m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease [0.03%]
YTHDF1介导的NUPR1 mRNA m1A甲基化修饰促进非酒精性脂肪肝病进展
Nan Luo,Zhihai Xu,Dongmei Zhao et al.
Nan Luo et al.
Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder with a complex pathogenesis. Although epitranscriptomic modifications such as N6-methyladenosine (m6A) have been implicated i...
Tongue Image Analysis and Clinical Data Fusion: A Novel Approach for Non-invasive Diagnosis of Metabolic Dysfunction-associated Fatty Liver Disease [0.03%]
舌象与临床数据融合用于代谢紊乱相关脂肪肝的无创诊断研究
Chen-Xia Lu,Chuan-Xi Tian,Yi-Bo Jiao et al.
Chen-Xia Lu et al.
Background and aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a predominant cause of chronic liver disease, underscoring the demand for accessible, non-invasive diagnostic tools. Tongue diag...
Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma [0.03%]
神经氨酸(Neu5Gc)-依赖的血清免疫球蛋白G糖基化作用作为肝细胞癌诊断标志物的研究
Xu Cao,Xiwei Lu,Qingwei Li et al.
Xu Cao et al.
Background and aims: Given the lack of efficient biomarkers for hepatocellular carcinoma (HCC) diagnosis, this study aimed to develop an HCC diagnostic strategy based on serum protein glycosylation signatures. We characte...
Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B: A Prospective Trial [0.03%]
聚乙二醇干扰素治疗免疫耐受慢性乙肝患者可提高应答率：一项前瞻性研究
Min Liu,Lili Zuo,Yuting Zhang et al.
Min Liu et al.
Background and aims: The optimal management strategy for adults with immune-tolerant (IT) chronic hepatitis B infection remains undefined. This study aimed to investigate the efficacy and predictive factors of a pegylated...
Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization [0.03%]
半胱天冬酶-1/凋亡相关滴蛋白家族成员1/白细胞介素1转化酶3轴在移植肝炎中的作用及干预策略研究
Xianwu Yang,Shirui Huang,Ruisi Ma et al.
Xianwu Yang et al.
Background and aims: Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely understood. This study aimed to investigate the role of galectin-3 ...
Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025) [0.03%]
代谢紊乱相关脂肪性肝病基层诊疗指南（2025年）
Wenjing Ni,Junping Shi,Jian-Gao Fan et al.
Wenjing Ni et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the leading causes of chronic liver diseases in China, imposing a substantial and growing burden on the healthcare system. Considering the large number of indivi...
Analysis of Protein Binding to Liver Mitochondria by Horizontal Polyacrylamide Gel Electrophoresis Using a Converted Agarose Electrophoresis Unit [0.03%]
改造成琼脂糖电泳装置的水平聚丙烯酰胺凝胶电泳分析肝线粒体蛋白质结合能力的研究
Bianca Thakkar,George Y Wu
Bianca Thakkar
Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure [0.03%]
单细胞测序揭示了与乙型肝炎病毒相关急性-on-慢性肝功能衰竭的内皮细胞损伤和免疫性血栓形成相关的中性粒细胞胞外陷阱
Xitang Li,Suping Hai,Xizhe Zheng et al.
Xitang Li et al.
Background and aims: Immunothrombosis, the interplay between immune activation and coagulation, contributes to disease progression in inflammatory disorders. Its role in hepatitis B virus-related acute-on-chronic liver fa...
George Y Wu
George Y Wu
Congenital portosystemic shunts (CPSS) are rare vascular anomalies characterized by abnormal communication between the portal and systemic venous systems, resulting in partial or complete diversion of portal blood away from the liver. These...
Unlocking the Future of Hepatocellular Carcinoma Early Diagnosis: The Promise of Extracellular Vesicle Biomarkers [0.03%]
解启未来肝细胞癌早期诊断的新纪元——外泌体生物标志物的希望
Kunxiang Li,Zhihua Zuo,Xinyi Ou et al.
Kunxiang Li et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignant tumors globally, with a notably low five-year survival rate. Its high mortality is largely attributed to challenges in early detection. Extracellular vesic...