Hypocholesterolemic agents and the gut microbiota: a review of interactions and modulatory activity [0.03%]
降胆固醇药物与肠道微生物组：相互作用及调节活性综述
Manuel Mântua E Garcia,Virginie Xavier,Ricardo C Calhelha et al.
Manuel Mântua E Garcia et al.
Hypercholesterolemia is a major risk factor that contributes to the development and/or aggravation of cardiovascular diseases. High cholesterol levels are frequently managed with hypocholesterolemic agents, either synthetic or natural. Beyo...
Italian regional data and oropharyngeal adverse events to drugs and vaccines: insights from a 3-year spontaneous reporting (2022-2024) [0.03%]
意大利区域药品和疫苗不良事件报告数据：一项为期三年的自发报告研究（2022-2024）对药物和疫苗口腔和咽部不良事件的见解
Liberata Sportiello,Mario Gaio,Alessia Zinzi et al.
Liberata Sportiello et al.
Background: Oropharyngeal adverse events (O-AEs) represent a potential safety concern associated with several drugs and/or vaccines. Although often underestimated, these events may provide valuable insights into a patient...
AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation [0.03%]
抑郁症中的AMPAR调节：从突触可塑性的分子机制到临床转化研究
Wojciech Ziemichód,Natalia Kajka,Klaudia Kister et al.
Wojciech Ziemichód et al.
The glutamatergic system, particularly N-methyl-D-aspartate (NMDA) receptors, has long been a significant focus of research into new strategies for treating depression, and the clinical success of ketamine, an NMDA receptor antagonist, has ...
A discovery-based proteomic approach of epidermal growth factor and growth hormone-releasing peptide-6 in a model of acute ischemic stroke [0.03%]
表皮生长因子和生长激素释放肽-6在急性缺血性脑卒中模型中的发现及蛋白质组学研究
Arielis Rodríguez-Ulloa,Nelvys Subirós-Martínez,Luis Javier González et al.
Arielis Rodríguez-Ulloa et al.
Background: Combined therapy with epidermal growth factor (EGF) and growth hormone-releasing peptide 6 (GHRP6) has demonstrated neuroprotective effects in models of global and focal brain ischemia. Clinical studies in isc...
In vitro inhibition of Escherichia coli β-glucuronidase by aripiprazole [0.03%]
阿立哌唑对体外培养的大肠杆菌β-葡萄糖醛酸酶的抑制作用
Kohsuke Sugiyama,Kensuke Sato,Hanako Aoki et al.
Kohsuke Sugiyama et al.
Background: Gut microbial β-glucuronidase (GUS) regulates the deconjugation of glucuronidated compounds, thereby influencing the enterohepatic circulation of xenobiotics and endogenous metabolites. Although many orally a...
Evaluation of the safety profile of glucagon-like peptide-1 receptor agonists: a focus on thyroid cancer-related adverse events by using the European pharmacovigilance database [0.03%]
利用欧洲药物警戒数据库评估GLP-1受体激动剂的安全性：关注与甲状腺癌相关的不良事件
Antonietta Anatriello,Valerio Liguori,Ciro Pentella et al.
Antonietta Anatriello et al.
Introduction: The therapeutic landscape for the treatment of type 2 diabetes mellitus (T2DM) has greatly evolved with the introduction of glucagon-like peptide-1 receptor agonists (GLP-1 RAs); however, concerns regarding ...
Targeting epigenetic and DNA topology mechanisms: histone deacetylases and topoisomerase inhibitors in combination and dual inhibition approaches [0.03%]
表观遗传和DNA拓扑机制的靶向：组蛋白去乙酰酶和拓扑异构酶抑制剂联合用药及双重抑制策略
Yashaswini Reddy,Vyasraj G Bhat,Mukirala Vasanth Kumar et al.
Yashaswini Reddy et al.
Cancer is a complex and multifactorial disease, often characterized by disruptions in key cellular processes such as gene expression and DNA topology. Histone deacetylases (HDACs) and topoisomerases (Topo) are two major molecular targets fo...
Selective non-nuclear estrogen receptor activation with PaPE-1 evokes neuroprotection involving mTOR/MEK in an in vitro model of hypoxic/ischemic injury [0.03%]
选择性非雌激素受体激活剂PaPE-1通过mTOR/MEK在缺血缺氧模型中产生神经保护作用
Andrzej Łach,Bernadeta A Pietrzak-Wawrzyńska,Karolina Przepiórska-Drońska et al.
Andrzej Łach et al.
Background: Hypoxic/ischemic brain injuries, including ischemic stroke and perinatal asphyxia, remain major causes of mortality and long-term neurological disability, establishing a demand for therapeutic strategies suita...
Association between elemental concentrations and chemotherapy-related acute adverse events in patients with nasopharyngeal carcinoma [0.03%]
鼻咽癌患者微量元素浓度与化疗相关急性不良事件的关联性研究
Xi Chen,Tian-Rui Gao,Li-Xia Peng et al.
Xi Chen et al.
Background: While environmental exposure to toxic elements, such as cadmium (Cd) and chromium (Cr), is known to impair general organ function, its specific impact on patients' tolerance to platinum (Pt)-based chemotherapy...
Therapeutic potential of combining mirogabalin with antidepressants in relieving hypersensitivity: evidence from a mouse model of neuropathic pain [0.03%]
米罗呱林与抗抑郁药联合治疗神经病理性疼痛小鼠模型高敏症状的潜力：证据表明存在疗效加成效应
Renata Zajączkowska,Agata Ciechanowska,Katarzyna Pawlik et al.
Renata Zajączkowska et al.
Background: Neuropathic pain remains a significant clinical problem that necessitates the development of more effective treatment options. Compared with commonly used clinical drugs, such as gabapentin and pregabalin, mir...