Effects of curcumin on vascular smooth muscle cells: implications for health and disease [0.03%]
姜黄素对血管平滑肌细胞的影响：健康和疾病的含义
Majid Shohrati,Farshad Abedi,Mahdi Bagheri et al.
Majid Shohrati et al.
Vascular smooth muscle cells (SMCs) are pivotal in regulating vascular tone and integrity. Their dysregulation significantly contributes to the pathophysiology of cardiovascular ailments, including atherosclerosis, blood pressure, and vascu...
Novel receptor tyrosine kinase-targeted strategies to overcome resistance in oral squamous cell carcinoma [0.03%]
针对头颈鳞癌受体酪氨酸激酶靶向的新策略以克服耐药性问题
Shahryar Irannejadrankouhi,Hassan Mivehchi,Aisan Eskandari-Yaghbastlo et al.
Shahryar Irannejadrankouhi et al.
Treatment for oral squamous cell carcinoma (OSCC) has seen the rise of receptor tyrosine kinase inhibitors (RTKIs). However, their therapeutic effectiveness is severely limited by the emergence of resistance. Epidermal growth factor recepto...
Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models [0.03%]
纠正：化合物PZ-1262（Brexpiprazole的4-异喹啉磺胺类似物）在啮齿动物模型中产生潜在的抗抑郁，抗焦虑和改善认知的作用
Anna Partyka,Joanna Gołębiowska,Krzysztof Marciniec et al.
Anna Partyka et al.
Published Erratum
Pharmacological reports : PR. 2025 May 30. DOI:10.1007/s43440-025-00741-6 2025
Biomarkers associated with antidepressant response and illness severity in major depressive disorder: a pilot study [0.03%]
与抑郁症抗抑郁反应和疾病严重程度相关的生物标志物：一项初步研究
Massimiliano Buoli,Cecilia Maria Esposito,Alessandro Ceresa et al.
Massimiliano Buoli et al.
Background: Major Depressive Disorder (MDD) is a prevalent condition characterized by alterations in different biological systems including inflammatory and antioxidant pathways. Antidepressants seem to rebalance biologic...
Marizomib in the therapy of brain tumors-how far did we go and where do we stand? [0.03%]
马利佐米治疗脑肿瘤的研究进展如何？我们处在什么位置？
Magdalena Kusaczuk,Wiktoria Monika Piskorz,Julia Domasik
Magdalena Kusaczuk
Out of several types of tumors of the central nervous system (CNS), glioblastoma (GBM) represents one of the most frequent and malignant forms of brain neoplasms. To date, GBM holds very limited therapeutic options leaving patients with poo...
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia [0.03%]
HCRTR1/2基因变异与其他非遗传因素对异丙酚、右美托咪定和雷米芬太尼麻醉期间的觉醒转换和血流动力学稳定性联合影响的作用机制研究
Zhuoling Zheng,Faling Xue,Haini Wang et al.
Zhuoling Zheng et al.
Background: Propofol-remifentanil-dexmedetomidine-based total intravenous anesthesia is widely utilized in clinical practice. However, maintaining safety during the sleep-wake transition and ensuring hemodynamic stability...
Naltrexone dose-selectively modulates goal-directed behavior and the hypothalamic proteome in rats [0.03%]
纳曲酮剂量特异性地调节大鼠目标导向行为和下丘脑蛋白质组
Natalia Malikowska-Racia,Przemysław Mielczarek,Piotr Popik
Natalia Malikowska-Racia
Background: Naltrexone is an opioid receptor antagonist that can modulate reward processing in opposite directions depending on the dose. Whether naltrexone similarly affects motivation remains unexplored. This study inve...
Ocular microvascular changes in COVID-19: role of hypoxia, D-dimer, IL-6 and systemic treatment [0.03%]
COVID-19的眼底微血管改变：缺氧、D-二聚体、IL-6及全身治疗的作用
Magdalena Kal,Michał Brzdęk,Izabella Karska-Basta et al.
Magdalena Kal et al.
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with endothelial dysfunction, which may also compromise the microcirculation within ocular tissues. This prospective study e...
Rafał Krasowski,Katarzyna Kamińska,Katarzyna Głodek et al.
Rafał Krasowski et al.
Recent years have seen a search for more effective forms of asthma therapy, with one possible option being vitamin D supplementation. The main objective of this study was to present the current state of knowledge on the effect of vitamin D ...
Mechanisms and potential therapeutic strategies of withaferin A in breast cancer [0.03%]
Withaferin A在乳腺癌中的机制及其潜在治疗策略
Xin Chen,Xijun Ma,Xiaofei Hu et al.
Xin Chen et al.
Breast cancer (BC) is one of the most common malignant tumors in women worldwide, and its treatment faces numerous challenges. Despite the effectiveness of modern treatment methods such as surgery, radiotherapy, chemotherapy, and targeted t...