Tumor microenvironment signatures enhances lung adenocarcinoma prognosis prediction: Implication of intratumoral microbiota [0.03%]
肿瘤微环境标志物可增强肺腺癌预后预测：肿瘤内微生物群的启示
Fei Zhao,Lei Wang,Dongjie Du et al.
Fei Zhao et al.
The interaction between intratumoral microbiome and the tumor microenvironment (TME) has furthered our understanding of tumor ecology. Yet, the implications of their interaction for lung cancer management remain unclear. In the current work...
Persistence phenotype of adherent-invasive Escherichia coli in response to ciprofloxacin, revealing high-persistence strains [0.03%]
环丙沙星条件下黏附侵袭型大肠杆菌持续性表型的响应研究及高持续菌株的筛选
Valeria Pérez-Villalobos,Roberto Vidal,Marcela A Hermoso et al.
Valeria Pérez-Villalobos et al.
Persister cells are a subpopulation of bacteria capable of surviving antibiotic treatments and are thought to contribute to disease chronicity and symptom relapse of chronic conditions. Crohn's disease (CD) is a multifactorial chronic infla...
Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi [0.03%]
CRISPR-Cas9敲除组氨酸氨酶消除组氨酸在克查氏原虫生物能量和生活史中的作用
Janaína de Freitas Nascimento,María Julia Barisón,Gabriela Torres Montanaro et al.
Janaína de Freitas Nascimento et al.
Trypanosoma cruzi, the causing agent of Chagas disease, is the only known trypanosomatid pathogenic to humans having a complete histidine to glutamate pathway, which involves a series of four enzymatic reactions that convert histidine into ...
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast [0.03%]
啤酒酵母细胞周期调控、DNA损伤敏感性及咖啡因对寿命影响的研究
John-Patrick Alao,Juhi Kumar,Despina Stamataki et al.
John-Patrick Alao et al.
Caffeine can modulate cell cycle progression, override DNA damage checkpoint signalling and increase chronological lifespan (CLS) in various model systems. Early studies suggested that caffeine inhibits the phosphatidylinositol 3-kinase-rel...
Uga3 influences nitrogen metabolism in Saccharomyces cerevisiae by modulating arginine biosynthesis [0.03%]
UGA3通过调节精氨酸生物合成影响酿酒酵母氮代谢
Nicolás Urtasun,Sebastián Aníbal Muñoz,Martín Arán et al.
Nicolás Urtasun et al.
Nitrogen metabolism in Saccharomyces cerevisiae is tightly regulated to optimize the utilization of available nitrogen sources. Uga3 is a known transcription factor involved in the gamma-aminobutyric acid (GABA) pathway; however, its broade...
An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases [0.03%]
腺嘌呤模型揭示了先天性代谢错误改变了TDP-43聚集并降低其毒性，为蛋白质误折叠疾病提供了见解
Sangeun Park,Sei-Kyoung Park,Peter Blair et al.
Sangeun Park et al.
TDP-43 is linked to human diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Expression of TDP-43 in yeast is known to be toxic, cause cells to elongate, form liquid-like aggregates, and inhibit auto...
Advancements in vaginal microbiota, Trichomonas vaginalis, and vaginal cell interactions: Insights from co-culture assays [0.03%]
阴道微生态、阴道毛滴虫及阴道细胞互作研究进展：共培养检测法的新见解
Fernanda Gomes Cardoso,Tiana Tasca
Fernanda Gomes Cardoso
Vaginal microbiota involves seven communities-state types (CST), four dominated by Lactobacillus. L. crispatus, particularly, offers enhanced protection against infections. Recurrent vulvovaginal candidiasis and trichomoniasis affect millio...
Clostridium scindens promotes gallstone formation by inducing intrahepatic neutrophil extracellular traps through CXCL1 produced by colonic epithelial cells [0.03%]
肠上皮细胞分泌的CXCL1诱导肝内中性粒细胞胞外诱捕网形成从而促进产芽孢杆菌裂解素生成菌所致胆石症发生
Wenchao Yao,Yuanhang He,Zhihong Xie et al.
Wenchao Yao et al.
Cholelithiasis is one of the most common diseases of the biliary system. Neutrophil extracellular traps (NETs) in the liver play an important role in accelerating the formation of gallstones. The upstream mechanism of NETs formation remains...
Microbiota and metabolome dynamics induced by Shiga toxin-producing E. coli in an in vitro model of an infant's colon [0.03%]
一种体外婴儿结肠模型中产生志贺毒素的大肠杆菌引起的微生物组和代谢组变化
Mariana Izquierdo,Deborah O&#x;Sullivan,Ophélie Uriot et al.
Mariana Izquierdo et al.
Shiga toxin-producing Escherichia coli (STEC) is a major food-borne pathogen causing human diseases ranging from diarrhea to life-threatening complications, mainly in young children. Colonization, virulence, and interactions of STEC strains...
Influence of cervicovaginal microbiota on Chlamydia trachomatis infection dynamics [0.03%]
宫颈阴道微生物群对沙眼衣原体感染动态的影响
Emily Hand,Indriati Hood-Pishchany,Toni Darville et al.
Emily Hand et al.
The cervicovaginal microbiome (CVM) is increasingly being considered as an important aspect of women's health, particularly in relation to the risk and progression of sexually transmitted infections (STIs). CVM composition varies significan...