Treatment of Symptomatic Male Hypogonadism with New Oral Testosterone Therapies: A Comparative Review of Jatenzo, Tlando, and Kyzatrex [0.03%]
新口服睾酮疗法治疗症状性男性低促性腺激素性腺功能减退症：Jatenzo、Tlando和Kyzatrex比较分析
Samantha H Rosen,Kian Asanad
Samantha H Rosen
Symptomatic male hypogonadism, defined by low serum testosterone with associated clinical symptoms, is increasingly treated with testosterone replacement therapy. Traditional oral formulations were limited by hepatotoxicity and poor bioavai...
Preliminary Evaluation of an Injectable Therapeutic for Cisplatin Ototoxicity Using Neuronal SH-SY5Y Cells [0.03%]
用于评估顺铂耳毒性的可注射型治疗药物的初步研究（使用神经元SH-SY5Y细胞）
Michelle Hong,Katherine Kedeshian,Larry Hoffman et al.
Michelle Hong et al.
Background/objectives: Though ototoxic, cisplatin is a mainstay of chemotherapy for a variety of cancers. One suggested mechanism of cisplatin ototoxicity involves damage to the spiral ganglion afferent neurons in the inn...
Identification of Active Components in Connarus ruber Extract Exhibiting Anti-Glycation Effects [0.03%]
Connarus ruber提取物抗糖化活性成分的研究
Ryoji Taniguchi,Ryusuke Nakatsuka,Yuka Sasaki et al.
Ryoji Taniguchi et al.
Background: Glycation, a non-enzymatic reaction between sugars and biomolecules, leads to the formation of advanced glycation end-products (AGEs), which are implicated in the progression of chronic diseases. Connarus rube...
Paraskevi Keramida,Nikolaos K Syrigos,Marousa Kouvela et al.
Paraskevi Keramida et al.
Drug repurposing is the process of discovering new therapeutic indications for already existing drugs. By using already approved molecules with known safety profiles, this approach reduces the time, costs, and failure rates associated with ...
Cannabis Use and Analgesic Prescribing in UK Primary Care: A Retrospective Cohort Study of Patients with Osteoarthritis [0.03%]
英国初级保健中的大麻使用及止痛药处方：骨关节炎患者的回顾性队列研究
Simon Erridge,Joht Singh Chandan,Krishna M Gokhale et al.
Simon Erridge et al.
Objectives: This study aims to assess differences in analgesia prescribing in UK primary care between individuals with osteoarthritis who have a recorded exposure to cannabis use and those who do not. ...
HDAC5 Inhibition as a Therapeutic Strategy for Titin Deficiency-Induced Cardiac Remodeling: Insights from Human iPSC Models [0.03%]
组蛋白去乙酰化酶5抑制作为治疗Titin缺乏引起的心脏重塑的潜在策略：来自人类iPSC模型的启示
Arif Ul Hasan,Sachiko Sato,Mami Obara et al.
Arif Ul Hasan et al.
Background/objectives: Dilated cardiomyopathy (DCM) is a prevalent and life-threatening heart muscle disease often caused by titin (TTN) truncating variants (TTNtv). While TTNtvs are the most common genetic cause of herit...
Levosimendan in Decompensated Heart Failure with Reduced Ejection Fraction in Older Adults: A Systematic Review of Safety and Efficacy [0.03%]
左西孟丹治疗老年射血分数降低的失代偿性心力衰竭的安全性和有效性系统评价
Esteban Zavaleta-Monestel,Jeaustin Mora-Jiménez,Kevin Cruz-Mora et al.
Esteban Zavaleta-Monestel et al.
Background/objectives: Heart failure with reduced ejection fraction (HFrEF) is a leading cause of hospitalization and functional decline in older adults, accounting for over 80% of all heart failure cases. Given the narro...
Impact of Sampling Strategy and Population Model on Bayesian Estimates of Vancomycin AUC in Patients with BMI > 40 kg/m2: A Single-Center Retrospective Study [0.03%]
样本量和人群模型对体重指数＞40kg/m2患者贝那普利药代动力学参数群体Bayesian估计值影响的单中心回顾性研究
Sarah A Ekkelboom,Soraya M Hobart,Laurie J Barten et al.
Sarah A Ekkelboom et al.
Background/Objectives: Growing evidence supports the use of a single trough concentration, rather than both a peak and trough, to estimate the 24 h area under the curve (AUC24) of vancomycin using Bayesian software (InsightRx® Ver.1.71). H...
Checklist-Based Identification of Adverse Drug Reactions in Emergency Department Patients [0.03%]
基于检查表的急诊患者不良反应事件识别方法研究
Benjamin J Hellinger,Thilo Bertsche,Yvonne Remane et al.
Benjamin J Hellinger et al.
Background: Patients presenting at the emergency department (ED) have a wide variety of complaints. In some of those patients a possible reason for their complaints might be an adverse drug reaction (ADR). An appropriate identification of A...
Non-Induction Basiliximab to Facilitate Renal Recovery via Temporary Tacrolimus Cessation in Cardiothoracic Transplant Patients [0.03%]
非诱导 basiliximab 在心脏和胸部移植患者中通过暂时停用他克莫司促进肾小球滤过率恢复的安全性：一项前瞻性研究
Tanner A Melton,Molly W Fenske,Stacy A Bernard et al.
Tanner A Melton et al.
Introduction: Reversible and irreversible nephrotoxicity are known complications of tacrolimus. Approaches to reduce the incidence of nephrotoxicity include the reduction or avoidance of tacrolimus but must be weighed against risk of reject...