Swimming faster despite obstacles: a universal mechanism behind bacterial speed enhancement in complex fluids [0.03%]
克服困难更快游泳：复杂流体中细菌速度提升的普适机制
Shashank Kamdar,Xiang Cheng
Shashank Kamdar
Bacteria constitute about 15% of global biomass and their natural environments often contain polymers and colloids, which show complex flow behaviors. It is crucial to study their motion in such environments to understand their growth and s...
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens [0.03%]
窄谱抗生素靶向细菌病原体的设计路线图
Xinyun Cao,Robert Landick,Elizabeth A Campbell
Xinyun Cao
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective...
Investigating the role of G-quadruplexes at Saccharomyces cerevisiae telomeres [0.03%]
酵母端粒G-四链体的作用研究
Sonia Stinus,Fernando R Rosas Bringas,Lisa Wanders et al.
Sonia Stinus et al.
The G-quadruplex consensus motif G≥3NxG≥3NxG≥3NxG≥3 is found at telomeres of many species, ranging from yeast to plants to humans, but the biological significance of this fact remains largely unknown. In this study, we examine the in vi...
Breaking the clip for cargo unloading from motor proteins: mechanism and significance [0.03%]
电机蛋白货运卸载的“破剪”机制及其意义
Keisuke Obara,Takumi Kamura
Keisuke Obara
The mitochondrion is an essential organelle involved in ATP generation, lipid metabolism, regulation of calcium ions, etc. Therefore, it should be inherited properly by newly generated cells. In the budding yeast Saccharomyces cerevisiae, m...
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword [0.03%]
结核分枝杆菌的脂肪酸代谢：双刃剑效应
Camila G Quinonez,Jae Jin Lee,Juhyeon Lim et al.
Camila G Quinonez et al.
Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host's fatty acids as a main carbo...
Air- and dustborne fungi in repositories of the National Archive of the Republic of Cuba [0.03%]
古巴国家档案馆中的空气和灰尘真菌
Sofia Borrego,Isbel Vivar,Alian Molina
Sofia Borrego
This study has as objectives to determine the concentration and diversity of the air- and dustborne mycobiota in seven National Archive of the Republic of Cuba repositories, and to assess the potential risk of biodeterioration that isolated...
Pirates of the haemoglobin [0.03%]
血红蛋白海盗
Daniel Akinbosede,Robert Chizea,Stephen A Hare
Daniel Akinbosede
Not all treasure is silver and gold; for pathogenic bacteria, iron is the most precious and the most pillaged of metallic elements. Iron is essential for the survival and growth of all life; however free iron is scarce for bacteria inside h...
A hundred spotlights on microbiology: how microorganisms shape our lives [0.03%]
聚焦微生物学一百问：微生物如何影响我们的生活
Didac Carmona-Gutierrez,Katharina Kainz,Andreas Zimmermann et al.
Didac Carmona-Gutierrez et al.
Viral, bacterial, fungal and protozoal biology is of cardinal importance for the evolutionary history of life, ecology, biotechnology and infectious diseases. Various microbiological model systems have fundamentally contributed to the under...
Brandon Ho,Raphael Loll-Krippleber,Grant W Brown
Brandon Ho
The budding yeast Saccharomyces cerevisiae has long been an outstanding platform for understanding the biology of eukaryotic cells. Robust genetics, cell biology, molecular biology, and biochemistry complement deep and detailed genome annot...
David M P De Oliveira,Mark J Walker
David M P De Oliveira
Within intensive care units, multi-drug resistant Acinetobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive ventilator support experience a 2-fold ...