Non-invasive detection of hTERT mRNA in deep-cough swabs for early diagnosis of lung cancer [0.03%]
深咳拭子中hTERT mRNA非侵入性检测在肺癌早期诊断中的应用研究
Yinhua Liu,Xi Huang,Bing Zhou et al.
Yinhua Liu et al.
Introduction: Lung cancer remains the leading cause of cancer-related mortality globally, with current screening methods like low-dose computed tomography (LDCT) limited by radiation risks and false negatives. Non-invasiv...
Novel drugs targeting genetic variants: current applications and future prospects in heart failure treatment [0.03%]
针对基因突变的新型药物在心力衰竭治疗中的当前应用及未来前景
Xiang Li,Suwen Bai,Yumei Luo
Xiang Li
Chronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes. This study analyzes novel drugs targeting genetic mutations that have been launch...
Artificial intelligence-based miRNA analysis for precision oncology: diagnostic and prognostic insights [0.03%]
基于人工智能的miRNA分析在精准肿瘤学中的诊断和预后见解
Tauqeer Zehra,Maryam Koopaie,Nishat Fatima et al.
Tauqeer Zehra et al.
Background: MicroRNAs (miRNAs), small molecules that fine-tune gene activity, are consistently disrupted in cancer. Found stably in blood and other fluids, their unique cancer-associated patterns offer a promising route f...
Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications [0.03%]
线粒体代谢在癌症干细胞(CSCs)中的作用：分子和诊断意义
Charan Psvv,Sona Sunil,Nandana Thuyyath et al.
Charan Psvv et al.
Cancer stem cells (CSCs) are a self-renewing population often linked to tumor initiation, metastasis, relapse, and resistance to therapy. While bulk tumor cells are often dependent on glycolysis, CSCs demonstrate metabolic plasticity can sw...
Integrated transcriptomic, protein, and MicroRNA profiling reveals a conserved pyroptosis-related molecular signature across breast cancer subtypes [0.03%]
整合转录组、蛋白和MicroRNA谱型可揭示乳腺癌亚型中保守的焦亡相关分子特征
Agata Panfil,Tomasz Sirek,Agata Sirek et al.
Agata Panfil et al.
Background: Pyroptosis, an inflammatory form of programmed cell death, has been implicated in tumor progression, yet its molecular contribution across breast cancer subtypes remains poorly defined. ...
Optimized RTX strategy plus structured glucocorticoid tapering for primary membranous nephropathy: a multicenter propensity score-matched cohort study [0.03%]
优化的RTX方案联合有序糖皮质激素减量治疗原发性膜性肾病：倾向评分匹配队列研究
Yao Sun,Yuxia Zhang,Jing Liu et al.
Yao Sun et al.
Background: Standard rituximab (RTX) regimens for primary membranous nephropathy (PMN) may result in subtherapeutic RTX exposure within 2-3 months due to altered pharmacokinetics, potentially contributing to delayed remis...
Disease classification via interpretable machine learning based on multi-center routine coagulation test [0.03%]
基于多中心常规凝血检测的可解释机器学习疾病分类方法研究
Feng Dong,Yaqiong Zhang,Weibu Chen et al.
Feng Dong et al.
Background: This study aims to establish an interpretable disease classification model via machine learning and identify key features related to the disease to assist clinical disease diagnosis based on a multi-center CX9...
Editorial: Unraveling molecular mechanisms of neurodegenerative disease development: insights from stem cell-derived 2D and 3D in vitro models [0.03%]
述评：利用由干细胞系构建的二维和三维体外模型解析神经退行性疾病的发生机制
Stefania Scalise,Matteo Becatti,Valeria Lucchino
Stefania Scalise
Research progress on the damage of lipid peroxidation to the body and its correlation with metabolic diseases [0.03%]
脂质氧化损伤与代谢性疾病关联的研究进展
Jiali Wang,Hongli Li,Yuhan She et al.
Jiali Wang et al.
Lipid peroxidation is a critical oxidative stress response implicated in the pathogenesis of numerous metabolic diseases, including cardiovascular diseases, diabetes, and non-alcoholic fatty liver disease (NAFLD). While its role in damaging...
Erythropoietin alleviate obstructive renal fibrosis by regulating immunity and inflammation through miR-21-5p/SPRY1/ERK1/2/NF-κB pathway inhibition [0.03%]
促红细胞生成素通过抑制miR-21-5p/SPRY1/ERK1/2/NF-κB通路调节免疫和炎症缓解阻塞性肾纤维化
Erpeng Liu,Xiao Sun,Qilong Liu et al.
Erpeng Liu et al.
The important role of erythropoietin (EPO) in the treatment of renal fibrosis induced by urinary tract obstruction has been documented in numerous studies; however, its underlying molecular mechanisms are not yet fully understood, particula...