Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis [0.03%]
活动性肺结核患者PD-L1启动子高甲基化与PD-L1表达量增加的关系研究
Yen-Han Tseng,Sheng-Wei Pan,Jhong-Ru Huang et al.
Yen-Han Tseng et al.
The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, it...
Pathogenic Escherichia coli change the adhesion between neutrophils and endotheliocytes in the experimental bacteremia model [0.03%]
致病性大肠杆菌在实验菌血症模型中改变中性粒细胞和内皮细胞之间的黏附作用
Svetlana N Pleskova,Nikolay A Bezrukov,Sergey Z Bobyk et al.
Svetlana N Pleskova et al.
Septicemia caused by gram-negative bacteria is characterized by high death rate due to the endotoxin release. Since the septicemia depends not only on biochemical aspects of interactions in the system bloodstream, the study of mechanical in...
Unresolved mystery of cyclic nucleotide second messengers, periplasmic acid phosphatases and bacterial natural competence [0.03%]
环核苷酸第二信使、周质酸性磷酸酶和细菌天然转化的未解之谜
Kristina Kronborg,Yong Everett Zhang
Kristina Kronborg
We recently characterized the competitive inhibition of cyclic AMP (cAMP) on three periplasmic acid phosphatases, AphAHi, NadNHi, and eP4 (HelHi), in Haemophilus influenzae Rd KW20. This inhibitory effect is vital for orchestrating the nutr...
Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast [0.03%]
砷处理在裂殖酵母中诱导HSP90聚集物的形成，不同于常规应激颗粒
Naofumi Tomimoto,Teruaki Takasaki,Reiko Sugiura
Naofumi Tomimoto
Various stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase separation. We have previously shown that Hsp90 forms aggregates in re...
Neutralizing the threat: harnessing broadly neutralizing antibodies against HIV-1 for treatment and prevention [0.03%]
中和威胁：利用广谱中和抗体防治HIV-1病毒感染
Juan C Becerra,Lauren Hitchcock,Khoa Vu et al.
Juan C Becerra et al.
Broadly neutralizing antibodies (bnAbs) targeting the human immunodeficiency virus-1 (HIV-1) have played a crucial role in elucidating and characterizing neutralization-sensitive sites on the HIV-1 envelope spike and in informing vaccine de...
Characterising glycosaminoglycans in human breastmilk and their potential role in infant health [0.03%]
人乳中的糖胺聚糖及其在婴儿健康中潜在作用的特征分析
Melissa Greenwood,Patricia Murciano-Martínez,Janet Berrington et al.
Melissa Greenwood et al.
Human breastmilk is composed of many well researched bioactive components crucial for infant nutrition and priming of the neonatal microbiome and immune system. Understanding these components gives us crucial insight to the health and wellb...
Expansion of metabolically labelled endocytic organelles and cytoskeletal cell structures in Giardia lamblia using optimised U-ExM protocols [0.03%]
优化的U-ExM协议在Giardia lamblia中扩大代谢标记的内吞小泡和细胞骨架结构
Clirim Jetishi,Erina A Balmer,Bianca M Berger et al.
Clirim Jetishi et al.
Understanding cellular ultrastructure is tightly bound to microscopic resolution and the ability to identify individual components at that resolution. Expansion microscopy has revolutionised this topic. Here we present and compare two proto...
From microbes to medicine: harnessing the gut microbiota to combat prostate cancer [0.03%]
从微生物到医学：利用肠道菌群对抗前列腺癌
Anjali Yadav,Meenakshi Kaushik,Prabhakar Tiwari et al.
Anjali Yadav et al.
The gut microbiome (GM) has been identified as a crucial factor in the development and progression of various diseases, including cancer. In the case of prostate cancer, commensal bacteria and other microbes are found to be associated with ...
A metagenomic approach to unveil the association between fecal gut microbiota and short-chain fatty acids in diarrhea caused by diarrheagenic Escherichia coli in children [0.03%]
采用元基因组学方法揭示儿童由致腹泻性大肠杆菌引起的腹泻粪便菌群与短链脂肪酸之间的关系
Pablo Gallardo,Mariana Izquierdo,Tomeu Viver et al.
Pablo Gallardo et al.
Diarrheagenic Escherichia coli (DEC) is the main cause of diarrhea in children under five years old. The virulence of DEC is tightly regulated by environmental signals influenced by the gut microbiota and its metabolites. Short-chain fatty ...
A Modular Cloning Toolkit for the production of recombinant proteins in Leishmania tarentolae [0.03%]
一种用于正粘病毒重组蛋白在Leishmania tarentolae中生产的模块化克隆工具包
Katrin Hieronimus,Tabea Donauer,Jonas Klein et al.
Katrin Hieronimus et al.
Modular Cloning (MoClo) is based on libraries of standardized genetic parts that can be directionally assembled via Golden Gate cloning in one-pot reactions into transcription units and multigene constructs. Here, a team of bachelor student...