Real‑world safety and efficacy of biological agents in inflammatory bowel disease: a one-year post-marketing pharmacovigilance observational study in the Calabria region [0.03%]
川碱地区炎症性肠病生物制剂真实世界安全性和有效性的post-marketing药物流行病学研究一年结果
Antonio Fabiano,Caterina De Sarro,Domenico Frajia et al.
Antonio Fabiano et al.
Background: The use of immune-modifying biological agents has markedly changed the clinical course and the management of inflammatory bowel diseases (IBDs). Active post-marketing surveillance programs are essential for th...
Saikosaponin A, a bioactive compound from Bupleuri radix, protects dopaminergic neurons and correlates with NURR1 expression in 6-hydroxydopamine-injected hemi-parkinsonian mouse model [0.03%]
防风草根中生物活性化合物飞燕草素A通过调节NURR1表达保护纹状体多巴胺神经元
Eugene Huh,Yujin Choi,Jin Hee Kim et al.
Eugene Huh et al.
Background: Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss, and current treatments are limited by their inability to prevent neurodegeneration. NURR1, a crucial transcription factor fo...
Pretreatment with alendronate augments lipid A-induced IFN-β production via upregulation of cGAS expression [0.03%]
阿仑膦酸钠通过上调cGAS表达增强脂多糖诱导的IFN-β产生
Satoru Watanabe,Yusuke Kiyoura,Riyoko Tamai
Satoru Watanabe
Background: Alendronate (ALN), a nitrogen-containing bisphosphonate (NBP), augments proinflammatory cytokine production by mouse macrophage-like cells incubated with ligands of Toll-like receptor (TLR) 2 and TLR4. The pre...
Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells [0.03%]
Hericii Erinaceus et Lucidum Ganoderma Metabolitum in Neuronem HT-22 Cellularibus AhR Activationi Impactu
Anna Tabęcka-Łonczyńska,Bartosz Skóra,Dominika Szlachcikowska et al.
Anna Tabęcka-Łonczyńska et al.
Background: The proper functioning of the nervous system determines the homeostasis of the entire body. There are many known approaches designed to positively stimulate the functions of the central nervous system by apply...
The influence of morphine treatment on the opioid propeptide gene expression in the forebrain of two inbred mouse strains with different sensitivity to opioids [0.03%]
吗啡处理对两种不同阿片敏感性近交系小鼠大脑阿黑皮素原基因表达的影响
Barbara Ziółkowska,Agnieszka Gieryk,Ryszard Przewłocki
Barbara Ziółkowska
Background: C57BL/6 and DBA/2 mouse strains differ markedly in behavioral responses to acute and chronic morphine administration. Some of these disparities might be underlain by and/or correlated with different expression...
Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder [0.03%]
GRIN2B和NTRK2基因多态性与双相障碍发病机制及伐普肽和锂治疗反应的关系研究
Beatriz Camarena,Marco Antonio Sanabrais-Jiménez,Carlo Esteban Sotelo-Ramírez et al.
Beatriz Camarena et al.
Background: The pharmacological maintenance treatment for bipolar disorder patients depends on mood stabilizers such as lithium and valproate. An association between GRIN2B and NTRK2 gene polymorphisms and treatment respo...
Deciphering enemy tactics - the narrow path to an optimal anti-cancer strategy targeting the Warburg effect [0.03%]
破解敌军战术——针对瓦尔堡效应的精准抗癌策略之路
Kinga A Kocemba-Pilarczyk,Barbara Ostrowska,Sonia E Trojan et al.
Kinga A Kocemba-Pilarczyk et al.
Metabolic changes in cancer cells are crucial for maintaining their high growth and proliferation rate. As a result, many tumors are characterized by high glucose consumption and intensified aerobic glycolysis, a phenomenon known as the War...
Antinociceptive effects of intrathecal neuropeptide B/W receptor 1 agonists in mouse acute nociception, peripheral neuropathy, and inflammatory pain models [0.03%]
神经肽B/W受体1激动剂对小鼠急性痛觉、外周神经病理性疼痛和炎症性疼痛模型的镇痛作用
Yuma T Ortiz,Thuy Nguyen,Jenny L Wilkerson
Yuma T Ortiz
Background: The neuropeptide B/W receptor 1 (NPBWR1) system, including its two endogenous ligands, Neuropeptides B and W (NPB and NPW), has garnered interest as a potential target to develop novel analgesics. Behavioral s...
The sertraline metabolite, desmethylsertraline, may be implicated in adverse outcomes reported after gestational sertraline use: insights from a study in zebrafish [0.03%]
舍曲林代谢产物去甲基舍曲林可能与妊娠期使用舍曲林的不良结局有关：斑马鱼研究中的启示
Cassius M Phogole,Lesha Pretorius,Tracy Kellermann et al.
Cassius M Phogole et al.
Targeting TRPC6 in podocytopathies: Why clinical translation remains a challenge? [0.03%]
靶向治疗肾小球系膜病中的TRPC6蛋白：为何临床转化仍面临挑战？
Chirag A Patel,Sudhirkumar Patel,Sandip Patel et al.
Chirag A Patel et al.
Podocytopathies, driven by injury to glomerular podocytes, are a major cause of proteinuric kidney diseases like focal segmental glomerulosclerosis (FSGS) and diabetic kidney disease (DKD). The transient receptor potential canonical 6 (TRPC...