External validation of a commercial AI system for pulmonary embolism detection on chest CTPA: a multicenter study [0.03%]
一项关于肺栓塞检测的商业AI系统在胸部CTPA图像上的外部验证的多中心研究
Mireayi Tudi,Saimaitikari Abudoubari,Xierenayi Waresi et al.
Mireayi Tudi et al.
Background: Pulmonary embolism (PE) is a critical cardiovascular emergency requiring prompt, accurate diagnosis. CT pulmonary angiography (CTPA) is the diagnostic gold standard, yet rising case volumes and radiologist sho...
E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies [0.03%]
泛素连接酶的结构多样性、疾病中的功能失调及在靶向治疗策略中的新作用
Srineevas Sriram,Prahalad Krishnakumar,C Sudandiradoss
Srineevas Sriram
The Ubiquitin-Proteasome System (UPS) is a key mechanism of cellular homeostasis. A central part of this mechanism is E3 ubiquitin ligases, which selectively direct proteins to be ubiquitinated for degradation via the UPS. In this review we...
The gut microbiota remodes amino acid and lipid metabolism in incomplete revascularization of CHD with phlegm-dampness syndrome: an integrated multiomics and network pharmacology study [0.03%]
冠心病痰湿证不完全血运重建患者肠道菌群重塑氨基酸和脂质代谢的整合多组学及网络药理学研究
Xinyu Zhang,Wei Jiang,Xiaoqing Li et al.
Xinyu Zhang et al.
Background: Incomplete revascularization of coronary heart disease (IR-CHD) is a novel category of CHD that has developed; such patients often have persistent angina of unknown etiology, which seriously affects quality of...
Protein structure prediction powered by artificial intelligence: from biochemical foundations to practical applications [0.03%]
人工智能驱动的蛋白质结构预测：从生化基础到实用应用
Tianxiang Yin,Yunxuan Chen,Yuhang Wang et al.
Tianxiang Yin et al.
The three-dimensional structure of a protein underpins its biological function, making structure determination and prediction central challenges in structural biology. Although experimental techniques such as X-ray crystallography, nuclear ...
Genetic constraints on protein loop evolution: out-of-frame stop codons limit Bacillus subtilis stationary-phase mutagenesis [0.03%]
蛋白质环进化的基因限制：框移终止密码子限制芽孢杆菌静止阶段的突变性
Carmen Vallin,Mario Pedraza-Reyes,Eduardo Robleto
Carmen Vallin
Insertion and deletion (indel) events in protein-coding DNA are associated with loss-of-function frameshift mutations. In silico studies have found that protein-coding regions are littered with out-of-frame stop codons (OSCs) which may rest...
miRNA-associated gene networks reveal potential candidate markers for Alzheimer's disease [0.03%]
与microRNA相关的基因网络可揭示阿尔茨海默病潜在候补助标基因
Shujuan Pan,Yanfang Zhou,Xiaoyu Wang et al.
Shujuan Pan et al.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory and cognitive decline. Recent studies highlight the significant role of microRNAs (miRNAs) in regulating genes rel...
Gordon C Roberts
Gordon C Roberts
Expression of immune-related genes and possible regulatory mechanisms in ulcerative colitis [0.03%]
溃疡性结肠炎中免疫相关基因的表达及其可能的调控机制
Fanfan Qu,Baoqing Xu,Yi Zhou et al.
Fanfan Qu et al.
Background: The abnormal immune response may lead to lesions of the intestinal mucosal layer in ulcerative colitis (UC). Immune-related genes (IRGs) are crucial for the immunological reaction in UC. However, the IRGs and ...
Capturing protein-protein interactions in plants: recent advances, challenges, and opportunities [0.03%]
植物蛋白质-蛋白质相互作用的捕获：近期进展、挑战和机遇
Berry Dickey,Yatendra Singh,Sibesh Maharjan et al.
Berry Dickey et al.
Plants rely on dynamic protein-protein interaction (PPI) networks to carry out routine functions (such as photosynthesis and respiration) and responses to environmental cues. Therefore, capturing dynamic PPIs is critical for understanding m...