Metabolic Risk Factors and Clinical Presentations of Metabolic Dysfunction-associated Steatotic Liver Disease Using Data from the All of Us Research Program [0.03%]
利用All Of Us研究项目的代谢性肝病的代谢危险因素和临床表现特征的研究
Ke-Qin Hu,Seyedeh Neelufar Payrovnaziri,Argyrios Ziogas et al.
Ke-Qin Hu et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. The present study aimed to utilize the All of Us electronic health record-linked ...
Repurposing SGLT2 Inhibitors for Cirrhotic Ascites: From Mechanistic Research to Clinical Exploration [0.03%]
从机制研究到临床探索：SGLT2抑制剂用于肝硬化腹水的新用途
Yuan Gao,Yunyi Gao,Dong Ji et al.
Yuan Gao et al.
Cirrhotic ascites develops when portal hypertension and arterial under-filling chronically activate neuro-hormonal pathways that drive renal sodium-water retention. Augmented proximal tubular sodium reabsorption, predominantly mediated by t...
Traditional and Novel Virologic Markers for Functional Cure and HBeAg Loss with Pegylated Interferon in Chronic Hepatitis B: A Systematic Review and Meta-analysis [0.03%]
慢性乙型肝炎患者接受聚乙二醇干扰素治疗后实现功能性治愈和HBeAg血清学转换的新型与传统病毒学生物标志物系统评价和meta分析
Ying Zhang,Long-Fei Wang,Jing Chen et al.
Ying Zhang et al.
Background and aims: The rate of functional cure (HBsAg loss) remains unsatisfactory following pegylated interferon (PEG-IFN) treatment in chronic hepatitis B. To optimize PEG-IFN administration, this study aimed to evalu...
Serum miR-381-3p: Diagnostic Role and Mechanisms in Liver Transplant Ischemia-reperfusion Injury [0.03%]
血清miR-381-3p在肝移植缺血再灌注损伤中的诊断价值及机制研究
Xiaobin Chi,Zerun Lin,Zhijian Chen et al.
Xiaobin Chi et al.
Background and aims: Hepatic ischemia-reperfusion (HIR) injury impairs outcomes post-liver transplantation. Therefore, we aimed to investigate the role and mechanism of miR-381-3p in HIR. ...
Prognostic Nutritional Index Predicts Outcomes in Hepatocellular Carcinoma Treated with Atezolizumab and Bevacizumab: A Propensity Score-matched Analysis [0.03%]
预后营养指数可预测阿特朱单抗联合贝伐珠单抗治疗肝细胞癌患者疗效：倾向性评分匹配分析
Yuan-Hung Kuo,Wei Teng,Yen-Hao Chen et al.
Yuan-Hung Kuo et al.
Background and aims: The prognostic nutritional index (PNI), calculated from serum albumin and lymphocyte count, reflects a patient's immune-nutritional status and has been proposed as a prognostic marker in hepatocellula...
Risk Factors and Biomarkers for Immune Checkpoint Inhibitor-mediated Hepatotoxicity: Emerging Insights and Future Perspectives [0.03%]
免疫检查点抑制剂介导肝毒性的危险因素和生物标志物：新见解与未来展望
Zaoqin Yu,Yanjiao Xu,Wei Li et al.
Zaoqin Yu et al.
In the past decade, immune checkpoint inhibitors (ICIs) have dramatically changed cancer treatment, significantly improving outcomes for patients with various malignancies. Nonetheless, their widespread application has resulted in a rise in...
Bidirectional Regulation between Metabolic Dysfunction-associated Steatotic Liver Disease and Sarcopenia via Liver-muscle Crosstalk [0.03%]
通过肝肌对话介导的代谢紊乱相关脂肪性肝病与肌少症之间的双向调控关系
Yeyu Song,Yameng Liu,Jie Jiang et al.
Yeyu Song et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia frequently coexist, yet their causal relationship and underlying mechanisms remain poorly defined. This study aimed to i...
Immune Checkpoint Inhibitor-induced Liver Injury: A Critical Appraisal of Treatment and Rechallenge Controversies [0.03%]
免疫检查点抑制剂诱导的肝损伤：治疗和再使用争议的关键评估
Fernando Bessone,Nelia Hernandez
Fernando Bessone
Cathepsin K Alleviates Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway and Inducing Hepatic Stellate Cell Apoptosis [0.03%]
猫粮蛋白酶K通过抑制TGF-β/Smads信号通路并诱导肝星状细胞凋亡来缓解肝纤维化
Zhandong Lin,Yue Shi,Mengjiao Sun et al.
Zhandong Lin et al.
Background and aims: Liver fibrosis is characterized by the excessive deposition of extracellular matrix, a process primarily driven by activated hepatic stellate cells (HSCs), and currently lacks effective therapy. Cathe...
Tumor Vaccines in Hepatocellular Carcinoma: Advances, Challenges, and the Path Toward Precision Immunotherapy [0.03%]
肝细胞癌的肿瘤疫苗：进展、挑战及精准免疫治疗之路
Bin Niu,Jun Xu,Liaoyun Zhang
Bin Niu
Primary hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with curative options still limited for patients with advanced disease. As an emerging modality of cancer immunotherapy, tumor v...