Centromere Protein I, a Cell Cycle Checkpoint Gene, Accelerates Tumor Progression via the Hippo Pathway and Mediates Immune Escape in Hepatocellular Carcinoma [0.03%]
中心体蛋白I通过Hippo信号通路促进肝癌进展并介导免疫逃逸
Risheng He,Yi Xu,Pengbo Zhang et al.
Risheng He et al.
Background and aims: Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma (HCC). However, their precise roles and underlying mechanisms remain insuffic...
Human Albumin-enriched Peritoneal Dialysis: A Novel Approach to Manage Refractory Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease [0.03%]
人血白蛋白富集腹膜透析：治疗失代偿期慢性肝病难治性腹水和肾功能障碍的新方法
Mario Romeo,Silvio Borrelli,Marcello Dallio et al.
Mario Romeo et al.
For individuals with decompensated advanced chronic liver disease (dACLD), the onset of refractory ascites (RA) represents a dramatic event. In this setting, a relevant proportion of RA patients develop kidney dysfunction, as well as hepato...
Fecal Microbiome and Bile Acid Profiles Differ in Preterm Infants with Parenteral Nutrition-associated Cholestasis [0.03%]
早产儿肠外营养相关性胆汁淤积患儿粪便菌群及 bile acid谱特征不同
Ellen S Wagner,Kaitlyn Oliphant,Mark D&#x;Souza et al.
Ellen S Wagner et al.
Background and aims: Parenteral nutrition (PN)-associated cholestasis (PNAC) is frequently diagnosed in premature infants; however, not all PN-exposed infants develop PNAC. We propose that, in premature infants receiving ...
Screening for Mutations Causing ACOX2 Deficiency-associated Hypertransaminasemia in Patients with Cryptogenic Liver Injury [0.03%]
ACOX2缺陷相关性转氨酶升高的致病突变在原因不明肝损伤患者中的筛查研究
Elisa Herraez,Maria J Monte,Marta Alonso-Peña et al.
Elisa Herraez et al.
IL1RA+ Myeloid-derived Suppressor Cells Activate Epithelial-mesenchymal Transition to Facilitate Lymphatic and Hepatic Metastasis in Pancreatic Ductal Carcinoma [0.03%]
胰导管腺癌中髓系来源抑制细胞活化上皮间质转化促进淋巴结和肝转移(IL1RA+)
Huan Liu,Jian Zhang,Shengnan Lv et al.
Huan Liu et al.
Background and aims: Hepatic metastasis (HM) and lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC) are associated with worse overall survival, largely due to the immunosuppressive microenvironment. However,...
Research Progress on Leptin in Metabolic Dysfunction-associated Fatty Liver Disease [0.03%]
代谢失调相关性脂肪肝病的瘦素研究进展
Jian-Li Wang,Yue Xiao,Ming-Long Li et al.
Jian-Li Wang et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a significant challenge in modern medicine due to its high prevalence. The pathogenesis of MAFLD involves a complex dysmetabolic process consistent with the "multiple-hit" h...
Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications [0.03%]
肝硬化心肌病的炎症和线粒体功能障碍：治疗意义
Yijie Ding,Chengfeng Huang,Guannan Yang et al.
Yijie Ding et al.
Background and aims: Cirrhotic cardiomyopathy (CCM) is a significant complication of cirrhosis, but its progression and underlying mechanisms remain incompletely understood. This study aimed to investigate dynamic changes...
The Mechanisms behind Thrombocytopenia in Patients with Portal Hypertension and Chronic Liver Disease [0.03%]
门脉高压和慢性肝病患者血小板减少的机制
Valeria M Fernández-Garibay,Mariana M Ramírez-Mejia,Guadalupe Ponciano-Rodriguez et al.
Valeria M Fernández-Garibay et al.
Persistent liver injury halts the regenerative capacity of hepatocytes and activates mechanisms that result in the replacement of normal hepatic parenchyma with extracellular matrix deposits. As liver fibrosis develops, the liver undergoes ...
Consensus on the Management of Liver Injury Associated with Targeted Drugs and Immune Checkpoint Inhibitors for Hepatocellular Carcinoma (Version 2024) [0.03%]
靶向药物和免疫检查点抑制剂相关肝细胞癌肝损伤管理共识（2024版）
Suxian Zhao,Jie Li,Lingdi Liu et al.
Suxian Zhao et al.
With the widespread application of systemic treatments for hepatocellular carcinoma, liver injury caused by molecular targeted drugs and immune checkpoint inhibitors has become a common clinical problem. The Chinese Society of Hepatology, C...
DysUFMylation of SREBP1 Promotes the Progression of Hepatocellular Carcinoma by Reprogramming Lipid Metabolism [0.03%]
SREBP1 去泛素化促进肝细胞癌的发生发展并重塑脂质代谢
Xukang Gao,Zeping Han,Min Xu et al.
Xukang Gao et al.
Background and aims: Sterol regulatory element-binding protein 1 (SREBP1), a key regulator of lipogenesis, is highly expressed in tumors, but the mechanisms sustaining its elevated levels remain unclear. The role of UFMyl...