Comparative analysis of tissue-specific anticancer peptide prediction models: ACP-Boost framework [0.03%]
基于ACP-Boost框架的组织特异性抗肿瘤肽预测模型比较分析
Ruizhe Kang,Weichen Yuan,Mingjun Tang et al.
Ruizhe Kang et al.
Cancer remains a major global health burden, and conventional treatments such as surgery, radiotherapy, and chemotherapy are often limited by systemic toxicity, drug resistance, and high cost. Anticancer peptides (ACPs) have emerged as prom...
Spatial localization of arachidonic acid in human carotid atherosclerotic plaques reveals a pro-inflammatory metabolic program in macrophages [0.03%]
人颈动脉斑块中花生四烯酸的时空分布揭示了巨噬细胞中的促炎代谢程序
Jiaxin Wan,Rijin Lin,Zhouyang Jiao et al.
Jiaxin Wan et al.
Background: Carotid atherosclerosis is a significant cause of ischemic stroke. It is a chronic inflammatory disease characterized by the progressive accumulation of inflammatory cells and mediators. Specific key metabolit...
Revealing key genes and molecular mechanisms associated with dietary restriction in ulcerative colitis [0.03%]
揭示与溃疡性结肠炎饮食限制相关的关键基因和分子机制
Yingying Li,Min Xu,Wen Li et al.
Yingying Li et al.
Introduction: Ulcerative colitis (UC) is characterized by chronic colonic mucosal inflammation, with its pathogenesis involving multidimensional interactions and limitations in clinical treatment. Dietary restriction (DR)...
Xiaoqian Zhang,Yanping Zhang,Zhenguo Zhai et al.
Xiaoqian Zhang et al.
The Transmembrane protein 45 (TMEM45) family comprises multi-pass transmembrane proteins that harbor the ancient DUF716 domain and are predominantly localized to the endomembrane system (endoplasmic reticulum, Golgi apparatus). In mammals, ...
Prognostic impact of the lymph node yield on survival in patients with stage I lung adenocarcinoma receiving sublobar resection [0.03%]
亚肺叶切除术治疗I期肺腺癌患者淋巴结采样数目对生存影响的研究
Yongzhong Li,Jiangtao Li,Xuejun Xu et al.
Yongzhong Li et al.
Introduction: It remains controversial regarding the prognostic impact and therapeutic implications for immunotherapy of lymph node yield (LNY) during sublobar resection (SR) on stage I lung adenocarcinoma (LUAD). ...
Bioinformatics combined with machine learning for the identification of malignant transformation markers in colorectal polyps [0.03%]
结合生物信息学和机器学习鉴定 colorectal 息肉恶性转化标记物
Tao He,Caixia Liang,Kui Li et al.
Tao He et al.
Background: Colorectal polyps, as crucial precancerous lesions of colorectal cancer (CRC), have incompletely clarified origin and evolutionary mechanisms, which restrict the early prevention and control of CRC. This study...
Mining personalized core traditional Chinese medicine prescriptions for rheumatoid arthritis and elucidating their mechanisms via frequent closed Itemset compression and multilevel network pharmacology [0.03%]
基于频繁闭合项集压缩和多层网络药理学的类风湿关节炎个性化核心中药开具规律的挖掘及作用机制探讨
Xu Chen,Jinlong Yu,Xin Dong et al.
Xu Chen et al.
Introduction: Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disease involving multiple dysregulated signaling pathways and marked inter-individual heterogeneity in treatment response. In real-world c...
Screening of potential oxidative stress-related biomarkers and therapeutic drugs in rheumatoid arthritis based on integrative bioinformatics, machine learning, and molecular dynamics simulations [0.03%]
基于集成生物信息学、机器学习和分子动力学模拟的类风湿关节炎潜在氧化应激相关生物标志物和治疗药物筛选研究
Zhigang Shi,Wenzhuo Qi,Juyin Xue et al.
Zhigang Shi et al.
Background: Rheumatoid arthritis (RA) is a prevalent autoimmune condition. Increasing evidence reveals that oxidative stress exerts an important effect in the pathogenesis of RA. This research aimed to systematically scre...
Recent advances in m6A RNA modification in hepatocellular carcinoma: from mechanisms to therapeutic potential [0.03%]
m6A RNA修饰在肝癌领域中的研究进展：从机制到治疗潜力
Qingmiao Shi,Yingru Liu,Mengjuan Xuan et al.
Qingmiao Shi et al.
Hepatocellular carcinoma (HCC) remains a major global health burden due to its high incidence and mortality, underscoring the urgent need to elucidate the molecular mechanisms of HCC and to improve diagnosis and therapeutic approaches. As t...
Zhanlin Ji,Li Zhao,Ivan Ganchev
Zhanlin Ji