MMP-9 and MMP-2 regulation in patients undergoing non-oncological and non-vascular elective surgery independent of the use of propofol or sevoflurane [0.03%]
丙泊酚或七氟醚的使用对非血管及非肿瘤择期手术患者中基质金属蛋白酶-9和基质金属蛋白酶-2调节的影响独立性研究
Michał Kowalczyk,Małgorzata Guz,Estera Okoń et al.
Michał Kowalczyk et al.
Background: There is debate regarding whether inhaled sevoflurane or intravenous propofol used during anesthesia achieves the best outcome. Propofol has been shown to affect expression of matrix metalloproteinases (MMPs)....
Observational Study
Pharmacological reports : PR. 2019 Jun;71(3):528-534. DOI:10.1016/j.pharep.2019.02.009 2019
In vitro evidence that endothelium-dependent vasodilatation induced by clozapine is mediated by an ATP-sensitive potassium channel [0.03%]
氯丙嗪诱导的依赖内皮的血管舒张作用由ATP敏感型钾通道介导：体外证据
Luiza Silva Mateus,Agnes Afrodite S Albuquerque,Andrea Carla Celotto et al.
Luiza Silva Mateus et al.
Background: There is a definite association between antipsychotic drugs and arterial hypertension. However, endothelium functions are scarcely considered. This investigation was carried out to study the mechanisms involve...
Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma [0.03%]
西地那非和他达拉非对支气管哮喘动物模型炎症、氧化应激及硝化应激的抑制作用
Vijaya Laxmi,Rachna Gupta,Swapan K Bhattacharya et al.
Vijaya Laxmi et al.
Background: Cyclic neucleotides are involved in many cellular functions including smooth muscle relaxation, inflammation, and signal transduction. Sildenafil and tadalafil are phosphodiesterase-5 (PDE-5) inhibitors which ...
Copper nanoparticles modify the blood plasma antioxidant status and modulate the vascular mechanisms with nitric oxide and prostanoids involved in Wistar rats [0.03%]
铜纳米粒子可改变Wistar大鼠血浆抗氧化状态，并通过参与血管作用的硝酸盐和普拉司托oids进行调节
Michał Majewski,Katarzyna Ognik,Jerzy Juśkiewicz
Michał Majewski
Background: We aimed to analyze whether a diet supplemented with a standard dose of copper (Cu) in the form of nanoparticles, as an alternative to carbonate, exerts beneficial effects within the vasculature and improves t...
What is the combined effect of intense intermittent exercise and Ginkgo biloba plant on the brain neurotrophic factors levels, and learning and memory in young rats? [0.03%]
高强度间歇运动联合银杏叶提取物对青年大鼠脑源性神经营养因子影响及其与学习记忆的关系研究
Masoumeh Sadeghinejad,Zahra Soltani,Mohammad Esmaeil Afzalpour et al.
Masoumeh Sadeghinejad et al.
Background: The present study was conducted to investigate the effect of intense intermittent exercise and Ginkgo biloba on the hippocampal levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and ...
Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs [0.03%]
第三代抗癫痫药物致畸潜能：现状与研究需求
K P Singh,Niharika Verma
K P Singh
The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the inter...
Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles [0.03%]
基质金属蛋白酶抑制剂可阻止单核细胞/巨噬细胞微颗粒的释放及其蛋白水解活性
Stefano Fogli,Tommaso Neri,Elisa Nuti et al.
Stefano Fogli et al.
Background: The role of monocyte/macrophage-derived microparticles (MPs) in the pathophysiology of cancer and chronic inflammatory diseases has been reported; nevertheless, the mechanism underlying microparticles release ...
Verapamil prevents the effect of calcium-sensing receptor activation on the blood glucose and insulin levels in rats [0.03%]
维拉帕米可防止钙敏感受体激活对大鼠血糖和胰岛素水平的影响
Anna Szczoczarz,Aleksandra Marchwińska,Aleksandra Dyś et al.
Anna Szczoczarz et al.
Background: The Ca2+ triggered insulin exocytosis in β cells of the pancreatic islets may be the result of Ca2+ influx through L-type voltage dependent calcium channels (VDCC) localized in the plasma membrane, as well as...
Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis [0.03%]
Pixantrone、依托泊苷、苯达莫司汀和利妥昔单抗（P[R]EBEN）作为挽救方案治疗复发/难治性侵袭性非霍奇金淋巴瘤的疗效——波兰淋巴瘤研究小组的真实世界分析
Monika Długosz-Danecka,Iwona Hus,Bartosz Puła et al.
Monika Długosz-Danecka et al.
Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autol...
Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice [0.03%]
心得安对鼠最大电休克阈值影响及与抗惊厥药作用关系的研究
Mariusz Świąder,Izabela Zakrocka,Katarzyna Świąder et al.
Mariusz Świąder et al.
Background: β2-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic ...