Neurofilament light chain proteins are a sensitive biomarker of neuronal damage in cirrhotic patients with hepatic encephalopathy [0.03%]
神经丝轻链蛋白是肝硬化伴肝性脑病患者神经元损伤的敏感生物标志物
Clelia Asero,Francesca Polito,Maria Stella Franzé et al.
Clelia Asero et al.
Background and aims: Hepatic encephalopathy (HE) is a severe complication of liver cirrhosis. Although traditionally considered reversible, growing evidence suggests that HE episodes may lead to persistent neuronal damage...
Integrated bioinformatics and mendelian randomization reveal a six-gene diagnostic signature and key role of CYP26B1 in sarcopenia [0.03%]
整合生物信息学和孟德尔随机化揭示了 sarcopenia 的六基因诊断标志物以及 CYP26B1 基因的关键作用
Yaoqi Wu,Xiaoqing Cai,Shiwen Fan et al.
Yaoqi Wu et al.
Background: The pathogenesis of sarcopenia involves complex molecular mechanisms, and treatment remains challenging, with a lack of reliable diagnostic biomarkers. The objective of this study is to identify biomarkers tha...
Cell-free mitochondrial DNA (cf-mtDNA) in human body fluids: molecular characteristics, release mechanisms, and clinical translation-an updated review [0.03%]
人体液体中的细胞外线粒体DNA（cf-mtDNA）：分子特征、释放机制及其临床转化-综述更新版
Yu Liu,Xixiang Ma,Qingmei Guan et al.
Yu Liu et al.
Since its discovery, cell-free mitochondrial DNA (cf-mtDNA) has emerged as a promising non-invasive molecular marker for disease diagnosis and prognosis. However, the biological origins of cf-mtDNA remain incompletely understood, which limi...
Multi-target neuroprotection of carbon dots derived from Crinis Carbonisatus in multiple acute epilepsy model [0.03%]
Crinis碳点衍生的碳点在多种急性癫痫模型中的多靶点神经保护作用
Kai Cheng,Jie Hu,Xiaoke Wang et al.
Kai Cheng et al.
Background: Epilepsy remains a prevalent neurological disorder characterized by spontaneous, recurrent seizures. Despite available treatments, there is a critical lack of safe and effective strategies for long-term manage...
Uncovering distinct clinical phenotypes in disseminated intravascular coagulation through machine learning-enabled cluster analysis [0.03%]
通过机器学习驱动的聚类分析在弥漫性血管内凝血中发现不同的临床表型
Qingbo Zeng,Junjie Zeng,Qingwei Lin et al.
Qingbo Zeng et al.
Background: Disseminated intravascular coagulation (DIC) is a critical condition encountered in the intensive care unit (ICU), characterized by multiple etiologies and variable outcomes. Distinguishing between DIC phenoty...
Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma [0.03%]
识别肝细胞癌中与焦亡相关的长链非编码RNA以预测预后和免疫调节作用
Wenjie Zhang,Yinjie Wang,Qiang Meng et al.
Wenjie Zhang et al.
Background: Immunotherapy is often effective for treating hepatocellular carcinoma (HCC) and is widely used clinically, with variable effectiveness among individuals. ...
Identification of core genes and transcription factors related to metabolic reprogramming in atherosclerosis: a multi-omics analysis and experimental validation approach [0.03%]
动脉粥样硬化代谢重编程相关核心基因和转录因子的鉴定：多组学分析与实验验证方法
Yanhong Liu,Yirong Ma,Zhijian Song et al.
Yanhong Liu et al.
Background: Atherosclerosis (AS) is a chronic inflammatory disease driven significantly by metabolic reprogramming (MR). However, the core MR-related genes and their specific functions in AS remain incompletely understood...
Kai Wang,Li Wang,Jiamin Ning et al.
Kai Wang et al.
Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a mitochondrial-driven metabolic disorder, yet the specific contributions of individual mitochondrial respiratory chain complexes remain poorly defined. In particular, ...
An interpretability heart disease prediction model based on stacking ensemble with SHAP [0.03%]
基于SHAP stacking集成的可解释性心脏病预测模型
Yanjie Chen,Liqiang Chong,Zhenghao Bao et al.
Yanjie Chen et al.
Introduction: In the big data era, healthcare data has grown exponentially, presenting opportunities to explore the pathogenesis of heart disease. Clarifying the correlations between health indicators and heart disease is...
Editorial: The role of calcium channels in human health and disease, volume III [0.03%]
钙通道在人体健康与疾病中的作用（第三卷）主编词
Peng Zhang,Chang-Bo Zheng,Zhen Chen et al.
Peng Zhang et al.