Decoding ovarian aging in women: Cellular damage, signaling networks, and treatment frontiers [0.03%]
女性卵巢衰老的分子机理及临床干预策略展望
Shivani Ingole,Kanchan Khare,Veepin Dwivedi et al.
Shivani Ingole et al.
Ovarian aging is a significant biological process characterized by the gradual decline of ovarian function and fertility in women as they age. It is a multifaceted process that involves various molecular mechanisms. This review article delv...
Marilú Cristofoli,Flavia Maria Pia Montenegro Donoso,Mayla Magalhães de Oliveira Alcobaça et al.
Marilú Cristofoli et al.
The rhea (Rhea americana) is a docile and highly adaptable ratite with notable zootechnical potential for the production of meat, eggs, feathers, and leather. Beyond its economic relevance, captive breeding plays an important role in conser...
Controlled ovarian hyperstimulation reduces mouse embryo implantation capacity through uterine HIF-2α mediated pathway [0.03%]
控制性卵巢过度刺激通过子宫HIF-2α介导的途径降低小鼠胚胎着床能力
Zheng Zhi,Haijun Yang,Zhangming Liu et al.
Zheng Zhi et al.
Controlled ovarian hyperstimulation (COH) is a cornerstone of assisted reproductive technologies, yet its effects on endometrial function and embryo implantation remain poorly understood, particularly regarding the role of hypoxia-inducible...
Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics [0.03%]
PET微塑料对男性不育毒理效应的网络毒理学、孟德尔随机化及转录组学生物信息学综合分析研究
Yang Yang,Linfeng Li,Ning Zhang et al.
Yang Yang et al.
Current research indicates that polyethylene terephthalate microplastics (PET-MPs) may significantly impair male reproductive function. This study aimed to investigate the potential molecular mechanisms underlying this impairment. Potential...
Pasteurized Akkermansia muciniphila ameliorates insulin resistance by reducing placental inflammation in GDM mouse model [0.03%]
巴氏消毒剂Akkermansia muciniphila通过减少GDM小鼠模型的胎盘炎症来改善胰岛素抵抗
Yi Wang,Yuting Zhu,Yan Cui et al.
Yi Wang et al.
Gestational diabetes mellitus (GDM) is a common and serious complication during pregnancy. Depleted next-generation probiotic, Akkermansia muciniphila (AKK) in GDM women indicates its potential on GDM prevention. However, the functions and ...
Evaluation of the protective effect of resveratrol-loaded solid lipid nanoparticles on radiation- or doxorubicin-induced spermatogenic damage in mice [0.03%]
白藜芦醇固脂纳米粒对小鼠放射或阿霉素致生精细胞损伤保护作用的评价研究
Mohammad Farhadi Rad,Faranak Aghaz,Khodabakhsh Rashidi et al.
Mohammad Farhadi Rad et al.
Radiation and doxorubicin (Dox) exert destructive effects on testicular tissue. Resveratrol, a natural antioxidant, may protect the spermatogenic system against the toxic effects of these agents. This study evaluated the protective and anti...
The ameliorative effects of L-arginine on testicular and genotoxic toxicity induced by chronic exposure to cadmium chloride in male murine models [0.03%]
L-精氨酸对慢性接触氯化镉诱发的小鼠睾丸和遗传毒性的作用改善效果研究
Nasibeh Hemati,Milad Chahardori,Mohammad Hosseinzadeh et al.
Nasibeh Hemati et al.
Cadmium (Cd) is a toxic heavy metal known to cause DNA damage, genetic alterations, and reproductive issues in males through free radical production. This study investigates L-arginine, an amino acid with antioxidant and metal-chelating pro...
Fisetin attenuates the adverse effects of freezing and thawing procedures on the biological characteristics of human asthenoteratozoospermia samples [0.03%]
杨梅素可减轻冻融操作对弱精症样本生物学特性影响的研究
Daniyal Ezati,Reyhane Vardiyan,Ali Reza Talebi et al.
Daniyal Ezati et al.
Sperm cryopreservation is a conventional method to preserve sperm cells for a long time. This technique may cause various effects on sperm parameters. Therefore, applying beneficial antioxidants to decrease the adverse effects of freezing i...
Molecular docking of nano-curcumin to caspase-3 and caspase-9: Unraveling its cryoprotective mechanism in rabbit sperm extenders [0.03%]
纳米姜黄素与半胱天冬酶-3和半胱天冬酶-9的分子对接：揭示其在兔精稀释液中的胞保护机制
Abdel-Khalek Kh A E,Saima Qadeer,Sh A Gabr et al.
Abdel-Khalek Kh A E et al.
This study aimed to investigate the cryoprotective mechanism of nano-curcumin (CRNPs) on rabbit sperm via molecular docking and to compare the effects of two extenders, Tris-egg yolk (TEYE) and Tris-soybean lecithin (TSBLE) supplemented wit...
Potential novel biomarkers for gestational diabetes mellitus in first and early second trimesters: A comprehensive review [0.03%]
妊娠期糖尿病潜在新型生物标志物：全面综述
Rabail Azhar Iqbal,Sophia Nazir
Rabail Azhar Iqbal
Gestational diabetes mellitus (GDM) is one of the commonly encountered medical disorders of pregnancy affecting women of childbearing age globally at an alarming rate and causing significant perinatal morbidity and adverse fetal outcomes. T...