Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures [0.03%]
亲吻肽-10调节人心脏成纤维细胞培养中的糖胺聚糖和角域素含量
Paulina Radwańska,Maciej Olkiewicz,Lucyna Piera et al.
Paulina Radwańska et al.
Background: Cardiac fibroblasts play a key role in extracellular matrix (ECM) remodelling through the synthesis of glycosaminoglycans and proteoglycans (PGs), such as decorin; however, the effects of kisspeptin-10 (KiSS-1...
Treatment-emergent psychiatric adverse events in patient-reported outcomes during ketamine use for major depressive disorder: a retrospective analysis [0.03%]
氯胺酮治疗难治性抑郁症患者出现的精神类不良事件的回顾性分析研究
Aleksander Kwaśny,Alina Wilkowska,Michał Pastuszak et al.
Aleksander Kwaśny et al.
Background: Treatment-resistant depression (TRD) poses a significant therapeutic challenge, with remission often unattainable. Recognition and detection of treatment-emergent adverse events (TEAEs) are essential, as these...
Clozapine levels in inpatients with schizophrenia are not a predictor of rehospitalization: a naturalistic retrospective study [0.03%]
住院精神病患者氯氮平血药浓度与再入院无关：一项自然主义的回顾性研究
Anna Mach,Przemysław Bieńkowski,Anna Wnorowska et al.
Anna Mach et al.
Background: Although therapeutic drug monitoring (TDM) is recommended for personalized clozapine (CLO) dose titration, there are no widely accepted international guidelines regarding routine TDM during long-term outpatien...
The impact of gadolinium doping on physicochemical properties and neuroprotective activity of polyacrylic acid conjugated cerium oxide nanoparticles - in vitro study of potential theranostics for neurodegenerative diseases [0.03%]
掺杂钆的交联聚丙烯酸包被的纳米铈氧化物的理化性质及其神经保护活性的体外研究-用于神经退行性疾病的诊疗一体化药物的潜在应用研究
Rugmani Meenambal,Tomasz Kruk,Piotr Warszyński et al.
Rugmani Meenambal et al.
Background: Cerium oxide nanoparticles (CeO NPs) are showing neuroprotective effects in various experimental models of neurodegeneration. Doping of nanoparticles with magnetic resonance imaging (MRI) contrast agents (e.g....
Recent advances in indole-thiazole hybrid scaffolds: synthesis, molecular hybridization, and pharmacological potential [0.03%]
吲哚-噻唑杂合支架的近期研究进展：合成、分子杂交和药理潜能
Doaa A Abdelrheem,Sally Mostafa Khadrawy,Mohamed A M Ali et al.
Doaa A Abdelrheem et al.
Indole-thiazole hybrids have attracted increasing interest in medicinal chemistry in recent years, combining the privileged indole nucleus with the thiazole ring within a single framework. The indole unit offers opportunities for π-π inte...
The novel third-generation antipsychotic drug brexpiprazole affects hepatic transcription factors, serum hormone levels, and cytochrome P450 enzymes after prolonged treatment: pharmacological significance [0.03%]
新型第三代抗精神病药物brexpiprazole对长期治疗后肝转录因子、血清激素水平及细胞色素P450酶的影响及药理学意义
Przemysław J Danek,Renata Pukło,Władysława A Daniel
Przemysław J Danek
Background: Brexpiprazole is a third-generation antipsychotic used for the treatment of schizophrenia or as an adjunctive drug for the treatment of affective and neurological disorders. The combined treatments with brexpi...
Unraveling the therapeutic potential of luteolin in renal pathology: a comprehensive pathway oriented approach [0.03%]
基于途径的全面方法探究染料木素在肾疾病治疗中的潜力
Lovedeep Singh,Anish Singh,Ayush Kattna et al.
Lovedeep Singh et al.
Kidney diseases, particularly chronic kidney disease (CKD), represent a significant global health challenge, affecting over 9.5% of the world's population. Both systemic inflammation and oxidative stress are strongly associated with the dev...
Zakia Sultana,Ashif Ahamed,Muddasarul Hoda et al.
Zakia Sultana et al.
Redox rewiring in glioblastoma: the thioredoxin system as a precision therapeutic target [0.03%]
胶质母细胞瘤中的氧化还原重构：硫氧还蛋白系统作为精准治疗靶点
Hilda Espinoza,Agustín Gómez-Barrientos,Francisco López-Godoy et al.
Hilda Espinoza et al.
The thioredoxin system, comprising thioredoxin (Trx) and thioredoxin reductase (TrxR), is a central regulator of cellular redox homeostasis and plays essential roles in normal brain physiology and redox signaling. In glioblastoma (GBM), thi...
A validated FACS-based protocol for the isolation of neuronal and non-neuronal cells from frozen adult brain, suitable for integrated gene and protein analysis [0.03%]
一种用于从冻存的成年脑组织中分离神经元和非神经元细胞的FACS实验方案，并可用于基因和蛋白分析
Magdalena Kolasa,Adam Roman,Przemysław Mielczarek et al.
Magdalena Kolasa et al.