Patterns of protein synthesis in the budding yeast cell cycle: variable or constant? [0.03%]
芽殖酵母细胞周期中的蛋白质合成模式：变化的还是不变的？
Eun-Gyu No,Heidi M Blank,Michael Polymenis
Eun-Gyu No
Proteins are the principal macromolecular constituent of proliferating cells, and protein synthesis is viewed as a primary metric of cell growth. While there are celebrated examples of proteins whose levels are periodic in the cell cycle (e...
Direct detection of stringent alarmones (pp)pGpp using malachite green [0.03%]
孔雀石绿直接检测严紧报警物(pp)PGpr的做法
Muriel Schicketanz,Magdalena Petrová,Dominik Rejman et al.
Muriel Schicketanz et al.
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on develo...
Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts [0.03%]
了解人类疾病分子机制：裂殖酵母的益处
Lajos Acs-Szabo,Laszlo Attila Papp,Ida Miklos
Lajos Acs-Szabo
The role of model organisms such as yeasts in life science research is crucial. Although the baker's yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the contribution of the fission yeasts (Schizosaccharomyces) to li...
Quantification methods of Candida albicans are independent irrespective of fungal morphology [0.03%]
白色念珠菌的量化方法与其真菌形态无关独立存在
Amanda B Soares,Maria C de Albuquerque,Leticia M Rosa et al.
Amanda B Soares et al.
The ability of Candida albicans to switch its morphology from yeast to filaments, known as polymorphism, may bias the methods used in microbial quantification. Here, we compared the quantification methods [cell/mL, colony forming units (CFU...
Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis [0.03%]
活动性肺结核患者PD-L1启动子高甲基化与PD-L1表达量增加的关系研究
Yen-Han Tseng,Sheng-Wei Pan,Jhong-Ru Huang et al.
Yen-Han Tseng et al.
The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, it...
Pathogenic Escherichia coli change the adhesion between neutrophils and endotheliocytes in the experimental bacteremia model [0.03%]
致病性大肠杆菌在实验菌血症模型中改变中性粒细胞和内皮细胞之间的黏附作用
Svetlana N Pleskova,Nikolay A Bezrukov,Sergey Z Bobyk et al.
Svetlana N Pleskova et al.
Septicemia caused by gram-negative bacteria is characterized by high death rate due to the endotoxin release. Since the septicemia depends not only on biochemical aspects of interactions in the system bloodstream, the study of mechanical in...
Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence [0.03%]
环核苷酸第二信使、周质酸性磷酸酶和细菌天然转化的未解之谜
Kristina Kronborg,Yong Everett Zhang
Kristina Kronborg
We recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutr...
Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast [0.03%]
砷处理在裂殖酵母中诱导HSP90聚集物的形成，不同于常规应激颗粒
Naofumi Tomimoto,Teruaki Takasaki,Reiko Sugiura
Naofumi Tomimoto
Various stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase separation. We have previously shown that Hsp90 forms aggregates in re...
Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention [0.03%]
中和威胁：利用广谱中和抗体防治HIV-1病毒感染
Juan C Becerra,Lauren Hitchcock,Khoa Vu et al.
Juan C Becerra et al.
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine de...
Characterising glycosaminoglycans in human breastmilk and their potential role in infant health [0.03%]
人乳中的糖胺聚糖及其在婴儿健康中潜在作用的特征分析
Melissa Greenwood,Patricia Murciano-Martínez,Janet Berrington et al.
Melissa Greenwood et al.
Human breastmilk is composed of many well researched bioactive components crucial for infant nutrition and priming of the neonatal microbiome and immune system. Understanding these components gives us crucial insight to the health and wellb...