Regional Inequities in Metabolic Dysfunction-associated Steatotic Liver Disease Burden and Care Quality in High-burden Settings: Implications for Health Systems [0.03%]
高负担地区代谢功能障碍相关脂肪性肝病的区域不平等及其对卫生系统的启示
Kexin Zhang,Chengxia Kan,Sufang Sheng et al.
Kexin Zhang et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing rapidly, yet regional differences in burden and care quality remain unclear. This study aimed to compare regional inciden...
Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B [0.03%]
慢性乙型肝炎中短链脂肪酸和胆汁酸信号的作用
Siqi Sun,Sisi Yang,Yihe Yu et al.
Siqi Sun et al.
Chronic hepatitis B (CHB) remains a major global public health challenge. Current therapies based on nucleos(t)ide analogues and interferon mainly achieve long-term viral suppression, whereas only a small proportion of patients attain a fun...
A Dual Time Window-driven Strategy to Optimize Primary Biliary Cholangitis Treatment via Alkaline Phosphatase Normalization [0.03%]
基于双时间窗驱动的通过正常化碱性磷酸酶优化原发性胆汁性胆管炎治疗策略的研究
Han Zhao,Yansheng Liu,Yingmei Tang et al.
Han Zhao et al.
Background and aims: The current criterion of biochemical response to ursodeoxycholic acid in primary biliary cholangitis is an alkaline phosphatase (ALP) level of ≤1.67 × the upper limit of normal (ULN) after 12 months...
A Multi-omics and Machine Learning Framework Identifies Plasma SBDS as a Causal Biomarker and Therapeutic Target in Primary Sclerosing Cholangitis [0.03%]
多组学和机器学习框架识别出血清SBDS蛋白作为原发性硬化性胆管炎的因果生物标志物和治疗靶点
Pengfei Cheng,Yuanming Qiang,Yibo Sun et al.
Pengfei Cheng et al.
Background and aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease. Its molecular etiology remains poorly defined, hindering the development of mechanism-based diagnostics and therap...
Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review [0.03%]
降低肝性脑病复发风险：综述文章
Nikolaos T Pyrsopoulos,Nadege Gunn,Prasun K Jalal et al.
Nikolaos T Pyrsopoulos et al.
Hepatic encephalopathy (HE) is a neurologic complication of advanced liver disease (e.g., cirrhosis) resulting in impaired functioning and reduced quality of life. This condition is associated with a substantial burden for patients and thei...
Chronic Hepatitis B in the Asia-Pacific Region: Results of the 2023 Global Burden of Disease Study [0.03%]
2023年全球疾病负担研究下的亚太地区慢性乙型肝炎结果分析
Zhengzhao Lu,Dong Xu,Wei Ji et al.
Zhengzhao Lu et al.
Background and aims: The Asia-Pacific region accounts for a larger share of the hepatitis B burden than any other regions of the world, presenting a challenge to meeting the World Health Organization (WHO) 2030 eliminatio...
Antimitochondrial Antibody Measurements in the Diagnosis of Antimitochondrial Antibody-negative and Alkaline Phosphatase-positive Primary Biliary Cholangitis: An Update and Review [0.03%]
抗线粒体抗体阴性和碱性磷酸酶阳性的原发性胆汁性胆管炎患者中抗线粒体抗体检测的诊断价值：更新与综述
Karol Suchowiecki,George Y Wu
Karol Suchowiecki
Antimitochondrial antibody (AMA)-negative primary biliary cholangitis (PBC) is a rare presentation of PBC that comprises 5%-10% of all PBC patients. The pathogenesis of AMA-negative PBC appears to be similar to that of AMA-positive PBC. AMA...
GSTM3 Knockdown Promotes Liver Fibrosis Reversal by Inhibiting Hepatic Stellate Cell Activation via PPARγ Signaling [0.03%]
GSTM3敲低通过PPARγ信号抑制肝星状细胞活化促进肝纤维化的逆转
Chenxue Hou,Bingqing Yang,Yuanying Zhao et al.
Chenxue Hou et al.
Background and aims: Liver fibrosis is a pivotal and reversible stage in the progression of chronic liver disease. However, the mechanisms underlying fibrosis reversal remain unclear, and effective diagnostic biomarkers a...
Dubin-Johnson and Rotor Syndromes: A Review and Update of Pathophysiological Mechanisms [0.03%]
杜宾-约翰逊和Rotor综合征：病理生理机制的综述与更新
Bianca Thakkar,George Y Wu
Bianca Thakkar
Dubin-Johnson syndrome (DJS) and Rotor syndrome (RS) are rare, autosomal recessive disorders that result in chronic, predominantly conjugated hyperbilirubinemia without cholestasis or hepatocellular injury. Although both conditions are beni...