Pre-treatment with 2-mercaptoethanol attenuates ferroptosis-associated redox imbalance and inflammatory responses, but not tubulointerstitial fibrosis, in unilateral ureteral obstruction [0.03%]
2-巯乙醇预处理缓解了单侧输尿管梗阻所致的铁死亡相关氧化应激和炎症反应，但不能减轻肾间质纤维化
Daeun Moon,Jinu Kim
Daeun Moon
Background: Unilateral ureteral obstruction (UUO) induces oxidative stress, inflammation, ferroptosis, and progressive fibrotic remodeling. Whether pharmacological modulation of ferroptosis-related redox imbalance attenua...
Population pharmacokinetics of total and free mycophenolic acid in plasma in paediatric patients with nephrotic syndrome including salivary concentrations and the pharmacodynamics [0.03%]
儿童肾病综合征患者环孢素血浆总产物及游离产物群体药代动力学包括唾液浓度和药效学研究
Astrid Heida,Danuta Ostalska-Nowicka,Jacek Zachwieja et al.
Astrid Heida et al.
Background: Therapeutic drug monitoring (TDM) may optimize dosing of mycophenolate mofetil (MMF) in patients with nephrotic syndrome, but it is not routinely implemented. When performed, TDM typically relies on total myco...
Elevated hypoxia-inducible factor-1α in pediatric patients with patent ductus arteriosus: a pilot study [0.03%]
动脉导管未闭患儿血清缺氧诱导因子-1α水平升高：一项初步研究
Oksana Trębacz,Patrycja Florek,Jacek Podlewski et al.
Oksana Trębacz et al.
Background: Children with complex cyanotic congenital heart disease (CHD) and with pulmonary hypertension (PH) commonly experience hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of cellular responses t...
Retraction Note: Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2 [0.03%]
撤回 notice: 纳比洛尔在急性肾损伤大鼠模型中的肾脏保护作用：钠葡萄糖共转运蛋白的作用机制
Ahmed M Nasr,Samar Rezq,Aya Shaheen et al.
Ahmed M Nasr et al.
Multi-target-directed drugs: new additions in 2025 and post-marketing safety surveillance of drugs marketed in 2022-2024 [0.03%]
多靶标药物：2025年新增药品及2022-2024年上市药物的上市后安全监测
Piotr Ryszkiewicz,Marta Baranowska-Kuczko,Barbara Malinowska et al.
Piotr Ryszkiewicz et al.
Polypharmacology is dedicated to the development of compounds acting on at least two targets (multi-target-directed ligands, MTDLs). In 2025, the European Medicines Agency (EMA) approved 38 drugs, and 11 out of them were MTDLs. Most of them...
Aripiprazole modulates splenic microbiota and immune response elicited by single prolonged stress in rats [0.03%]
阿利哌唑调节单次长时间应激大鼠脾脏微生物组并缓解免疫反应
Peter Vargovic,Andrej Tillinger,Lubica Horvathova et al.
Peter Vargovic et al.
Background: Post-traumatic stress disorder (PTSD) is associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympatho-adrenomedullary system, leading to immune imbalance and alterations in m...
Phase-specific involvement of BDNF-TrkB signaling in HSV-1-induced herpetic pain and its transition to postherpetic neuralgia-like pain [0.03%]
BDNF-TrkB信号在HSV-1诱导的带状疱疹痛及其向带状疱疹后神经痛样疼痛转变中的阶段特异性作用
Ichiro Takasaki,Arata Inoue,Aoi Yoshida et al.
Ichiro Takasaki et al.
Background: Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that develops following herpes zoster, yet the molecular mechanisms underlying the transition from acute herpetic pain to chronic pain remai...
The onset of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) with the use of decongestant agents: a European pharmacovigilance analysis [0.03%]
欧洲药物警戒分析：使用减充血剂后发生可逆性脑病综合征(PRES)和可逆性脑血管收缩综合征(RCVS)的起因
Antonietta Anatriello,Andrea Cantone,Ciro Pentella et al.
Antonietta Anatriello et al.
Background: On December 1st, 2023, the Pharmacovigilance Risk Assessment Committee (PRAC) published a safety warning against using pseudoephedrine in patients with severe or uncontrolled hypertension and severe acute or c...
The Wistar-Kyoto rat as a model relevant to inattentive ADHD: substrain variability and affective comorbidity [0.03%]
关于多动症的_WAKE大鼠模型：亚系变化及情感障碍的相关性
Natalia Gaik,Emil Dzierkacz,Agata Faron-Górecka
Natalia Gaik
Wistar-Kyoto (WKY) rats, originally used as a control group for spontaneously hypertensive rats, are increasingly recognized as a valuable model for studying selected neuropsychiatric disorders. This strain exhibits behavioral and neurobiol...
Topical latanoprost acid for female androgenetic alopecia: a pilot proof-of-concept trial with mechanistic evidence of prostaglandin F2α receptor activation [0.03%]
用于女性雄激素性脱发的拉坦前列腺素酸滴眼液：一项概念验证试验及机制证据显示前列腺素F2α受体激活作用
Adriana Rakowska,Małgorzata Dutkiewicz,Oliwia Zegrocka-Stendel et al.
Adriana Rakowska et al.
Background: Prostaglandin F2α receptor (FP receptor) signaling is a plausible target for promoting hair growth, but clinical data on topical latanoprost acid (the active free-acid FP agonist) in hair loss are lacking. Th...