Expansion of metabolically labelled endocytic organelles and cytoskeletal cell structures in Giardia lamblia using optimised U-ExM protocols [0.03%]
优化的U-ExM协议在Giardia lamblia中扩大代谢标记的内吞小泡和细胞骨架结构
Clirim Jetishi,Erina A Balmer,Bianca M Berger et al.
Clirim Jetishi et al.
Understanding cellular ultrastructure is tightly bound to microscopic resolution and the ability to identify individual components at that resolution. Expansion microscopy has revolutionised this topic. Here we present and compare two proto...
From microbes to medicine: harnessing the gut microbiota to combat prostate cancer [0.03%]
从微生物到医学：利用肠道菌群对抗前列腺癌
Anjali Yadav,Meenakshi Kaushik,Prabhakar Tiwari et al.
Anjali Yadav et al.
The gut microbiome (GM) has been identified as a crucial factor in the development and progression of various diseases, including cancer. In the case of prostate cancer, commensal bacteria and other microbes are found to be associated with ...
A metagenomic approach to unveil the association between fecal gut microbiota and short-chain fatty acids in diarrhea caused by diarrheagenic Escherichia coli in children [0.03%]
采用元基因组学方法揭示儿童由致腹泻性大肠杆菌引起的腹泻粪便菌群与短链脂肪酸之间的关系
Pablo Gallardo,Mariana Izquierdo,Tomeu Viver et al.
Pablo Gallardo et al.
Diarrheagenic Escherichia coli (DEC) is the main cause of diarrhea in children under five years old. The virulence of DEC is tightly regulated by environmental signals influenced by the gut microbiota and its metabolites. Short-chain fatty ...
A Modular Cloning Toolkit for the production of recombinant proteins in Leishmania tarentolae [0.03%]
一种用于正粘病毒重组蛋白在Leishmania tarentolae中生产的模块化克隆工具包
Katrin Hieronimus,Tabea Donauer,Jonas Klein et al.
Katrin Hieronimus et al.
Modular Cloning (MoClo) is based on libraries of standardized genetic parts that can be directionally assembled via Golden Gate cloning in one-pot reactions into transcription units and multigene constructs. Here, a team of bachelor student...
Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome [0.03%]
酿酒酵母中的小非编码RNA的多聚腺苷酸化版本通过Rrp6p / Rrp47p独立于核核心外切酶而降解
Anusha Chaudhuri,Soumita Paul,Mayukh Banerjea et al.
Anusha Chaudhuri et al.
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precursor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3'-end maturation are subject to an active degradation by Rrp6p and Rrp47p, which does not require ...
Exploring carbon source related localization and phosphorylation in the Snf1/Mig1 network using population and single cell-based approaches [0.03%]
利用群体和单细胞方法探索碳源相关的定位及Snf1/Mig1网络中的磷酸化问题
Svenja Braam,Farida Tripodi,Linnea Österberg et al.
Svenja Braam et al.
The AMPK/SNF1 pathway governs energy balance in eukaryotic cells, notably influencing glucose de-repression. In S. cerevisiae, Snf1 is phosphorylated and hence activated upon glucose depletion. This activation is required but is not suffici...
The effect of multiple sclerosis therapy on gut microbiota dysbiosis: a longitudinal prospective study [0.03%]
多发性硬化症治疗对肠道微生物群失调的影响：一项纵向前瞻性研究
Andreea-Cristina Paraschiv,Vitalie Vacaras,Cristina Nistor et al.
Andreea-Cristina Paraschiv et al.
Gut microbiota has complex immune functions, related to different pathologies, including multiple sclerosis (MS).This study evaluated the influence of treatments on gut microbiota in people with MS (PwMS). The research comprised 60 particip...
The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress [0.03%]
cAMP-PKA信号在酵母细胞响应渗透压和热应力中与CWI和HOG-MAPK通路的相互作用
Fiorella Galello,Mariana Bermúdez-Moretti,María Clara Ortolá Martínez et al.
Fiorella Galello et al.
The yeast Saccharomyces cerevisiae is widely used in food and non-food industries. During industrial fermentation yeast strains are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient avail...
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study [0.03%]
溃疡性结肠炎患者中微生物群系和硫酸盐还原菌的比例及其与肠道疾病的关联性：初步研究
Ivan Kushkevych,Kristýna Martínková,Lenka Mráková et al.
Ivan Kushkevych et al.
Considerable evidence has accumulated regarding the molecular relationship between gut microbiota (GM) composition and the onset (clinical presentation and prognosis of ulcerative colitis (UC)). In addition, it is well documented that short...
Replicative aging in yeast involves dynamic intron retention patterns associated with mRNA processing/export and protein ubiquitination [0.03%]
酵母的复制衰老涉及与mRNA加工/转运和蛋白质泛素化相关的动态内含子滞留模式
Jesús Gómez-Montalvo,Alvaro de Obeso Fernández Del Valle,Luis Fernando De la Cruz Gutiérrez et al.
Jesús Gómez-Montalvo et al.
Saccharomyces cerevisiae (baker's yeast) has yielded relevant insights into some of the basic mechanisms of organismal aging. Among these are genomic instability, oxidative stress, caloric restriction and mitochondrial dysfunction. Several ...