Investigation of the acetic acid stress response in Saccharomyces cerevisiae with mutated H3 residues [0.03%]
组蛋白H3变异对酿酒酵母醋酸胁迫响应的影响研究
Nitu Saha,Swati Swagatika,Raghuvir Singh Tomar
Nitu Saha
Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towar...
Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2 [0.03%]
酿酒酵母基因KTI13（同义词DPH8）在翻译延长因子2上泛硫胺合成起始步骤中发挥作用
Meike Arend,Koray Ütkür,Harmen Hawer et al.
Meike Arend et al.
In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthami...
The coenzyme B12 precursor 5,6-dimethylbenzimidazole is a flavin antagonist in Salmonella [0.03%]
一种维生素B12前体物质可对抗沙门氏菌中的另一种重要营养物质
Lahiru Malalasekara,Jorge C Escalante-Semerena
Lahiru Malalasekara
Salmonella enterica subsp. enterica sv. Typhimurium str. LT2 (hereafter S. Typhimurium) synthesizes adenosylcobalamin (AdoCbl, CoB12) de novo only under anoxic conditions, but it can assemble the lower ligand loop (a.k.a. the nucleotide loo...
Metallothionein Cup1 attenuates nitrosative stress in the yeast Saccharomyces cerevisiae [0.03%]
金属硫蛋白Cup1通过减轻类柳胺诱导的亚硝化应激来延长酿酒酵母的寿命
Yuki Yoshikawa,Ryo Nasuno,Naoki Takaya et al.
Yuki Yoshikawa et al.
Metallothionein (MT), which is a small metal-binding protein with cysteine-rich motifs, functions in the detoxification of heavy metals in a variety of organisms. Even though previous studies suggest that MT is involved in the tolerance mec...
Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates [0.03%]
半胱天冬酶3表现出类似芽殖酵母拟半胱天冬酶的蛋白质稳态功能可使线粒体免受TDP43毒性聚集物侵害
Steve Brunette,Anupam Sharma,Ryan Bell et al.
Steve Brunette et al.
Caspase 3 activation is a hallmark of cell death and there is a strong correlation between elevated protease activity and evolving pathology in neurodegenerative disease, such as amyotrophic lateral sclerosis (ALS). At the cellular level, A...
GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureus reveal surface-associated coagulase in biofilms [0.03%]
金黄色葡萄球菌中的Sec转运信号肽融合绿色荧光蛋白体系研究生物膜中表面相关凝血酶的定位及功能
Dominique C S Evans,Amanda B Khamas,Lisbeth Marcussen et al.
Dominique C S Evans et al.
Staphylococcus aureus is a major human pathogen that utilises many surface-associated and secreted proteins to form biofilms and cause disease. However, our understanding of these processes is limited by challenges of using fluorescent prot...
Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli? [0.03%]
核糖5-磷酸：严格响应期间大肠杆菌中核酸和氨基酸代谢之间的关键代谢物？
Paulina Katarzyna Grucela,Tobias Fuhrer,Uwe Sauer et al.
Paulina Katarzyna Grucela et al.
The bacterial stringent response and its effector alarmone guanosine penta- or tetra - phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence)...
TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization [0.03%]
TL-532：一种新型特异性激活TLR3的激动剂设计用于靶向癌症：发现过程和生物学特性分析
Sylvain Thierry,Sarah Maadadi,Aurore Berton et al.
Sylvain Thierry et al.
Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. TLR3 acts also as a death receptor only in cancer...
Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast [0.03%]
自噬关键调控因子Atg1通过促进钙超载应激下的MAPK活化和细胞死亡发挥功能
Teruaki Takasaki,Ryosuke Utsumi,Erika Shimada et al.
Teruaki Takasaki et al.
Autophagy promotes or inhibits cell death depending on the environment and cell type. Our previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 MAPK in fission yeast. Here, we showed that Δatg1 displays lo...
Infinity war: Trichomonas vaginalis and interactions with host immune response [0.03%]
无尽的战争：阴道毛滴虫与宿主免疫反应的相互作用
Giulia Bongiorni Galego,Tiana Tasca
Giulia Bongiorni Galego
Trichomonas vaginalis is the pathological agent of human trichomoniasis. The incidence is 156 million cases worldwide. Due to the increasing resistance of isolates to approved drugs and clinical complications that include increased risk in ...