Ablation of FGFR2 in Fibroblasts Ameliorates Kidney Fibrosis after Ischemia/Reperfusion Injury in Mice [0.03%]
小鼠缺血再灌注性肾纤维化时成纤维细胞FGFR2的消融缓解了肾纤维化的恶化
Zhuo Xu,Chunsun Dai
Zhuo Xu
Background: Fibroblast growth factors (FGFs) are heparin-binding proteins involved in a variety of biological processes. However, the role and mechanisms of FGF/FGFR2 signaling in fibroblast activation and kidney fibrosis...
Review of the Diagnostic Evaluation of Normal Anion Gap Metabolic Acidosis [0.03%]
正常阴离子间隙代谢性酸中毒诊断评估的再评价
Kenrick Berend
Kenrick Berend
Background: Normal anion gap metabolic acidosis is a common but often misdiagnosed clinical condition associated with diarrhea and renal tubular acidosis (RTA). Early identification of RTA remains challenging for inexperi...
Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update [0.03%]
慢性肾脏病患者和非慢性肾脏病患者的酸碱及电解质紊乱：最新研究进展
Tsering Dhondup,Qi Qian
Tsering Dhondup
Kidneys play a pivotal role in the maintenance and regulation of acid-base and electrolyte homeostasis, which is the prerequisite for numerous metabolic processes and organ functions in the human body. Chronic kidney diseases compromise the...
Definition, Management, and Outcomes of Acute Kidney Injury: An International Survey of Nephrologists [0.03%]
急性肾损伤的定义、管理和预后：国际肾脏病学家调查
Umar Farooq,Aaron Tober,Vernon Chinchilli et al.
Umar Farooq et al.
Background: Acute kidney injury (AKI) is a complex disease burdened by uncertainties of definition, management strategies, and prognosis. This study explores the relationship between demographic characteristics of nephrol...
Federica Petrillo,Anna Iervolino,Miriam Zacchia et al.
Federica Petrillo et al.
Background: MicroRNAs (miRNAs) are a family of short noncoding RNAs that play important roles in posttranscriptional gene regulation. miRNAs inhibit target gene expression by blocking protein translation or by inducing mR...
Doloretta Piras,Magdalena Zoledziewska,Francesco Cucca et al.
Doloretta Piras et al.
In recent years, the very high worldwide prevalence of chronic kidney disease (CKD) has led some authors to talk of an "epidemic." The progression of CKD varies considerably among individuals despite similar aetiologies, optimal blood press...
Francesco Trepiccione,Federica Prosperi,Luigi Regenburgh de la Motte et al.
Francesco Trepiccione et al.
Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of the urinary acidification process in the distal nephron. Complete or incomplete metabolic acidosis coupled with inappropriately alkalin...
Heng Li,Shiren Sun,Jianghua Chen et al.
Heng Li et al.
Background: Magnesium (Mg2+), the second most abundant cation in the cell, is woven into a multitude of cellular functions. Dysmagnesemia is associated with multiple diseases and, when severe, can be life-threatening. ...
Urinary Mitochondrial DNA Level as a Biomarker of Acute Kidney Injury Severity [0.03%]
线粒体DNA尿检水平作为急性肾损伤严重程度的生物标志物
Phoebe Wing-Lam Ho,Wing-Fai Pang,Cathy Choi-Wan Luk et al.
Phoebe Wing-Lam Ho et al.
Background: Mitochondrial dysfunction contributes to the pathogenesis of acute kidney injury (AKI). The urinary mitochondrial DNA (mtDNA) level was previously shown to predict renal function recovery in AKI following card...
Integration of Proteomics and Metabolomics in Exploring Genetic and Rare Metabolic Diseases [0.03%]
整合蛋白质组学和代谢组学以探索遗传性和罕见的代谢性疾病
Michele Costanzo,Miriam Zacchia,Giuliana Bruno et al.
Michele Costanzo et al.
Background: Inherited metabolic disorders or inborn errors of metabolism are caused by deficiency of enzymatic activities in the catabolism of amino acids, carbohydrates, or lipids. These disorders include aminoacidopathi...