The Prevalence and Management of Systemic Amyloidosis in Western Countries [0.03%]
西方国家系统性淀粉样变流行病学与治疗概述
Hans L A Nienhuis,Johan Bijzet,Bouke P C Hazenberg
Hans L A Nienhuis
Background: Amyloidosis has been a mystery for centuries, but research of the last decennia has clarified many of the secrets of this group of diseases. A protein-based classification of amyloidosis helps to understand pr...
The Clinical Presentation and Management of Systemic Light-Chain Amyloidosis in China [0.03%]
中国全身轻链型淀粉样变性的临床表现和治疗体验
Xiang-Hua Huang,Zhi-Hong Liu
Xiang-Hua Huang
Background: Amyloidosis includes a group of diseases characterized by the extracellular deposition of various fibrillary proteins that can autoaggregate in a highly abnormal fibrillary conformation. The amyloid precursor ...
SIRT1 and Kidney Function [0.03%]
SIRT1与肾功能
Yi Guan,Chuan-Ming Hao
Yi Guan
Background: SIRT1 is a nicotinamide adenine dinucleotide-dependent deacetylase belonging to the class III histone deacetylases. Abundantly expressed in the kidney, especially in the renal medulla, SIRT1 is closely involve...
Punit Yadav,Mark Cook,Paul Cockwell
Punit Yadav
Background: Renal impairment (RI) is a common complication of multiple myeloma (MM). Around 50% of patients with MM have RI at presentation, and up to 5% require dialysis treatment. Severe acute kidney injury (AKI) as a c...
The Prevalence and Management of Multiple Myeloma-Induced Kidney Disease in China [0.03%]
中国多发性骨髓瘤致肾脏疾病患病率与治疗现状
Hao Shi,Zijin Chen,Jingyuan Xie et al.
Hao Shi et al.
Background: Multiple myeloma (MM) is a clonal B-cell malignancy of the bone marrow. Renal impairment is a common complication of MM. So far, there is no systematic overview of MM-induced kidney disease in China. ...
The Prevalence and Management of Pauci-Immune Glomerulonephritis and Vasculitis in Western Countries [0.03%]
西方国家寡免疫性肾小球肾炎和血管炎的流行病学及治疗概述
Sophia Lionaki,John N Boletis
Sophia Lionaki
Background: Pauci-immune glomerulonephritis is the most common cause of aggressive glomerulonephritis and occurs as a renal-limited disease or as a component of systemic necrotizing small-vessel vasculitis. It is characte...
The Prevalence and Management of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in China [0.03%]
中国抗中性粒细胞胞浆抗体相关性血管炎的患病率及诊疗状况
Zhi-Ying Li,Tian-Tian Ma,Min Chen et al.
Zhi-Ying Li et al.
Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA). Myeloperoxidase (MPO) and p...
Hong Xiao,Peiqi Hu,Ronald J Falk et al.
Hong Xiao et al.
Background: Antineutrophil cytoplasmic autoantibodies (ANCA) are associated with a spectrum of necrotizing vasculitis including granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with ...
Humaira Masood,Ruochen Che,Aihua Zhang
Humaira Masood
Background: The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of in...
Michael V Rocco
Michael V Rocco
Background: Chronic hemodialysis (HD) in the 1960s encompassed a wide variety of prescriptions from twice weekly to five times per week HD. Over time, HD prescriptions in the West became standardized at three times per we...