Genetic Susceptibility to Nephrolithiasis: A Genome-Phenome Approach with Polygenic Risk Score Analysis [0.03%]
高钙尿症遗传易感性：多基因风险评分分析下的基因型与表型研究
Chun-Yi Chen,Sunyeop Lee,Chi-Maw Lin et al.
Chun-Yi Chen et al.
Introduction: Kidney stone disease (KSD) is multifactorial, and the genetic basis is poorly understood among the East Asian population. This study aims to elucidate comprehensive genetic factors associated with KSD. ...
Clinicopathological Characteristics and Prognostic Implications of Periodic Acid-Schiff-Positive Amyloid Deposits in Renal AL Amyloidosis [0.03%]
刚果红阴性淀粉样变在AL型肾小球淀粉样变中的临床病理特征及预后意义
Yueyue Zhu,Ying Yao,Kai Chen et al.
Yueyue Zhu et al.
Introduction: It has been recognized that periodic acid-Schiff (PAS) staining of amyloid deposits is typically weak or negative in the majority of AL amyloidosis. However, a subset of patients exhibits PAS-positive deposi...
Genetic Insights into Persistent Hypouricemia in Adults: Novel Findings from an Adult Nephrogenetic Clinic [0.03%]
成人持续性低尿酸血症的基因见解：来自成人肾源性诊所的新发现
Ahmet Burak Dirim,Ilknur Suer,Tugba Kalaycı et al.
Ahmet Burak Dirim et al.
Introduction: Hypouricemia is an often-overlooked condition. Isolated persistent hypouricemia is rare and may be associated with uncommon genetic disorders, such as familial renal hypouricemia or xanthinuria. ...
Enhanced miR-214 in Vascular Endothelial Cells Retards Renal Inflammation and Glomerular Sclerosis in Five-Sixths Nephrectomy Mice [0.03%]
血管内皮细胞中增强的miR-214可延缓五六肾切除小鼠的肾脏炎症和系膜增生
Lingxiao Tan,Xinwen Fan,Xiaolu Zhang et al.
Lingxiao Tan et al.
Introduction: Vascular endothelial injury is a critical driver of renal dysfunction and glomerulosclerosis in chronic kidney disease (CKD). While endothelial damage-induced inflammation contributes to sclerosis, the under...
Lipocalin-2 Emerges as a Core Pathogenic Mediator and Biomarker in Autosomal Dominant Tubulointerstitial Kidney Disease-UMOD via Transcriptomic Profiling [0.03%]
转录组分析发现lipocalin-2在常染色体显性遗传的 tubulointerstitial kidney disease-UMOD 中作为重要致病介质和生物标志物发挥作用
Ruilian You,Zhi-Ying Liu,Meng-Shi Li et al.
Ruilian You et al.
Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a group of inherited renal disorders characterized by progressive decline in kidney function, with UMOD being the most frequently mutated gene....
Exploring the Value of Functional Magnetic Resonance Imaging in Assessing Subclinical Rejection in Kidney Transplantation [0.03%]
功能磁共振在肾脏移植术后隐匿性排斥反应中价值的探索研究
Lilin Liu,Ziyang Liu,Fangfang Yin et al.
Lilin Liu et al.
Introduction: Functional magnetic resonance imaging (fMRI) is a promising method to assess kidney injury noninvasively. This study aimed to explore the value of fMRI in assessing subclinical rejection and provide potentia...
Risk Factors for Pulmonary Hypertension and Survival in Hemodialysis Patients: Are We Overlooking Serum Magnesium? [0.03%]
血镁被忽视了吗——血液透析患者肺动脉高压的危险因素及影响生存的因素
Jinhui Song,Xueqin Bian,Bing Zhuang et al.
Jinhui Song et al.
Introduction: Pulmonary hypertension (PH) is a major complication in patients undergoing maintenance hemodialysis (MHD), significantly elevating the risk of cardiovascular events and mortality and severely impairing quali...
Clinicopathological Features and Outcomes of Nondiabetic Renal Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study [0.03%]
2型糖尿病患者非糖尿病肾病的临床病理特征及预后：回顾性队列研究
Ting Zhou,Qiye Liu,Ze Li et al.
Ting Zhou et al.
Introduction: This study evaluated the clinicopathological profiles and prognostic trajectories of nondiabetic renal disease (NDRD) subtypes coexisting with type 2 diabetes mellitus (T2D). ...
Interstitial Fibrosis and Tubular Atrophy as a Predictor of Renal Outcomes in Patients with Malignant Hypertension-Related Thrombotic Microangiopathy: A Multicentric Cohort Study [0.03%]
恶性高血压相关血栓性微血管病患者肾间质纤维化和小管萎缩的预后预测价值：一项多中心队列研究
Xianghui Chen,Zefang Dai,Zhong Zhong et al.
Xianghui Chen et al.
Introduction: Interstitial fibrosis and tubular atrophy (IFTA) are common pathological findings in patients with malignant hypertension (mHTN)-related thrombotic microangiopathy (TMA), but their predictive value for renal...
Inhibition of Plk1 Attenuates Downregulation of Water and Sodium Transporters in Obstructive Nephropathy [0.03%]
PLK1抑制作用可减轻阻塞性肾病中的水和钠转运体下调现象
Mengyu Zhou,Weidong Cao,Xiuli Lin et al.
Mengyu Zhou et al.
Introduction: Obstructive nephropathy is frequently associated with downregulation of key renal water and sodium transporters, resulting in impaired urinary concentration and disrupted fluid balance. The present study aim...