Polyadenylated versions of small non-coding RNAs in Saccharomyces cerevisiae are degraded by Rrp6p/Rrp47p independent of the core nuclear exosome [0.03%]
酿酒酵母中的小非编码RNA的多聚腺苷酸化版本通过Rrp6p / Rrp47p独立于核核心外切酶而降解
Anusha Chaudhuri,Soumita Paul,Mayukh Banerjea et al.
Anusha Chaudhuri et al.
In Saccharomyces cerevisiae, polyadenylated forms of mature (and not precursor) small non-coding RNAs (sncRNAs) those fail to undergo proper 3'-end maturation are subject to an active degradation by Rrp6p and Rrp47p, which does not require ...
Exploring carbon source related localization and phosphorylation in the Snf1/Mig1 network using population and single cell-based approaches [0.03%]
利用群体和单细胞方法探索碳源相关的定位及Snf1/Mig1网络中的磷酸化问题
Svenja Braam,Farida Tripodi,Linnea Österberg et al.
Svenja Braam et al.
The AMPK/SNF1 pathway governs energy balance in eukaryotic cells, notably influencing glucose de-repression. In S. cerevisiae, Snf1 is phosphorylated and hence activated upon glucose depletion. This activation is required but is not suffici...
The effect of multiple sclerosis therapy on gut microbiota dysbiosis: a longitudinal prospective study [0.03%]
多发性硬化症治疗对肠道微生物群失调的影响：一项纵向前瞻性研究
Andreea-Cristina Paraschiv,Vitalie Vacaras,Cristina Nistor et al.
Andreea-Cristina Paraschiv et al.
Gut microbiota has complex immune functions, related to different pathologies, including multiple sclerosis (MS).This study evaluated the influence of treatments on gut microbiota in people with MS (PwMS). The research comprised 60 particip...
The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress [0.03%]
cAMP-PKA信号在酵母细胞响应渗透压和热应力中与CWI和HOG-MAPK通路的相互作用
Fiorella Galello,Mariana Bermúdez-Moretti,María Clara Ortolá Martínez et al.
Fiorella Galello et al.
The yeast Saccharomyces cerevisiae is widely used in food and non-food industries. During industrial fermentation yeast strains are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient avail...
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study [0.03%]
溃疡性结肠炎患者中微生物群系和硫酸盐还原菌的比例及其与肠道疾病的关联性：初步研究
Ivan Kushkevych,Kristýna Martínková,Lenka Mráková et al.
Ivan Kushkevych et al.
Considerable evidence has accumulated regarding the molecular relationship between gut microbiota (GM) composition and the onset (clinical presentation and prognosis of ulcerative colitis (UC)). In addition, it is well documented that short...
Replicative aging in yeast involves dynamic intron retention patterns associated with mRNA processing/export and protein ubiquitination [0.03%]
酵母的复制衰老涉及与mRNA加工/转运和蛋白质泛素化相关的动态内含子滞留模式
Jesús Gómez-Montalvo,Alvaro de Obeso Fernández Del Valle,Luis Fernando De la Cruz Gutiérrez et al.
Jesús Gómez-Montalvo et al.
Saccharomyces cerevisiae (baker's yeast) has yielded relevant insights into some of the basic mechanisms of organismal aging. Among these are genomic instability, oxidative stress, caloric restriction and mitochondrial dysfunction. Several ...
Quantifying yeast lipidomics by high-performance thin-layer chromatography (HPTLC) and comparison to mass spectrometry-based shotgun lipidomics [0.03%]
高性能薄层色谱法(HPTLC)定量酵母脂质组学并与基于质谱的枪击脂质组学比较
Thorsten Meyer,Oskar Knittelfelder,Martin Smolnig et al.
Thorsten Meyer et al.
Lipidomic analysis in diverse biological settings has become a frequent tool to increase our understanding of the processes of life. Cellular lipids play important roles not only as being the main components of cellular membranes, but also ...
A cobalt concentration sensitive Btu-like system facilitates cobalamin uptake in Anabaena sp. PCC 7120 [0.03%]
一种类似Btu的系统可促进麻风螺菌PCC 7120对钴胺素的吸收，并且对该系统而言钴的浓度很敏感
Julia Graf,Leonard Fresenborg,Hans-Michael Seitz et al.
Julia Graf et al.
Metal homeostasis is central to all forms of life, as metals are essential micronutrients with toxic effects at elevated levels. Macromolecular machines facilitate metal uptake into the cells and their intracellular level is regulated by mu...
Predictable regulation of survival by intratumoral microbe-immune crosstalk in patients with lung adenocarcinoma [0.03%]
可预测的肿瘤内微生物-免疫相互作用对肺腺癌患者生存率的影响调节
Shuo Shi,Yuwen Chu,Haiyan Liu et al.
Shuo Shi et al.
Intratumoral microbiota can regulate the tumor immune microenvironment (TIME) and mediate tumor prognosis by promoting inflammatory response or inhibiting anti-tumor effects. Recent studies have elucidated the potential role of local tumor ...
Two TonB-dependent outer membrane transporters involved in heme uptake in Anabaena sp. PCC 7120 [0.03%]
蓝藻菌PCC 7120中两种参与血红素吸收的TonB依赖性外膜转运蛋白
Julia Graf,Martin Schöpperle,Rafael Pernil et al.
Julia Graf et al.
Low availability of micronutrients such as iron has enforced the evolution of uptake systems in all kingdoms of life. In Gram-negative bacteria, outer membrane, periplasmatic and plasma membrane localized proteins facilitate the uptake of i...