The Association of Alpha-1 Antitrypsin Deficiency and Arterial Aneurysms: An Update and Review [0.03%]
α-1抗胰蛋白酶缺乏与动脉瘤相关的联系：最新研究及综述
Moana Da Silva Santiago,George Y Wu
Moana Da Silva Santiago
Alpha-1 antitrypsin deficiency (AATD) is an autosomal codominant genetic disorder caused by mutations in the SERPINA1 gene. It results in reduced circulating levels of alpha-1 antitrypsin (AAT), a serine proteinase inhibitor (PI) primarily ...
Consensus versus Outcome-based Definitions of Acute-on-chronic Liver Failure: Implications for Risk Stratification and Case Identification [0.03%]
急性肝衰竭与慢性肝病 definitions和基于结果的定义：风险分层和病例识别的含义
Nipun Verma,Tingting Qi,Pratibha Garg et al.
Nipun Verma et al.
Background and aims: Acute-on-chronic liver failure (ACLF) lacks a universally accepted definition, and recent efforts have proposed consensus organ failure criteria. In this study, we aimed to compare the clinical validi...
Occlusion of Paraspinal Vein Shunt Alleviated Post-TIPS Hepatic Myelopathy in a Patient with Cirrhosis [0.03%]
肝硬化患者经颈静脉肝内门体分流术(TIPS)后侧脊椎静脉闭塞缓解了肝性肌病
Yuhong Suo,Lixue Xu,Xinyan Zhao et al.
Yuhong Suo et al.
Hepatic myelopathy, a rare neurological complication of decompensated chronic liver disease, profoundly impairs quality of life. While liver transplantation represents the only curative treatment for hepatic myelopathy, we report a case in ...
Bile Drainage Improves Survival in Amatoxin-induced Severe Liver Injury: A Prospective Pilot Cohort Study [0.03%]
胆汁引流可改善氨基糖苷诱导的重度肝损伤生存率：一项前瞻性队列研究
Xiuying Ma,Bin Han,Wei Yue et al.
Xiuying Ma et al.
Background and aims: Amatoxin-containing mushroom poisoning causes fatal acute liver failure with >50% mortality despite maximal medical therapy. Interrupting the enterohepatic recirculation of amatoxins is a mechanistica...
Metabolic Dysfunction-associated Steatotic Liver Disease Diminishes the Efficacy of miR-125b-5p-engineered MSC Therapy for Hepatocellular Carcinoma via HK2 Upregulation: A Multimodal Theranostic Study [0.03%]
代谢功能紊乱相关脂肪性肝病通过HK2上调降低miR-125b-5p工程间充质干细胞治疗肝细胞癌的疗效：一种多模态诊疗研究
Lishan Shen,Xiaowen Luo,Xiaorui Su et al.
Lishan Shen et al.
Background and aims: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, underscoring the need for effective therapies. Although miR-125b-5p shows therapeutic potential, its efficacy in met...
A Novel Simplified Prognostic Model for 90-day Transplant-free Survival in Patients with Severe Acute Liver Injury/Acute Liver Failure [0.03%]
急性严重肝损伤/急性肝衰竭患者90天无移植生存的新型预后模型
Yan Ren,Manman Xu,Wenling Wang et al.
Yan Ren et al.
Background and aims: Early risk stratification of severe acute liver injury (SLI) that may progress to acute liver failure (ALF), is vital for timely intervention, but no universal prognostic assessment tool covers both c...
The Multifaceted Roles of Gut Microbiota and Their Metabolites in Metabolic Dysfunction-associated Steatotic Liver Disease: A Literature Review [0.03%]
肠道微生物及其代谢产物在代谢功能异常相关脂肪性肝病中的作用：文献综述
Yunqi Zhang,Dengqin Wang,Bo Zhuang et al.
Yunqi Zhang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major global health concern and encompasses a spectrum ranging from hepatic steatosis and metabolic dysfunction-associated steatohepatitis to liver fibrosis, cirr...
Mechanisms and Prognostic Assessment Value of Thyroid Hormone in Liver Failure [0.03%]
甲状腺激素的机制研究及其在肝衰竭中的预后评估价值
Hong Zhou,Hong Wu,Shao-Hui Su et al.
Hong Zhou et al.
Early and accurate prognostic assessment is crucial to avoid serious disease progression in patients with liver failure. Thyroid hormone is an important metabolic regulator involved in hepatic function. This review examines the pathophysiol...
m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease [0.03%]
YTHDF1介导的NUPR1 mRNA m1A甲基化修饰促进非酒精性脂肪肝病进展
Nan Luo,Zhihai Xu,Dongmei Zhao et al.
Nan Luo et al.
Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder with a complex pathogenesis. Although epitranscriptomic modifications such as N6-methyladenosine (m6A) have been implicated i...
Tongue Image Analysis and Clinical Data Fusion: A Novel Approach for Non-invasive Diagnosis of Metabolic Dysfunction-associated Fatty Liver Disease [0.03%]
舌象与临床数据融合用于代谢紊乱相关脂肪肝的无创诊断研究
Chen-Xia Lu,Chuan-Xi Tian,Yi-Bo Jiao et al.
Chen-Xia Lu et al.
Background and aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a predominant cause of chronic liver disease, underscoring the demand for accessible, non-invasive diagnostic tools. Tongue diag...