Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma [0.03%]
神经氨酸(Neu5Gc)-依赖的血清免疫球蛋白G糖基化作用作为肝细胞癌诊断标志物的研究
Xu Cao,Xiwei Lu,Qingwei Li et al.
Xu Cao et al.
Background and aims: Given the lack of efficient biomarkers for hepatocellular carcinoma (HCC) diagnosis, this study aimed to develop an HCC diagnostic strategy based on serum protein glycosylation signatures. We characte...
Pegylated Interferon-based Treatment Improves Response Rates in Immune-tolerant Patients with Chronic Hepatitis B: A Prospective Trial [0.03%]
聚乙二醇干扰素治疗免疫耐受慢性乙肝患者可提高应答率：一项前瞻性研究
Min Liu,Lili Zuo,Yuting Zhang et al.
Min Liu et al.
Background and aims: The optimal management strategy for adults with immune-tolerant (IT) chronic hepatitis B infection remains undefined. This study aimed to investigate the efficacy and predictive factors of a pegylated...
Galectin-3 Promotes Graft Injury via NLRP3 Pyroptosis in Steatotic Liver Transplantation: A Therapeutic Target for Donor Optimization [0.03%]
半胱天冬酶-1/凋亡相关滴蛋白家族成员1/白细胞介素1转化酶3轴在移植肝炎中的作用及干预策略研究
Xianwu Yang,Shirui Huang,Ruisi Ma et al.
Xianwu Yang et al.
Background and aims: Steatotic donor livers are highly susceptible to post-transplant dysfunction; however, the underlying mechanisms remain incompletely understood. This study aimed to investigate the role of galectin-3 ...
Guidelines for Diagnosis and Management of Metabolic Dysfunction-associated Fatty Liver Disease in Primary Care (2025) [0.03%]
代谢紊乱相关脂肪性肝病基层诊疗指南（2025年）
Wenjing Ni,Junping Shi,Jian-Gao Fan et al.
Wenjing Ni et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the leading causes of chronic liver diseases in China, imposing a substantial and growing burden on the healthcare system. Considering the large number of indivi...
Analysis of Protein Binding to Liver Mitochondria by Horizontal Polyacrylamide Gel Electrophoresis Using a Converted Agarose Electrophoresis Unit [0.03%]
改造成琼脂糖电泳装置的水平聚丙烯酰胺凝胶电泳分析肝线粒体蛋白质结合能力的研究
Bianca Thakkar,George Y Wu
Bianca Thakkar
Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure [0.03%]
单细胞测序揭示了与乙型肝炎病毒相关急性-on-慢性肝功能衰竭的内皮细胞损伤和免疫性血栓形成相关的中性粒细胞胞外陷阱
Xitang Li,Suping Hai,Xizhe Zheng et al.
Xitang Li et al.
Background and aims: Immunothrombosis, the interplay between immune activation and coagulation, contributes to disease progression in inflammatory disorders. Its role in hepatitis B virus-related acute-on-chronic liver fa...
George Y Wu
George Y Wu
Congenital portosystemic shunts (CPSS) are rare vascular anomalies characterized by abnormal communication between the portal and systemic venous systems, resulting in partial or complete diversion of portal blood away from the liver. These...
Unlocking the Future of Hepatocellular Carcinoma Early Diagnosis: The Promise of Extracellular Vesicle Biomarkers [0.03%]
解启未来肝细胞癌早期诊断的新纪元——外泌体生物标志物的希望
Kunxiang Li,Zhihua Zuo,Xinyi Ou et al.
Kunxiang Li et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignant tumors globally, with a notably low five-year survival rate. Its high mortality is largely attributed to challenges in early detection. Extracellular vesic...
A Multi-omics Investigation Identifies TACC3 as a Driver of Immunosuppression in Intrahepatic Cholangiocarcinoma via Activation of the STAT3-PD-L1 Axis [0.03%]
多组学研究识别TACC3通过激活STAT3-PD-L1轴在肝内胆管癌中发挥免疫抑制作用
Hao Wang,Zhiquan Xu,Ziqi Zhang et al.
Hao Wang et al.
Background and aims: The immunosuppressive tumor microenvironment (TME) limits immunotherapy efficacy in intrahepatic cholangiocarcinoma (ICC). Understanding the molecular drivers of this TME is essential for developing n...
Hypertension Associated with the Risk of Extrahepatic Cancers in the Metabolic Dysfunction-associated Steatotic Liver Disease Population: A Multicenter Cross-sectional Study in China [0.03%]
与代谢功能障碍相关肝脂肪变性肝病人群的高血压与全身恶性肿瘤发病风险的相关性：中国多中心横断面研究
Xinyue Zhao,Feng Xue,Shanshan Wang et al.
Xinyue Zhao et al.
Background and aims: Extrahepatic cancers have been recognized as a significant outcome of metabolic dysfunction-associated steatotic liver disease (MASLD), which involves five cardiometabolic risk factors, including hype...