New molecules candidates with a semicarbazide scaffold - anticancer potential in view of research on their physicochemical properties, antioxidant activity, and preliminary biological activity [0.03%]
具有抗癌症潜力的半碳酰肼衍生物的新分子候选物-基于其理化性质，抗氧化活性及初步生物学活性的研究视角
Łucja Justyna Walczak,Marta Arczewska,Zbigniew Karczmarzyk et al.
Łucja Justyna Walczak et al.
Isoxazole derivatives as multi-target agents: virucidal, antibacterial, and antiproliferative effects on skin cancer cells [0.03%]
异唑衍生物作为多靶点药物：抗病毒、抗菌及对皮肤癌细胞的抗增殖作用
Izabela Jęśkowiak-Kossakowska,Paulina Nowotarska,Elżbieta Gębarowska et al.
Izabela Jęśkowiak-Kossakowska et al.
Background: The convergence of microbial infections and cancer risk in inflammatory skin diseases demands novel, multi-functional therapeutics. This challenge is exacerbated by the rise in antimicrobial resistance and the...
Propafenone-mediated gap junctional uncoupling results from aberrant connexin-43 trafficking [0.03%]
丙吡胺介导的缝隙连接解偶联由异常的连接蛋白43转运引起
Encan Li,Najla Boujeddaine,Britt Mol et al.
Encan Li et al.
Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours [0.03%]
实现重症患者β-内酰胺类抗生素目标血药浓度的回顾性研究——早期（24小时内）足量应用的效果分析
Milada Halačová,Marie Mieresová,Jan Kubele et al.
Milada Halačová et al.
Rifaximin's therapeutic spectrum: approved indications and experimental insights into emerging uses [0.03%]
利福昔明的治疗谱系：已批准的适应证及新用途实验研究见解
Irene Palenca,Silvia Basili Franzin,Marcella Pesce et al.
Irene Palenca et al.
The extensive erythrocyte-plasma partitioning of trametinib - implications for pharmacokinetic studies and therapeutic drug monitoring [0.03%]
曲马替尼的红细胞分布特性及其对药代动力学研究和治疗药物监测的影响
Bence János Chriszt,Zoltán Köllő,Orsolya Geda et al.
Bence János Chriszt et al.
Trimetazidine modulates angiogenesis, inflammation, and metabolism-related gene expression to promote diabetic foot ulcer healing: a transcriptomic analysis [0.03%]
曲美他嗪通过调节糖尿病足溃疡的血管生成、炎症和代谢相关基因表达来促进伤口愈合：转录组学分析
Dorian Dulcic,Lucija Dumancic,Andrea Crkvenac Gregorek et al.
Dorian Dulcic et al.
Background: Diabetic foot ulcers (DFUs) are a chronic complication of diabetes associated with impaired healing and tissue ischemia. Aim: ...
Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice [0.03%]
慢性 fasudil 治疗通过调节 GABAA 受体 γ2 亚基的表达产生类似苯二氮卓类药物的耐受性并损害小鼠的情境恐惧记忆
Teresa Dipol,Ornella Morsilli,Andrea Fortuna et al.
Teresa Dipol et al.
The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes [0.03%]
一种PERK抑制剂GSK26506414可引起斑马鱼发育缺陷与Wolcott-Rallison综合征表型一致
Liliana M Almeida,Leonor Pereira Lima,Nuno A S Oliveira et al.
Liliana M Almeida et al.
Naringenin and quercetin alter mouse rod phototransduction kinetics in a manner consistent with phosphodiesterase-6 inhibition [0.03%]
大鼠视杆细胞光转导动力学受大豆异黄酮和类黄酮的抑制作用的影响
Lorenzo Cangiano,Claudia Gargini,Sabrina Asteriti
Lorenzo Cangiano