Occurrence and potential mechanism of holin-mediated non-lytic protein translocation in bacteria [0.03%]
细菌中holin介导的非溶菌蛋白转运现象及其潜在机制
Thomas Brüser,Denise Mehner-Breitfeld
Thomas Brüser
Holins are generally believed to generate large membrane lesions that permit the passage of endolysins across the cytoplasmic membrane of prokaryotes, ultimately resulting in cell wall degradation and cell lysis. However, there are more and...
Haiheng Xu,Yiqiao Hu,Jinhui Wu
Haiheng Xu
Cancer immunotherapy, which use the own immune system to attack tumors, are increasingly popular treatments. But, due to the tumor immunosuppressive microenvironment, the antigen presentation in the tumor is limited. Recently, a growing num...
The rise of Candida auris: from unique traits to co-infection potential [0.03%]
耳念珠菌的崛起：从独特的特征到潜在的合并感染能力
Nadine B Egger,Katharina Kainz,Adina Schulze et al.
Nadine B Egger et al.
Candida auris is a multidrug resistant (MDR) fungal pathogen with a crude mortality rate of 30-60%. First identified in 2009, C. auris has been rapidly emerging to become a global risk in clinical settings and was declared an urgent health ...
Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles [0.03%]
Osh6的上调可增强向液泡传递的抗衰老通路
Ilham Kadhim,Nazneen Begum,William King et al.
Ilham Kadhim et al.
Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxyste...
Swimming faster despite obstacles: a universal mechanism behind bacterial speed enhancement in complex fluids [0.03%]
克服困难更快游泳：复杂流体中细菌速度提升的普适机制
Shashank Kamdar,Xiang Cheng
Shashank Kamdar
Bacteria constitute about 15% of global biomass and their natural environments often contain polymers and colloids, which show complex flow behaviors. It is crucial to study their motion in such environments to understand their growth and s...
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens [0.03%]
窄谱抗生素靶向细菌病原体的设计路线图
Xinyun Cao,Robert Landick,Elizabeth A Campbell
Xinyun Cao
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems. Broad-spectrum antibiotics eradicate the normal gut microbiome, killing protective...
Investigating the role of G-quadruplexes at Saccharomyces cerevisiae telomeres [0.03%]
酵母端粒G-四链体的作用研究
Sonia Stinus,Fernando R Rosas Bringas,Lisa Wanders et al.
Sonia Stinus et al.
The G-quadruplex consensus motif G≥3NxG≥3NxG≥3NxG≥3 is found at telomeres of many species, ranging from yeast to plants to humans, but the biological significance of this fact remains largely unknown. In this study, we examine the in vi...
Breaking the clip for cargo unloading from motor proteins: mechanism and significance [0.03%]
电机蛋白货运卸载的“破剪”机制及其意义
Keisuke Obara,Takumi Kamura
Keisuke Obara
The mitochondrion is an essential organelle involved in ATP generation, lipid metabolism, regulation of calcium ions, etc. Therefore, it should be inherited properly by newly generated cells. In the budding yeast Saccharomyces cerevisiae, m...
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword [0.03%]
结核分枝杆菌的脂肪酸代谢：双刃剑效应
Camila G Quinonez,Jae Jin Lee,Juhyeon Lim et al.
Camila G Quinonez et al.
Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host's fatty acids as a main carbo...
Air- and dustborne fungi in repositories of the National Archive of the Republic of Cuba [0.03%]
古巴国家档案馆中的空气和灰尘真菌
Sofia Borrego,Isbel Vivar,Alian Molina
Sofia Borrego
This study has as objectives to determine the concentration and diversity of the air- and dustborne mycobiota in seven National Archive of the Republic of Cuba repositories, and to assess the potential risk of biodeterioration that isolated...