Eight-year Results from Two Randomized Phase 3 Trials of Tenofovir Alafenamide for Chronic Hepatitis B Virus Infection in China [0.03%]
中国慢性乙肝患者接受替诺福韦阿拉芬酰胺治疗的8年期随机III期临床试验结果
Jinlin Hou,Qin Ning,Zhongping Duan et al.
Jinlin Hou et al.
Background and aims: Tenofovir alafenamide (TAF) has demonstrated comparable efficacy to tenofovir disoproxil fumarate (TDF), with improved renal and bone safety, in Chinese participants with chronic hepatitis B enrolled ...
Hepatosplenic Volumes and Portal Pressure Gradient Identify One-year Further Decompensation Risk Post-transjugular Intrahepatic Portosystemic Shunt [0.03%]
经颈静脉肝内门体分流术后一年进一步失代偿风险的肝脏、脾脏容积和门脉压力梯度评估指标
Xinyu Chen,Yicheng Lin,Kefeng Jia et al.
Xinyu Chen et al.
Background and aims: Further decompensation in cirrhosis is associated with increased mortality. However, reliable tools to predict further decompensation after transjugular intrahepatic portosystemic shunt (TIPS) are cur...
Primary Biliary Cholangitis-associated Osteoporosis: Contemporary Review of Pathogenesis and Management [0.03%]
原发性胆汁性胆管炎相关性骨质疏松症：发病机制及治疗进展的当代综述
Jiaqi Yang,Shuhao Su,Ting Yuan et al.
Jiaqi Yang et al.
Primary biliary cholangitis (PBC) is a chronic cholestatic disorder in which symptoms exert a direct influence on patients' quality of life. Beyond pruritus and fatigue, patients with PBC are also prone to developing osteoporosis (OP). This...
Genotype-specific Response to 144-week Entecavir Therapy for HBeAg-positive Chronic Hepatitis B with a Particular Focus on Histological Improvement: A Prospective Study [0.03%]
乙型肝炎e抗原阳性慢性乙肝患者长期恩替卡韦治疗的基因分型特异性反应：以改善病理组织学为重点的一项前瞻性研究
Lexin Liu,Qiumiao Xu,Shanshan Lin et al.
Lexin Liu et al.
Background and aims: Chronic hepatitis B (CHB) poses a major global health burden, with China particularly affected. Effective antiviral therapy is crucial to prevent disease progression, but responses may vary by Hepatit...
Extrahepatic Autoimmune Diseases in Autoimmune Hepatitis: Their Prevalence, Predictors, and Influence on Early Treatment Outcomes [0.03%]
自身免疫性肝炎相关性肝外自身免疫性疾病及其影响因素和对早期治疗的影响
Yue-Yang Ma,Wei-Hao Zhao,Ke-Ying Ou et al.
Yue-Yang Ma et al.
Background and aims: Autoimmune hepatitis (AIH) frequently coexists with extrahepatic autoimmune diseases (EADs), but their prevalence, characteristics, progression, and treatment effect in the Han Chinese population rema...
Serum Interleukin-8 for Differentiating Invasive Pulmonary Aspergillosis from Bacterial Pneumonia in Patients with HBV-Associated Acute-on-Chronic Liver Failure [0.03%]
血清中性粒细胞弹性蛋白酶-interleukin-8复合物鉴别HBV相关急性肝功能衰竭并发细菌性肺炎和侵袭性肺曲霉病的价值研究
Lanyue Huang,Yuzhao Feng,Wei Wang et al.
Lanyue Huang et al.
Background and aims: Infections are frequent and lethal complications of acute-on-chronic liver failure (ACLF). Reliable biomarkers to distinguish fungal from bacterial infections remain limited. Given the central role of...
Chinese Guidelines for Clinical Diagnosis, Treatment, and Management of Cirrhosis (2025) [0.03%]
中国肝硬化诊疗和管理指南（2025）
Xiaoyuan Xu,Huiguo Ding,Hong You et al.
Xiaoyuan Xu et al.
The Chinese Society of Hepatology of the Chinese Medical Association has invited experts in relevant fields to revise and rename the 2019 "Chinese Guidelines on the Management of Liver Cirrhosis" to "Chinese Guidelines for Clinical Diagnosi...
Oxytocin Attenuates Metabolic Dysfunction-associated Steatotic Liver Disease via AMPK/SREBP1c/FAS-mediated Suppression of Hepatic Lipogenesis [0.03%]
oxytocin通过AMPK/SREBP1c/FAS介导的抑制肝脂质合成来减轻与代谢功能障碍相关的肝脂肪变性疾病
Yue Xu,Siqian Lu,Hongpei Wu et al.
Yue Xu et al.
Background and aims: As the leading cause of chronic liver disease globally, metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective therapies. This study aimed to investigate the therapeutic pote...
TF-rs1049296 C>T Variant Modifies the Association between Hepatic Iron Stores and Liver Fibrosis in Metabolic Dysfunction-associated Steatotic Liver Disease [0.03%]
代谢功能异常相关肝脂肪变性肝病中铁储存与肝纤维化关联的遗传易感位点研究：TF-rs1049296 C>T变异体的影响
Sui-Dan Chen,Ka-Te Huang,Huai Zhang et al.
Sui-Dan Chen et al.
Background and aims: Hepatic iron deposition (HID) in the reticuloendothelial system (RES) is associated with histological severity in metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to ...
Hepatitis C Patient Education: Large Language Models Show Promise in Disseminating Guidelines [0.03%]
丙型肝炎患者教育：大型语言模型有望传播指南方针以取得成效
Jinyan Chen,Ruijie Zhao,Chiyu He et al.
Jinyan Chen et al.