Metformin-loaded Chitosan nanoparticles alleviate insulin resistance in the polycystic ovarian syndrome rat model through modulation of PI3K/AKT/ GLUT4 in ovarian tissue
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Polycystic ovary syndrome (PCOS) is a common disorder in females characterized by insulin resistance (IR), hyperandrogenemia and anovulation. The etiology of PCOS is unknown. However, disrupted phosphatidylinositol 3-kinase (PI3K) and protein kinase B/AKT sign... ...
