Natural killer cell activated by attenuated newcastle disease virus (NDV) as anti-cancer therapy [0.03%]
减毒新城疫病毒活化自然杀伤细胞的抗肿瘤作用研究
Noor N Al-Hayani,Marwa I Salman,Ahmed Majeed Al-Shammari
Noor N Al-Hayani
Background: Natural Killer (NK) cells play a central role in innate immunity by targeting virally infected and malignant cells without prior sensitization. However, their activity is often suppressed within the tumor micr...
Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms [0.03%]
基于人体皮肤细胞的氯原酸与牛磺酸处理的转录组分析研究揭示了细胞衰老机制的新见解
Beomsu Kim,Joong-Gon Shin,In-Shik Hong et al.
Beomsu Kim et al.
Background: Chlorogenic acid (CGA) and taurine are well-known antioxidant compounds reported to reduce skin cellular senescence. However, the biological mechanisms underlying their skin-protective effects remain unclear. ...
Navigating the molecular landscape: integrated multiomics liquid biopsy for biomarker discovery in early detection and monitoring of colorectal cancer [0.03%]
导航分子景观：用于早期发现和监测结直肠癌生物标志物发现的集成多组学液体活检
Xuanqiang Fan,Jinyu Shi,Yiwan Shang et al.
Xuanqiang Fan et al.
The elevated mortality associated with colorectal cancer is largely due to delayed diagnosis and post-treatment disease recurrence, highlighting the urgent clinical need for molecular markers with exceptional sensitivity and specificity to ...
Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel case presentation [0.03%]
病例报告：马尔凯法瓦-比尼阿米病：一种新型病例表现的潜在病因因素—— parietal 细胞抗体
Junhao Zhang,Lizhen Wang,Shuangfeng Yang et al.
Junhao Zhang et al.
Marchiafava-Bignami disease (MBD) represents a rare neurological disorder predominantly associated with chronic ethanol consumption and thiamine insufficiency. However, its possible correlation with cobalamin deficiency resulting from anti-...
HOS1-mediated both ubiquitination and nuclear-import are crucial to nitrate signaling [0.03%]
HOS1介导的泛素化和核输入对硝酸盐信号转导至关重要
Lin-Bei Xie,Xin-Yue Yang,Zhong-Wei Zhang et al.
Lin-Bei Xie et al.
Multi-omics integration identifies PGAP3 as a tumor-intrinsic factor associated with CD8+ T-cell exclusion in prostate cancer [0.03%]
多组学整合分析识别出PGAP3是前列腺癌中与CD8+T细胞排斥相关的肿瘤固有因素
Weihao Liu,Guoping Li,Yan Lei et al.
Weihao Liu et al.
Background: Prostate cancer (PCa) is prototypically immunologically "cold", characterized by low tumor mutational burden, sparse CD8+ T-cell infiltration, and resistance to immune checkpoint blockade. The tumor cell-intri...
Differences in concentration of neuron-specific enolase (NSE), neutrophil elastase (NE), and calcium-binding protein S100B in viral diseases: a pilot study focused on normoglycemic COVID-19 patients [0.03%]
神经特异性烯醇化酶(NSE)、中性粒细胞弹性蛋白酶(NE)和钙结合蛋白S100B在病毒感染中的浓度差异：以非糖尿病COVID-19患者为重点的初步研究
Joanna Adamiec-Mroczek,Agnieszka Bronowicka-Szydełko,Łukasz Lewandowski et al.
Joanna Adamiec-Mroczek et al.
SARS-CoV-2 infection is characterized by a wide spectrum of clinical severity. Despite more than 2 years having passed since the end of the COVID-19 pandemic, the virus's properties continue to form the basis for developing diagnostic and t...
Next-generation viral detection through AI-enhanced nanotechnology: advances, challenges, and future directions [0.03%]
人工智能增强纳米技术的下一代病毒检测：进展、挑战与未来方向
Pankaj Garg,Gargi Singhal,Sharad S Singhal
Pankaj Garg
Emerging viral outbreaks, such as the COVID-19 pandemic, have highlighted the critical need for rapid, accurate, and scalable virus detection systems. This review aims to explore the integration of artificial intelligence (AI) and nanotechn...
Emanuele Bobbio,Martina Caiazza,Giuseppe Limongelli et al.
Emanuele Bobbio et al.
Expanding the genetic code: phage-driven evolution of pyrrolysyl-synthetase for site-specific incorporation of synthetic phenylalanine and tyrosine derivatives [0.03%]
扩大遗传密码：利用噬菌体驱动的吡咯赖氨酰-tRNA合成酶进化在特定位点融合人工合成的苯丙氨酸和酪氨酸的方法
Anastasia Dakhnevich,Sabina Miasoutova,Danila Iliushin et al.
Anastasia Dakhnevich et al.
Introduction: Pyrrolysyl-tRNA synthetase (PylRS) is a key enzyme for the site-specific incorporation of non-canonical amino acids (ncAAs) into proteins. However, its native form has a limited substrate scope. This study a...