valve disease (CAVD) is the most common heart valve disorder, defined by a remodeling multistep process: namely, valve fibrosis with its area narrowing, impaired blood flow, and final calcifi...
The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes [0.03%]
非洲锥虫获得外源物质过程中75号不变表膜糖蛋白的作用机制研究
Alexandr Makarov,Jakub Began,Ileana Corvo Mautone et al.
Alexandr Makarov et al.
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion. Several receptors involved in nutrient uptake and defence from the ...
Cellular cholesterol licenses Legionella pneumophila intracellular replication in macrophages [0.03%]
细胞胆固醇许可军团菌在巨噬细胞内的复制
Edna Ondari,Ashley Wilkins,Brian Latimer et al.
Edna Ondari et al.
Host membranes are inherently critical for niche homeostasis of vacuolar pathogens. Thus, intracellular bacteria frequently encode the capacity to regulate host lipogenesis as well as to modulate the lipid composition of host membranes. One...
Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy [0.03%]
肠道微生物群对雄激素剥夺治疗前列腺癌的影响
Safae Terrisse,Laurence Zitvogel,Guido Kroemer
Safae Terrisse
Prostate cancer (PC) can be kept in check by androgen deprivation therapy (ADT, usually with the androgen synthesis inhibitor abiraterone acetate or the androgen receptor antagonist such as enzalutamide) until the tumor evolves to castratio...
DadY (PA5303) is required for fitness of Pseudomonas aeruginosa when growth is dependent on alanine catabolism [0.03%]
爸爸Y(PA5303)是当依赖丙氨酸分解代谢生长时铜绿假单胞菌健康所需的要素
Ronnie L Fulton,Diana M Downs
Ronnie L Fulton
Pseudomonas aeruginosa inhabits diverse environmental niches that can have varying nutrient composition. The ubiquity of this organism is facilitated by a metabolic strategy that preferentially utilizes low-energy, non-fermentable organic a...
Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants [0.03%]
对光滑念珠菌临床分离株的多基因组分析为遗传多样性和抗药性决定因素提供了新见解
Pedro Pais,Mónica Galocha,Azusa Takahashi-Nakaguchi et al.
Pedro Pais et al.
The emergence of drug resistance significantly hampers the treatment of human infections, including those caused by fungal pathogens such as Candida species. Candida glabrata ranks as the second most common cause of candidiasis worldwide, s...