ATP-binding Cassette Transporter Defects and Their Roles in Hepatic Diseases [0.03%]
ATP结合盒转运蛋白缺陷及其在肝病中的作用
Danzhu Zhao,George Y Wu
Danzhu Zhao
ATP-binding cassette (ABC) transporters are transmembrane proteins involved in the translocation of bilirubin, bile acids, phospholipids, and cholesterol into bile canaliculi. Mutations in particular genes encoding these transporters-includ...
Expert Consensus on the Diagnosis and Management of Inherited Hyperbilirubinemia (2025) [0.03%]
遗传性高胆红素血症诊疗专家共识(2025年版)
Sujun Zheng,Xiaoyuan Xu,Yuemin Nan et al.
Sujun Zheng et al.
To support clinicians in making informed decisions regarding the diagnosis and management of inherited hyperbilirubinemia, including Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson syndrome, and Rotor syndrome, the Inherited and Me...
Applications of Artificial Intelligence and Smart Devices in Metabolic Dysfunction-associated Steatotic Liver Disease [0.03%]
人工智能和智能设备在代谢紊乱相关肝脂肪变性疾病中的应用
Wenfeng Zhu,Qi Zheng,Xinyi Xu et al.
Wenfeng Zhu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now considered to be among the most prevalent chronic liver diseases worldwide. Its comprehensive management encompasses multiple stages, including risk assessment, early d...
Quality and Quantity? The Clinical Significance of Myosteatosis in Various Liver Diseases: A Narrative Review [0.03%]
质量与数量？肝病肌肝脂肪浸润的临床意义：综述文章
Jie Yang,Qing Liu,Chao Sun
Jie Yang
Myosteatosis is associated with poor outcomes in various liver diseases. However, standardized methods for assessing, defining, and diagnosing myosteatosis in the context of liver diseases remain unclear. Furthermore, the underlying mechani...
Expert Consensus on Clinical Applications of Fecal Microbiota Transplantation for Chronic Liver Disease (2025 edition) [0.03%]
慢性肝病粪菌移植临床应用专家共识（2025版）
Yongjian Zhou,Li Yang,Yuemin Nan;Liver Related Digestive Diseases Group et al.
Yongjian Zhou et al.
The gut microbiota is crucial in maintaining host health and liver function. Fecal microbiota transplantation (FMT) has shown promising potential in treating chronic liver diseases. To help clinicians quickly master and standardize the clin...
Current and Emerging Issues in Familial Hypobetalipoproteinemia-related Steatotic Liver Diseases [0.03%]
遗传性低β-脂蛋白血症相关肝脂肪变性疾病当前和新兴的问题
Tian-Wen Lou,Tian-Yi Ren,Jian-Gao Fan
Tian-Wen Lou
Familial hypobetalipoproteinemia (FHBL), caused by apolipoprotein B (APOB) variants, disrupts APOB-containing lipoprotein synthesis, leading to reduced serum total cholesterol, low-density lipoprotein cholesterol, and APOB. Heterozygous car...
Nutrient-stimulated Hormone-based Therapies: A New Frontier in the Prevention and Management of MASH-associated Hepatocellular Carcinoma [0.03%]
以营养刺激激素为基础的疗法：预防和管理MASH相关肝细胞癌的新前沿阵地
Richard Phillips,Yuk Ting Ma,Wasim Hanif et al.
Richard Phillips et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease in the Western world, driven by obesity, insulin resistance, and systemic inflammation. Its progressive form, metabolic dysfunctio...
Longitudinal Profile of HBsAg Isoforms and Circulating Immune Complexes in the Natural History of Chronic Hepatitis B Infection [0.03%]
慢性乙型肝炎感染自然史中HBsAg亚型和循环免疫复合物的纵向特征
Lung-Yi Mak,Mark Anderson,Tiffany Fortney et al.
Lung-Yi Mak et al.
PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages [0.03%]
PDK4通过磷酸化STAT1介导M1型巨噬细胞极化调节急性-on-慢性肝衰竭炎症损伤
Shilong Dong,Luyuan Ma,Chuan Shen et al.
Shilong Dong et al.
Background and aims: Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome characterized by systemic inflammation and immune dysregulation, in which macrophages play a key role in organ injury. This study a...
Protein Induced by Vitamin K Absence or Antagonist II in Primary Liver Cancer: Basic Research Insights and Clinical Applications [0.03%]
维生素K缺乏或拮抗诱导蛋白Ⅱ在原发性肝癌中的基础研究进展及临床应用前景
Xin Zhang,Rong Wang,Bin Niu et al.
Xin Zhang et al.
Hepatocellular carcinoma (HCC) is the most common subtype of primary liver cancer and continues to be a major cause of cancer-related mortality, particularly in regions of China with a high hepatitis B virus prevalence. Early-stage diagnosi...