Regulation of IRE1α by the small molecule inhibitor 4μ8c in hepatoma cells [0.03%]
4μ8c通过抑制IRE1α通路来诱导肝癌细胞凋亡
Claire Stewart,Andrea Estrada,Paul Kim et al.
Claire Stewart et al.
The unfolded protein response (UPR) is activated in response to impairments of the folding environment in the endoplasmic reticulum (ER). The most conserved arm of the UPR, inositol-requiring ER-to-nucleus signaling protein (IRE1α), has be...
α1-antitrypsin Deficiency: A Misfolded Secretory Protein Variant with Unique Effects on the Endoplasmic Reticulum [0.03%]
α1-抗胰蛋白酶缺乏症：一种影响内质网的错误折叠分泌型蛋白质变异体
David H Perlmutter
David H Perlmutter
In the classical form of α1-antitrypsin deficiency (ATD) a point mutation leads to accumulation of a misfolded secretory glycoprotein in the endoplasmic reticulum (ER) of liver cells and so ATD has come to be considered a prototypical ER s...
Patrick Lajoie,Elena N Fazio,Erik L Snapp
Patrick Lajoie
The endoplasmic reticulum (ER) is the point of entry of proteins into the secretory pathway. Nascent peptides interact with the ER quality control machinery that ensures correct folding of the nascent proteins. Failure to properly fold prot...
Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis [0.03%]
蛋白质二硫异构酶超家族与疾病及细胞凋亡调控的关系
C Grek,D M Townsend
C Grek
Cellular homeostasis requires the balance of a multitude of signaling cascades that are contingent upon the essential proteins being properly synthesized, folded and delivered to appropriate subcellular locations. In eukaryotic cells the en...