The Kidney in Bardet-Biedl Syndrome: Possible Pathogenesis of Urine Concentrating Defect [0.03%]
巴德-毕迭综合征的肾脏改变及尿浓缩障碍的发生机制探讨
Miriam Zacchia,Valentina Di Iorio,Francesco Trepiccione et al.
Miriam Zacchia et al.
Background: The ciliopathies are a growing number of disorders caused by mutations in genes involved in the function of the primary cilium. Bardet-Biedl syndrome (BBS) belongs to this group of disorders. In this setting, ...
Olivia Boyer,Guillaume Dorval,Aude Servais
Olivia Boyer
Idiopathic nephrotic syndrome may have two underlying mechanisms: either (1) an alteration of the immune system resulting in the production of a putative circulating factor of glomerular permeability; or (2) mutations in the structural gene...
Rare Renal Diseases Can Be Used as Tools to Investigate Common Kidney Disorders [0.03%]
罕见肾脏病可以作为探究常见肾病的工具
Mariadelina Simeoni,Sara Damiano,Giovanna Capolongo et al.
Mariadelina Simeoni et al.
Background: The prevention and slowing of chronic kidney disease still represent major challenges in nephrology. To this end, a major contribution may come from the extensive knowledge on the molecular pathways involved i...
Csaba P Kovesdy,Susan L Furth,Carmine Zoccali;World Kidney Day Steering Committee
Csaba P Kovesdy
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney dise...
Sodium-Glucose Cotransporter 2 Inhibitors with Renoprotective Effects [0.03%]
具有肾保护作用的钠-葡萄糖共转运蛋白2抑制剂
Bancha Satirapoj
Bancha Satirapoj
Background: Diabetes is the leading cause of end-stage renal disease (ESRD) and accounts for 40-50% of patients requiring renal replacement therapy. The main pathophysiology of diabetic nephropathy comprises glucose-depen...
Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease [0.03%]
慢性肾脏病与心血管疾病中的Klotho/FGF23轴
Xiang Lu,Ming Chang Hu
Xiang Lu
Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. F...
Hope for CKD-MBD Patients: New Diagnostic Approaches for Better Treatment of CKD-MBD [0.03%]
慢性肾脏病矿物质骨代谢异常的诊疗新进展给患者带来希望
Berthold Hocher,Andreas Pasch
Berthold Hocher
Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) patients have a huge morbidity and mortality. Only relatively minor progress in therapeutic strategies has been made in the past decades. This is at l...
Masafumi Fukagawa,Hirotaka Komaba
Masafumi Fukagawa
Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the most common complications in patients with CKD. As CKD-MBD is a systemic syndrome, prevention and management should be aimed at achievin...
Advances in Understanding and Management of Residual Renal Function in Patients with Chronic Kidney Disease [0.03%]
慢性肾脏病患者残余肾功能的研究进展及管理
Xin Liu,Chunsun Dai
Xin Liu
Background: Residual renal function (RRF), defined as the ability of native kidneys to eliminate water and uremic toxins, is closely correlated with mortality and morbidity rates among patients receiving either peritoneal...
Julian L Seifter,Hsin-Yun Chang
Julian L Seifter
Background: Disorders of acid-base involve the complex interplay of many organ systems including brain, lungs, kidney, and liver. Compensations for acid-base disturbances within the brain are more complete, while limitati...