TUBB2A expression and its prognostic significance in hepatocellular carcinoma revealed by cholesterol-metabolism-related gene profiling [0.03%]
胆固醇代谢相关基因谱型显示的肝细胞癌中TUBB2A表达及其预后意义
Shiwei Zhu,Yatong Ruan,Mengqi Zhao et al.
Shiwei Zhu et al.
Introduction: Hepatocellular carcinoma (HCC) exhibits significant molecular heterogeneity and is associated with a poor prognosis. The lack of validated biomarkers limits early diagnosis and effective prognosis. Identifyi...
A prognostic nomogram for colorectal cancer based on ubiquitin-specific protease 21 expression: a retrospective cohort study [0.03%]
基于泛素特异性蛋白酶21表达的结直肠癌预后 Nomogram：一项回顾性队列研究
Hua Chen,Tianhao Lao,Tong Shen et al.
Hua Chen et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, and substantial prognostic heterogeneity exists among patients with similar TNM stages. Ubiquitin-specific protease 21 (US...
Optimization of protein extraction and digestion workflows for proteomic analysis of saliva, salivary stones and kidney stones [0.03%]
优化蛋白质提取和消化工作流程以进行唾液、腮腺结石和肾结石的蛋白组分析
Natalia Musiał,Martyna Iwaniec,Inez Mruk et al.
Natalia Musiał et al.
Background: Salivary and kidney stone diseases are associated with pathological calcification, yet their molecular composition remains incompletely characterized. Proteomic analysis of saliva and stone material may provid...
Efficiency and safety of five different agents for in vivo delivery of novel bioengineered RNAi molecules [0.03%]
五种不同制剂体内递送新型生物工程RNAi分子的效率及安全性
Su Guan,Mei-Juan Tu,Yan-Ju Li et al.
Su Guan et al.
RNA molecules have emerged as an addition to existing entities for therapy and vaccination, whose success may be hindered by inefficient in vivo delivery or induction of excessive toxicities, such as severe cytokine release syndrome. In thi...
Mitochondrial respiration in human peripheral blood mononuclear cells: methodology and influence of permeabilization and storage [0.03%]
人外周血单个核细胞的线粒体呼吸：方法学和通透化及保存的影响
Shusuke Sekine,Imen Chamkha,Evelina Elmér et al.
Shusuke Sekine et al.
Human peripheral blood mononuclear cells (PBMCs) can be easily sampled from healthy individuals and patients. Density gradient isolation from human blood or leukocyte concentrates yields a mononuclear cell population of mainly lymphocytes, ...
Non-coding RNA biomarkers in resistant hypertension: a scoping review [0.03%]
难治性高血压中非编码RNA生物标志物的研究：系统综述
Robert Błaszczyk,Maciej Biskupski,Łukasz Wiśniowski et al.
Robert Błaszczyk et al.
Objective: To map and synthesize human evidence on circulating non-coding RNAs (ncRNAs) evaluated as biomarkers in resistant hypertension (RH), including associations with RH phenotypes, target-organ damage, and short-ter...
Research on the role and mechanisms of Cystatin 6 in disease pathosis and development [0.03%]
半胱氨酸蛋白酶抑制剂cystatin 6在疾病发生发展中的作用及机制研究
Yunhua Li,Xuehong Long,Gangwen Chen et al.
Yunhua Li et al.
The Cystatin 6 (CST6 [also known as Cystatin E/M]) is a cysteine protease inhibitor that exhibits a dual role in various types of tumors, acting as either a suppressor or promoter. In non-oncological contexts, CST6 maintains skin barrier ho...
Molecular mechanisms of phytohormone ABA-regulated anthocyanin biosynthesis in grape berry: an epigenetic dual-gating hypothesis within a five-layer regulatory framework [0.03%]
ABA调控葡萄浆果花青素生物合成的分子机制：五层次调控框架内的表观遗传双门控模式假说
Yao Wang,Xiaohan Duan,Rui Xu et al.
Yao Wang et al.
Anthocyanin biosynthesis in grape berries is a complex process regulated by the phytohormone abscisic acid, yet the molecular mechanisms underlying cultivar-specific responses and environmental memory remain poorly understood. This review p...
Integrated expression quantitative trait loci and Mendelian randomization analyses of the candidate genes and pathways identified for myocardial infarction [0.03%]
心肌梗死候选基因和通路的表达定量性状位点与孟德尔随机化综合分析
Peichun He,Xiangwen Lv,Chuwen Fu et al.
Peichun He et al.
Background: Myocardial infarction (MI) is a myocardial necrosis event caused by an unstable ischemic state that reduces life expectancy primarily through cardiac functional impairment and cardiomyocyte death. The present ...
Exploring hub genes related to adipocytokines in keloids: a combined analysis integrating single-cell, Mendelian randomization and bulk transcriptome data with experimental verification [0.03%]
结合单细胞、孟德尔随机化和批量转录组数据分析探索与脂肪细胞因子相关的瘢痕疙瘩枢纽基因并进行实验验证
Maisude Mahemuti,Youyou Cheng,Minxuan Li et al.
Maisude Mahemuti et al.
Background: Keloids are fibroproliferative skin tumors with excessive collagen deposition and are strongly linked to adipocytokine dysregulation. However, the underlying mechanisms remain unclear. This study aimed to iden...