Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and - 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol [0.03%]
普萘洛尔治疗婴幼儿血管瘤患者早期血浆HIF-1α、基质金属蛋白酶-2和-9及基质金属蛋黎明抑制剂-1的变化
Małgorzata Kowalska,Olga Martyna Koper-Lenkiewicz,Joanna Kamińska et al.
Małgorzata Kowalska et al.
Background: Infantile hemangiomas (IH) are the most prevalent benign vascular tumors diagnosed in the pediatric population. Propranolol, a nonselective beta-adrenergic receptor antagonist, is the first-line treatment for ...
Gut microbiota in anxiety and depression: mechanisms, drug interactions, and therapeutic implications [0.03%]
肠道菌群与焦虑抑郁的关系：机制、药物相互作用及治疗意义
Hanane El Fatimi,Bilal El-Mansoury,Anass Tinakoua et al.
Hanane El Fatimi et al.
Anxiety and depressive disorders constitute a public health concern with a high negative impact on patients' quality of life. These disorders are among the prevalent neuropsychiatric conditions significantly contributing to the global burde...
Anthracyclines as diagnostic stressors: mitophagy signaling and hidden cardiac vulnerability [0.03%]
蒽环类药物作为诊断性应激源：线粒体自噬信号与隐藏的心脏脆弱性
Natalia Kulicka,Artur Dziewierz
Natalia Kulicka
Anthracyclines are cornerstone agents in oncology, yet their cardiotoxic effects may do more than inflict damage-they may uncover latent cardiac vulnerabilities. This mini-review examines anthracycline-induced mitochondrial stress as a pote...
Cobalt protoporphyrin IX induces transient, dose- and time-dependent granulocyte mobilization with mild metabolic effects in mice [0.03%]
氯化钴诱导的小鼠体内的血代谢变化及机理研究
Aleksandra Bednarz,Paweł Kożuch,Kacper Kowalski et al.
Aleksandra Bednarz et al.
Background: Recombinant granulocyte colony-stimulating factor (G-CSF) is the most commonly used agent for treating neutropenia and mobilizing hematopoietic stem cells (HSCs) for transplantation. However, some patients do ...
Behavioral tests to assess short- and long-lasting sensorimotor deficits following transient focal cerebral ischemia in rodents [0.03%]
用于评估短暂性局灶性脑缺血后小鼠短期内及长期的感官运动缺陷的行为学检测方法
Enrique García-Alfonso,Jeney Ramírez-Sánchez,Maylin Wong-Guerra et al.
Enrique García-Alfonso et al.
Cerebrovascular diseases are highly lethal and disabling events. Stroke is most commonly modeled using focal ischemia, of which middle cerebral artery occlusion (MCAO) is widely employed. Reproducible and reliable animal models are crucial ...
Correction: Marizomib in the therapy of brain tumors-how far did we go and where do we stand? [0.03%]
马里佐米滨在脑肿瘤治疗中的作用——我们走了多远，现在处于什么位置？纠正文章
Magdalena Kusaczuk,Wiktoria Monika Piskorz,Julia Domasik
Magdalena Kusaczuk
Published Erratum
Pharmacological reports : PR. 2025 Jun 27. DOI:10.1007/s43440-025-00755-0 2025
The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo [0.03%]
胆碱能和mGlu受体调节剂对MK-801所致一氧化氮依赖性过程损伤的影响：体内外研究
Grzegorz Burnat,Michał Santocki,Leszek Kalinowski et al.
Grzegorz Burnat et al.
Background: Schizophrenia is a mental disorder with multifactorial etiology including positive, negative and cognitive symptoms. Nitric oxide (NO֗)-related biochemical pathways significantly contribute to the disease's p...
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes [0.03%]
一种新的2-氧化吡咯烷衍生物(LN-53)有效诱导人表皮角质细胞中Nrf-2信号通路的激活
Basak Ezgi Sarac,Laura Nissim,Dilara Karaguzel et al.
Basak Ezgi Sarac et al.
Background: The skin is a pivotal organ that serves as a physical barrier, protecting the body from harmful substances such as pathogens, allergens, and other environmental irritants. Chronic inflammation in the skin, alo...
Exploring the pharmacological mechanisms and therapeutic implications of galangin against neurological disorders [0.03%]
探讨姜黄素的药理机制及其对神经疾病的治疗意义
Xueying Zhang,Guangcheng Zhong,Haike Wu
Xueying Zhang
Neurological disorders represent a leading cause of mortality and disability worldwide, encompassing a broad spectrum of prevalent conditions such as Alzheimer's disease, epilepsy, and stroke. In recent years, natural compounds have garnere...
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results [0.03%]
稳定期慢性阻塞性肺疾病患者的碘甲状腺氨酸脱碘酶的初步研究结果
Elżbieta Małujło-Balcerska,Anna Kumor-Kisielewska,Maria Gałecka et al.
Elżbieta Małujło-Balcerska et al.
Background: Different immune/inflammatory molecules play key roles in the development of inflammatory diseases, including chronic obstructive pulmonary disease (COPD). Thyroid hormones (THs) participate in immune/inflamma...