Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia [0.03%]
一种集成计算与实验的方法鉴定脑缺血条件下Nrf2调节的分子靶点
Anita Lewczuk,Anna Boratyńska-Jasińska,Łukasz Charzewski et al.
Anita Lewczuk et al.
Background: The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the cellular antioxidant response, playing an important role in protecting neurons from ischemic injury. The...
Anna Julia Krupa,Magdalena Zybała-Pawłowska,Michał Kania et al.
Anna Julia Krupa et al.
Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induced colitis-associated cancer mouse model [0.03%]
KR-12及其短链脂肪酸衍生物的合成与评价：在偶氮甲烷/葡聚糖硫酸钠诱导的结肠炎相关结直肠癌小鼠模型中的选择性细胞毒性和抗肿瘤活性
Jakub Włodarczyk,Elżbieta Kamysz,Jakub Fichna
Jakub Włodarczyk
Background: Colorectal cancer (CRC) remains a major global health challenge, with increasing incidence, particularly among individuals under 50 years of age. Cathelicidin LL-37, a multifunctional antimicrobial peptide, ha...
Solcumin™: a functional hybrid particle with potent anti-inflammatory and antioxidant activities and enhanced storage stability [0.03%]
Solcumin™：一种具有强大的抗炎和抗氧化活性及增强的储存稳定性的功能型复合粒子
Jinhee Jeong,Sujin Hwang,Chan Hee Lee et al.
Jinhee Jeong et al.
Background: Separation and encapsulation provide a practical and effective strategy for the targeted delivery of bioactive components in formulation technologies. This study aimed to develop an inorganic Pickering-mediate...
Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis [0.03%]
尿苷在脑和肠道健康中的作用：通过肠-脑轴探讨其神经保护潜力的见解
Birnur Aydin,Mehmet Cansev
Birnur Aydin
The intricate interplay between the brain and gut, often referred to as the gut-brain axis, has emerged as a cornerstone of health and disease. This bidirectional communication network, mediated by neural, hormonal, immune, and microbial si...
Tyrosine kinase 2 inhibitors in the therapy of inflammatory and autoimmune diseases [0.03%]
janus激酶和酪氨酸蛋白 kinase 2抑制剂在炎症及自身免疫性疾病治疗中的应用
Patryk Rzeczycki,Martyna Plust,Paulina Plewa et al.
Patryk Rzeczycki et al.
Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study [0.03%]
帕博西尼治疗内分泌原发耐药转移性乳腺癌患者：基于基因多态性的研究
Abdel-Hameed Ibrahim Mohamed Ebid,Yasmine Magdy Fahim Genina,Hesham Haffez et al.
Abdel-Hameed Ibrahim Mohamed Ebid et al.
Current advances in the management of hepatic encephalopathy: an updated and critical review [0.03%]
肝性脑病治疗的新进展：更新与批判式回顾
Bilal El-Mansoury,Hicham Esselmani,Mohamed Merzouki et al.
Bilal El-Mansoury et al.
Hepatic encephalopathy (HE) is a serious and potentially reversible neuropsychiatric syndrome resulting from severe liver insufficiency. HE is primarily considered a gliopathy in which astrocyte dysfunction is the main neuropathological hal...
Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring [0.03%]
母体单糖饮食可调节大鼠后代黑皮质素受体4信号通路及代谢状态
Kacper Witek,Karolina Wydra,Agata Suder et al.
Kacper Witek et al.
Mina Y George,Sherif S Abdel Mageed,Daniel E Mansour et al.
Mina Y George et al.