A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes [0.03%]
一种新的2-氧化吡咯烷衍生物(LN-53)有效诱导人表皮角质细胞中Nrf-2信号通路的激活
Basak Ezgi Sarac,Laura Nissim,Dilara Karaguzel et al.
Basak Ezgi Sarac et al.
Background: The skin is a pivotal organ that serves as a physical barrier, protecting the body from harmful substances such as pathogens, allergens, and other environmental irritants. Chronic inflammation in the skin, alo...
Exploring the pharmacological mechanisms and therapeutic implications of galangin against neurological disorders [0.03%]
探讨姜黄素的药理机制及其对神经疾病的治疗意义
Xueying Zhang,Guangcheng Zhong,Haike Wu
Xueying Zhang
Neurological disorders represent a leading cause of mortality and disability worldwide, encompassing a broad spectrum of prevalent conditions such as Alzheimer's disease, epilepsy, and stroke. In recent years, natural compounds have garnere...
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results [0.03%]
稳定期慢性阻塞性肺疾病患者的碘甲状腺氨酸脱碘酶的初步研究结果
Elżbieta Małujło-Balcerska,Anna Kumor-Kisielewska,Maria Gałecka et al.
Elżbieta Małujło-Balcerska et al.
Background: Different immune/inflammatory molecules play key roles in the development of inflammatory diseases, including chronic obstructive pulmonary disease (COPD). Thyroid hormones (THs) participate in immune/inflamma...
The application of telmisartan in central nervous system disorders [0.03%]
telmisartan在中枢神经系统疾病中的应用研究进展
Wei Quan,Shui-Xian Zhang,Xu-Yang Zhang et al.
Wei Quan et al.
Telmisartan, a well-established antihypertensive drug, has shown promising therapeutic potential for a variety of central nervous system (CNS) disorders. This review outlines the fundamental characteristics of telmisartan, focusing on its d...
Empiric and targeted antibiotic therapy for bloodstream infections in internal medicine patients in Poland: a three-year analysis in a single centre using the AWaRe classification [0.03%]
波兰内科患者血流感染的经验性和目标性抗生素治疗：单一中心三年分析及AWaRe分类法
Piotr Piekiełko,Dariusz A Hareza,Ewa Stawowczyk et al.
Piotr Piekiełko et al.
Background: Bloodstream infection (BSI), defined as bacteraemia accompanied by sepsis or septic shock, is a frequent cause of hospitalization in departments of internal medicine (DIM). This study aimed to characterize the...
The phenomenology of psilocybin's experience mediates subsequent persistent psychological effects independently of sex, previous experience, or setting [0.03%]
裸盖菇素的主观体验现象学独立于性别、过往经历或环境等因素介导其持续的心理效应
Tereza Klučková,Marek Nikolič,Filip Tylš et al.
Tereza Klučková et al.
Background: Recent studies intensively explore psilocybin's antidepressant potential, but variables like previous experience, repeated use, setting, and sex remain underexplored. This study examines acute and long-term ef...
Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats [0.03%]
大麻二酚青少年期给药产生抗抑郁作用而不影响远期认知功能
Laura Gálvez-Melero,Itziar Beruete-Fresnillo,Sandra Ledesma-Corvi et al.
Laura Gálvez-Melero et al.
Background: Recent preclinical studies have shown sex-dependent antidepressant-like responses of cannabidiol in adolescence, which were dependent on biological sex, early-life stress, and dose. In particular, cannabidiol ...
Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges [0.03%]
炎症性肺疾病：最新进展与挑战的临床和科学综述
Ahmed A Katamesh,Khaled Almansour,Shimaa M Hassoun et al.
Ahmed A Katamesh et al.
Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions ar...
Residence time in drug discovery: current insights and future perspectives [0.03%]
药物发现中的停留时间：当前见解与未来展望
Szymon K Kordylewski,Ryszard Bugno,Sabina Podlewska
Szymon K Kordylewski
The temporal stability of ligand-receptor complexes is increasingly acknowledged as a critical factor in drug discovery, influencing both efficacy and pharmacodynamics. Although the relationship between the duration of compound action and c...
Unveiling hidden risks: pharmacogenetic insights from a cross-sectional study of statin therapy in the Indian population [0.03%]
揭开隐藏的风险：印度人群他汀治疗的药代基因组学横断面研究的新见解
Shaik Mohammad Naushad,Palani Kumar Palanichamy,Jagadeesh Babu Sreemanthula et al.
Shaik Mohammad Naushad et al.
Background: Statin usage has increased significantly in India due to the very high incidence of dyslipidemia, however, approximately 18% of the population is at risk for statin-induced myopathy. Hence, we conducted a popu...