Antioxidant activities and molecular docking of 2-thioxobenzo[g]quinazoline derivatives [0.03%]
2-硫代苯并〔g〕喹唑啉衍生物的抗氧化活性及分子对接研究
Rashad Al-Salahi,Hanan A A Taie,Ahmed H Bakheit et al.
Rashad Al-Salahi et al.
Background: Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the d...
Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin [0.03%]
通过靶向白喉素和IL-1α来预防非酒精性脂肪肝炎中的卢丁的作用
Nashwa Abu-Elsaad,Amr El-Karef
Nashwa Abu-Elsaad
Background: The management of nonalcoholic steatohepatitis (NASH) is still a crosstalk so the current study was designed to evaluate the effect of different luteolin doses on an experimental model of NASH and to elucidate...
Cardioprotective effects of cerebrolysin on the lesion severity and inflammatory factors in a rat model of isoproterenol-induced myocardial injury [0.03%]
脑活素对异丙肾上腺素致大鼠心肌损伤模型损伤严重程度及炎性因子的影响研究
Abolfazl Ardjmand,Mohammad Esmaeil Shahaboddin,Tahere Mazoochi et al.
Abolfazl Ardjmand et al.
Background: Myocardial injury (MI) is an important heart condition and a major cause of morbidity and mortality worldwide. The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) o...
Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist [0.03%]
DMPX（一种选择性的腺苷A2A受体拮抗剂）而不是DPCPX（一种选择性腺苷A1受体拮抗剂）能够增强阿戈美拉汀和曲坦普特在小鼠绝望行为试验中的抗抑郁活性
Aleksandra Szopa,Karolina Bogatko,Anna Serefko et al.
Aleksandra Szopa et al.
Background: Adenosine, an endogenous nucleoside, modulates the release of monoamines, e.g., noradrenaline, serotonin, and dopamine in the brain. Both nonselective and selective stimulation of adenosine receptors produce s...
Oral administration of BDNF and/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study [0.03%]
口服BDNF和/或GDNF可使嗅球切除大鼠脑内BDNF水平恢复正常：概念验证性研究
Jan Kucera,Jana Ruda-Kucerova,Filip Zlamal et al.
Jan Kucera et al.
Background: Neurotrophins, especially brain-derived neurotrophic factor (BDNF) have gained significant therapeutic interest particularly in neurologic and psychiatric disorders and they have been found in human breast mil...
Sildenafil corrects the increased contractility of rat detrusor muscle induced by alprostadil in vitro [0.03%]
西地那非纠正铝前列腺素诱发的大鼠膀胱逼尿肌收缩过度的症状
Wesam Bassiouni,Amira Senbel,Xavier Norel et al.
Wesam Bassiouni et al.
Background: Sildenafil (PDE5-inhibitor) and alprostadil (PGE1) are used in combination clinically for the management of some cases of erectile dysfunction. Despite the roles of prostaglandins (PG) and nitric oxide (NO) pa...
Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells [0.03%]
柑橘黄酮类化合物3，5，6，7，8，3'，4'-庚甲氧基黄酮通过cAMP/ERK/CREB信号诱导C6细胞中的BDNF并降低磷酸二酯酶活性
Atsushi Sawamoto,Satoshi Okuyama,Mitsunari Nakajima et al.
Atsushi Sawamoto et al.
Background: Brain-derived neurotrophic factor (BDNF) is associated with onset of several central nervous system disorders, e.g., Parkinson's disease, Alzheimer's disease, depression, epilepsy, and chronic pain. In our pre...
Potential phytochemicals in the prevention and treatment of esophagus cancer: A green therapeutic approach [0.03%]
植物化学物质在预防和治疗食道癌方面的潜在作用：一种绿色的治疗方法
Banzeer Ahsan Abbasi,Javed Iqbal,Riaz Ahmad et al.
Banzeer Ahsan Abbasi et al.
Globally, esophagus cancer (EC) is one of the most frequently reported malignancies and leading cause of deaths. Currently, different treatment methods are available like chemotherapy, radiation therapy, surgery or their combination. These ...
Agnieszka Piechal,Izabela Domitrz,Iwona Kurkowska-Jastrzębska et al.
Agnieszka Piechal et al.
Migraine is one of the most common disorders found in everyday clinical practice. Although migraines are not directly life-threatening or permanently disabling, the severity of the pain and symptoms that characterize a migraine attack often...
Does kisspeptin participate in GABA-mediated modulation of GnRH and GnRH receptor biosynthesis in the hypothalamic-pituitary unit of follicular-phase ewes? [0.03%]
催产素阶段母羊下丘脑-垂体单位中kisspeptin参与GABA介导的GnRH及GnRH受体生物合成的调节？
Magdalena Olga Ciechanowska,Magdalena Łapot,Marek Kowalczyk et al.
Magdalena Olga Ciechanowska et al.
Background: The inverse relationship between GnRH transcript level and GABA neurons activity has suggested that GABA at the hypothalamic level may exert a suppressive effect on subsequent steps of the GnRH biosynthesis. I...