Nickel(II) N-Heterocyclic Carbene Complex for the Hydrogenation of 2-Acetylpyridine under Mild Conditions [0.03%]
温和条件下2-乙酰基吡啶氢化的镍(ii)氮杂环卡宾配合物
Mitu Sharma,Amanda M Perkins,Alison K Duckworth et al.
Mitu Sharma et al.
Catalyst-mediated hydrogenation of ketones via hydride transfer can be directly used in the synthesis of alcohols which can exhibit great potential in the practical synthesis of pharmaceuticals. The application of Ni-NHC complexes in the hy...
The Cryptic Nature of Fe-S Clusters: A Case Study of the Hepatitis B HBx Oncoprotein [0.03%]
铁硫簇的神秘特性：乙型肝炎HBx致癌蛋白的一个实例研究
Trent Quist,Jiahua Chen,Alex MacNeil et al.
Trent Quist et al.
Fe-S clusters are ubiquitous inorganic cofactors found in proteins across all domains of life, including viruses. Their prevalence stems from their unique redox and structural plasticity that supports functions ranging from electron transfe...
Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends [0.03%]
基于铜的抗生素策略：探讨在医院环境中的应用、靶向铜调控通路及当前药物设计趋势
Aixa M Orta-Rivera,Yazmary Meléndez-Contés,Nataniel Medina-Berríos et al.
Aixa M Orta-Rivera et al.
Classical antibacterial drugs were designed to target specific bacterial properties distinct from host human cells to maximize potency and selectivity. These designs were quite effective as they could be easily derivatized to bear next-gene...
Exploring the Use of Intracellular Chelation and Non-Iron Metals to Program Ferroptosis for Anticancer Application [0.03%]
探究利用胞内螯合及非铁金属来调控铁死亡用于抗肿瘤应用
Oscar Claudio-Ares,Jeileen Luciano-Rodríguez,Yolmarie L Del Valle-González et al.
Oscar Claudio-Ares et al.
The discovery of regulated cell death (RCD) revolutionized chemotherapy. With caspase-dependent apoptosis initially being thought to be the only form of RCD, many drug development strategies aimed to synthesize compounds that turn on this k...
Pentadentate and Hexadentate Pyridinophane Ligands Support Reversible Cu(II)/Cu(I) Redox Couples [0.03%]
五齿和六齿吡啶花环配体可支持可逆的Cu（II）/Cu（I）氧化还原对
Glenn Blade,Andrew J Wessel,Karna Terpstra et al.
Glenn Blade et al.
Two new ligands were synthesized with the goal of copper stabilization, N,N'-(2-methylpyridine)-2,11-diaza[3,3](2,6)pyridinophane (PicN4) and N-(methyl),N'-(2-methylpyridine)-2,11-diaza[3,3](2,6)pyridinophane (PicMeN4), by selective functio...
pH Dependent Reversible Formation of a Binuclear Ni2 Metal-Center Within a Peptide Scaffold [0.03%]
在肽支架中pH依赖的双核Ni2金属中心的可逆形成
Brenna C Keegan,Daniel Ocampo,Jason Shearer
Brenna C Keegan
A disulfide-bridged peptide containing two Ni2+ binding sites based on the nickel superoxide dismutase protein, {Ni2(SODmds)}, has been prepared. At physiological pH (7.4) it was found that the metal sites are mononuclear with a square plan...
Exploring Serum Transferrin Regulation of Nonferric Metal Therapeutic Function and Toxicity [0.03%]
探索血清转铁蛋白对非铁金属治疗功能和毒性的调节作用
Josué A Benjamín-Rivera,Andrés E Cardona-Rivera,Ángel L Vázquez-Maldonado et al.
Josué A Benjamín-Rivera et al.
Serum transferrin (sTf) plays a pivotal role in regulating iron biodistribution and homeostasis within the body. The molecular details of sTf Fe(III) binding blood transport, and cellular delivery through transferrin receptor-mediated endoc...
Cytochrome c: Using Biological Insight toward Engineering an Optimized Anticancer Biodrug [0.03%]
细胞色素c：利用生物学见解工程化优化的抗癌生物药物
Louis J Delinois,Omar De León-Vélez,Adriana Vázquez-Medina et al.
Louis J Delinois et al.
The heme protein cytochrome c (Cyt c) plays pivotal roles in cellular life and death processes. In the respiratory chain of mitochondria, it serves as an electron transfer protein, contributing to the proliferation of healthy cells. In the ...
Metal-Dithiolene Bonding Contributions to Pyranopterin Molybdenum Enzyme Reactivity [0.03%]
二硫醇盐配体对吡喃辅酶钼酶活性的影响
Jing Yang,John H Enemark,Martin L Kirk
Jing Yang
Here we highlight past work on metal-dithiolene interactions and how the unique electronic structure of the metal-dithiolene unit contributes to both the oxidative and reductive half reactions in pyranopterin molybdenum and tungsten enzymes...
Human acireductone dioxygenase (HsARD), cancer and human health: Black hat, white hat or gray? [0.03%]
人源丙酮酸內氧化酶(HsARD)与癌症和人类健康：黑帽子、白帽子还是灰帽子？
Xinyue Liu,Thomas C Pochapsky
Xinyue Liu
Multiple factors involving the methionine salvage pathway (MSP) and polyamine biosynthesis have been found to be involved in cancer cell proliferation, migration, invasion and metastasis. This review summarizes the relationships of the MSP ...