Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling [0.03%]
α-生育酚和二甲双胍通过调节TLR2信号通路缓解实验性胰岛素抵抗和认知缺陷
Swati Ahuja,Ankit Uniyal,Ansab Akhtar et al.
Swati Ahuja et al.
Background: Obesity is commonly found to be co-morbid with type 2 Diabetes Mellitus. In obese diabetic patients, TLR-2 receptor induced inflammation leads to the development of insulin resistance (IR). Furthermore, the IR...
Protective effects of polydatin in free and nanocapsulated form on changes caused by lipopolysaccharide in hippocampal organotypic cultures [0.03%]
茋类化合物白黎芦醇棓酯及其纳米胶束化修饰对其海马脑切片LPS损伤的保护作用研究
Agnieszka Basta-Kaim,Joanna Ślusarczyk,Krzysztof Szczepanowicz et al.
Agnieszka Basta-Kaim et al.
Background: Polydatin (PD) is a compound, originally isolated from the root and rhizome of the Chinese herb Polygonum cuspidatum. To date, various biological properties of this compound, such as analgesic, anti-pyretic or...
Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice [0.03%]
多柔比星所致小鼠睾丸损伤与PARP-1信号分子有关
Nazli Ece Gungor-Ordueri,Nilay Kuscu,Arda Tasatargil et al.
Nazli Ece Gungor-Ordueri et al.
Background: Doxorubicin (DOX), is a chemotherapeutic agent, which evokes oxidative stress and cell apoptosis in testicular tissue. It is known that the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP),...
Daniel J M Medeiros-Lima,Jorge J Carvalho,Eduardo Tibirica et al.
Daniel J M Medeiros-Lima et al.
Background: Doxorubicin (DOX)-related cardiotoxicity may expose cancer survivors to increased risk of cardiovascular morbidity and mortality. Here, we characterized the time course of DOX-induced cardiomyopathy in rats. ...
Analgesic adjuvants modulate morphine-induced immune effects in mice [0.03%]
analgesic adjuvants 调节阿片类药物诱导的小鼠免疫效应
Michael Kozlowski,Katarzyna Nazimek,Bernadeta Nowak et al.
Michael Kozlowski et al.
Background: Macrophages, involved in the pathogenesis of pain, express a variety of receptors enabling responsiveness to certain medications, including adjuvant analgesics (AAs), that are effective in neuropathic pain and...
Effect of TRPA1 activator allyl isothiocyanate (AITC) on rat dural and pial arteries [0.03%]
异硫氰酸烯丙酯(AITC)激活剂对大鼠硬脑膜和软脑膜动脉的影响
Anna Koldbro Hansted,Deepak Kumar Bhatt,Jes Olesen et al.
Anna Koldbro Hansted et al.
Background: Transient receptor potential ankyrin 1 (TRPA1) channels may have a role in migraine as some substances known to cause headache activate the channel. In the craniovascular system such activation causes a calcit...
PPAR-γ agonist pioglitazone reduces microglial proliferation and NF-κB activation in the substantia nigra in the 6-hydroxydopamine model of Parkinson's disease [0.03%]
PPAR-γ激动剂吡格列酮减少帕金森病6-羟基多巴胺模型黑质微胶质增殖和NF-κB活化
Meira Maria Forcelini Machado,Taysa Bervian Bassani,Valentín Cóppola-Segovia et al.
Meira Maria Forcelini Machado et al.
Background: Peroxisome proliferator-activated receptor γ (PPAR-γ) agonists have received much attention in research because of their neuroprotective and anti-inflammatory effects that reduce cell death and halt the prog...
Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice [0.03%]
GW9508抗动脉粥样硬化作用及其对apoE基因敲除小鼠的促脂肪酸氧化效应
Maciej Suski,Anna Kiepura,Anna Wiśniewska et al.
Maciej Suski et al.
Background: In the past two decades, enhanced understanding of the biology of G-protein-coupled receptors (GPRs) has led to the identification of several such receptors as novel targets for free fatty acids (FFAs). Two GP...
The inhibition effects of some sulfonamides on human serum paraoxonase-1 (hPON1) [0.03%]
一些磺酰胺类药物对人血清红磷脂酶-1的抑制作用
Yeliz Demir,Zeynep Köksal
Yeliz Demir
Background: Paraoxonase 1 (PON1) is an antiatherogenic and organophosphate hydrolyzer enzyme. It has important roles including protecting low density lipoprotein (LDL) against oxidation and the detoxification of highly to...
Transcriptome-based identification of lovastatin as a breast cancer stem cell-targeting drug [0.03%]
基于转录组的他汀类药物Lovastatin靶向乳腺癌干细胞的研究
Luz X Vásquez-Bochm,Mireya Velázquez-Paniagua,Sandra S Castro-Vázquez et al.
Luz X Vásquez-Bochm et al.
Background: Breast cancer is a neoplastic disease with high morbidity and mortality in women worldwide. Breast cancer stem cells (CSCs) have a significant function in tumor growth, recurrence, and therapeutic resistance. ...