Transcriptomic response to different heme sources in Trypanosoma cruzi epimastigotes [0.03%]
不同血红素来源条件下幽门螺杆菌的转录组应答反应
Evelyn Tevere,María G Mediavilla,Cecilia B Di Capua et al.
Evelyn Tevere et al.
Heme is an essential molecule for most organisms, yet some parasites, like Trypanosoma cruzi, the causative agent of Chagas disease, cannot synthesize it. These parasites must acquire heme from their hosts, making this process critical for ...
Ji-In Ryu,Juhye Jung,Jeong-Yoon Kim
Ji-In Ryu
Autophagy contributes to cellular homeostasis by degrading and recycling intracellular components, especially under nutrient-limited conditions. While autophagy is well characterized under acute starvation in synthetic media in Saccharomyce...
Luminal acetylation of microtubules is not essential for Plasmodium berghei and Toxoplasma gondii survival [0.03%]
恶性疟原虫和刚地弓形虫的管腔乙酰化微管蛋白并非其生存所必需
Thrishla Kumar,Katharina Röver,Johannes F Stortz et al.
Thrishla Kumar et al.
Post-translational modifications of microtubules regulate their stability and dynamics. Acetylation of α tubulin at lysine 40 (K40) by α -acetyltransferase ( α TAT) occurs on the luminal side of microtubules, stabilizes their...
The dual-site agonist for human M2 muscarinic receptors Iper-8-naphtalimide induces mitochondrial dysfunction in Saccharomyces cerevisiae [0.03%]
人M2胆碱能受体双位点激动剂Iper-8-萘酰亚胺通过线粒体功能障碍诱导酿酒酵母细胞死亡
Angela Cirigliano,Antonia Amelina,Elena Passarini et al.
Angela Cirigliano et al.
Glioblastoma is a malignant astrocytic tumor of the brain. A significantly decrease of glioblastoma cell proliferation and survival can be achieved by activating the M2 muscarinic acetylcholine receptor (a G protein-coupled receptor, or GPC...
The core genetic drivers of chronological aging in yeast are universal regulators of longevity [0.03%]
酵母菌株老化的主要遗传驱动因素是长寿的通用调节因子
Erika Cruz-Bonilla,Sergio E Campos,Soledad Funes et al.
Erika Cruz-Bonilla et al.
The chronological lifespan of Saccharomyces cerevisiae has significantly contributed to our understanding of aging in eukaryotic cells. However, gaining a genome-wide perspective of this trait remains challenging due to substantial discrepa...
Organelle activity organized by the endoplasmic reticulum-mitochondria encounter structure -ERMES- is essential for Podospora anserina development [0.03%]
由内质网-线粒体相遇结构（ERMES）组织的细胞器活性对柄刀壳菌发育至关重要
Melisa Álvarez-Sánchez,Matías Ramírez-Noguez,Beatriz Aguirre-López et al.
Melisa Álvarez-Sánchez et al.
Eucaryotic cell functioning and development depend on the concerted activity of its organelles. In the model fungus Podospora anserina, sexual development involves a dynamic regulation of mitochondria, peroxisomes and the endoplasmic reticu...
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae [0.03%]
酿酒酵母线粒体动力学的分子机制及其生理作用
Chang-Lin Chen,Wei-Ling Huang,Alexander Rapoport et al.
Chang-Lin Chen et al.
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic pro...
Alternative splicing drives a dynamic transcriptomic response during Acanthamoeba castellanii programmed cell death [0.03%]
交替剪接驱动卡氏棘阿米巴程序性细胞死亡过程中的转录组动态变化
Jesús Gómez-Montalvo,Zisis Koutsogiannis,Sutherland K Maciver et al.
Jesús Gómez-Montalvo et al.
Programmed cell death (PCD) in unicellular organisms is not well characterized. This study investigated the transcriptomic response of Acanthamoeba castellanii to G418-induced PCD, focusing on the role of alternative splicing (AS). RNA sequ...
Gut microbiota and ankylosing spondylitis: current insights and future challenges [0.03%]
肠道微生物群与强直性脊柱炎：当前见解和未来挑战
Andrei Lobiuc,Liliana Groppa,Lia Chislari et al.
Andrei Lobiuc et al.
Ankylosing spondylitis (AS) is a chronic inflammatory disease with complex pathogenesis influenced by genetic, immunological and environmental factors. Recent evidence suggests that gut microbiota significantly contributes to AS etiopathoge...
Role of the putative sit1 gene in normal germination of spores and virulence of the Mucor lusitanicus [0.03%]
拟议的sit1基因在Mucor lusitanicus孢子正常萌发和致病性中的作用
Bernadett Vágó,Kitti Bauer,Naomi Varghese et al.
Bernadett Vágó et al.
Mucormycosis is a life-threatening infection caused by certain members of the fungal order Mucorales, with increased incidence in recent years. Individuals with untreated diabetes mellitus, and patients treated with deferoxamine are particu...