Ramesh Kumar,Sabbu Surya Prakash,Rajeev Nayan Priyadarshi et al.
Ramesh Kumar et al.
Sarcopenia, a condition of low muscle mass, quality, and strength, is commonly found in patients with chronic liver disease (CLD) and is associated with adverse clinical outcomes including reduction in quality of life, increased mortality, ...
Role of Small Extracellular Vesicles in Liver Diseases: Pathogenesis, Diagnosis, and Treatment [0.03%]
小型胞外囊泡在肝脏疾病中的作用：病理机制、诊断与治疗
Tingmao Xue,Judy Wai Ping Yam
Tingmao Xue
Extracellular vesicles (EVs) are vesicular bodies that bud off from the cell membrane or are secreted virtually by all cell types. Small EVs (sEVs or exosomes) are key mediators of cell-cell communication by delivering their cargo, includin...
FOXO1 Alleviates Liver Ischemia-reperfusion Injury by Regulating the Th17/Treg Ratio through the AKT/Stat3/FOXO1 Pathway [0.03%]
FOXO1通过AKT/Stat3/FOXO1通路调节Th17/Treg比值来缓解肝脏缺血再灌注损伤
Hao-Zhen Ren,Sen-Zhe Xia,Xue-Qian Qin et al.
Hao-Zhen Ren et al.
Background and aims: Hepatic ischemic reperfusion injury (IRI) occurring during surgery seriously affects patient prognosis. The specific mechanism of IRI has not been fully elucidated. The study aim was to explore the ch...
Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review [0.03%]
钙调磷酸酶抑制剂在成人自身免疫性肝炎治疗中的应用：系统评价
Martine Amc Baven-Pronk,Joffre M Hew Jr,Maaike Biewenga et al.
Martine Amc Baven-Pronk et al.
Background and aims: A considerable number of autoimmune hepatitis (AIH) patients completely or partially fail on first-line treatment. Several studies on the use of calcineurin inhibitors (CNIs) in the treatment of AIH h...
Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice [0.03%]
气体蛋白D抑制剂磺胺 Necrosulfonamide 缓解脂多糖/D-半乳糖胺诱导的小鼠急性肝功能衰竭
Yi-Long Wu,Wei-Jie Ou,Ming Zhong et al.
Yi-Long Wu et al.
Background and aims: Acute liver failure (ALF) is associated with high mortality. Gasdermin D (GSDMD) is the executioner of pyroptosis and is involved in the pathophysiology of immune dysregulation This study investigated...
Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature [0.03%]
免疫治疗后的肉瘤样肝内胆管癌一例报告及文献复习
Zheng Zeng,Yu Liu,Jing Yu et al.
Zheng Zeng et al.
Sarcomatoid carcinoma is a rare tumor that is composed of a mixture of malignant epithelial cells and mesenchymal cells. Many studies have reported that sarcomatoid carcinoma occurs in multiple organs including the liver. Sarcomatoid intrah...
Teresa Da Cunha,George Y Wu,Haleh Vaziri
Teresa Da Cunha
Immune checkpoint inhibitors (ICIs) suppress the function of immune checkpoints, which are involved in downregulating immune responses. These lead to an increased activation of the function of T cells, increased release of cytokines, and de...
Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update [0.03%]
IL-1家族成员在肝脏疾病治疗中的新进展
Ines Bilić Ćurčić,Tomislav Kizivat,Ana Petrović et al.
Ines Bilić Ćurčić et al.
Interleukin (IL) 1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the liver. Progression of acute and chronic liver diseases regardless of etiology depends on the stage of ...
Quzhi Formula Alleviates Nonalcoholic Steatohepatitis by Impairing Hepatocyte Lipid Accumulation and Inflammation via Bip/eIF2α Signaling [0.03%]
曲芝方通过Bip/eIF2α信号通路减轻肝细胞脂质蓄积和炎症从而缓解非酒精性脂肪性肝炎
Yue-Lan Wu,Jiao-Xiang Wu,Ting-Ting Shen et al.
Yue-Lan Wu et al.
Background and aims: The Quzhi formula, a Chinese medicine compound prescription, relieves nonalcoholic steatohepatitis (NASH) symptoms. This study aimed to explore the mechanism of the Quzhi formula against NASH. ...
A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia [0.03%]
非酒精性脂肪肝病中血脂调节的班级效应网络荟萃分析在异常血脂中的应用
Jieling Xiao,Cheng-Han Ng,Yip-Han Chin et al.
Jieling Xiao et al.
Background and aims: Pharmaceutical therapy for NASH is associated with lipid modulation, but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness. A network meta-analysis was conduct...