Protein aggregation and therapeutic strategies in SOD1- and TDP-43- linked ALS [0.03%]
SOD1和TDP-43相关的渐冻症的蛋白聚集及治疗方法
Maria Tsekrekou,Maria Giannakou,Katerina Papanikolopoulou et al.
Maria Tsekrekou et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with severe socio-economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic inclusions composed of misfolded and aggregated proteins, includ...
Sara Carvalhal,Bruno Carmona,Anne-Marie Tassin et al.
Sara Carvalhal et al.
Bioinformatics study of the potential therapeutic effects of ginsenoside Rh3 in reversing insulin resistance [0.03%]
白桦皂苷Rh3通过改善IR治疗NAFLD的网络药理学研究
Yayun Wang,Dongming Wu,Yongxin Wang et al.
Yayun Wang et al.
Background: In recent years, the incidence of insulin resistance is increasing, and it can cause a variety of Metabolic syndrome. Ginsenosides have been clinically proven to improve fat metabolism and reduce insulin resis...
Performance evaluation of a SARS-CoV-2 and influenza A/B combo rapid antigen test [0.03%]
SARS-CoV-2和流感A/B组合型快速抗原检测试剂盒的性能评估
Kevin P Rosenblatt,Hugo Romeu,Camille Romeu et al.
Kevin P Rosenblatt et al.
Introduction: The global COVID-19 pandemic and seasonal influenza outbreaks have drawn attention to the critical need for accurate and efficient diagnostic tools. Methods: The performance of the InstaView COVID-19/Flu Ag Combo Test, which w...
Wei Qian,Jun Ye,Sheng Xia
Wei Qian
Dendritic cells (DCs) are involved in the initiation and maintenance of immune responses against malignant cells by recognizing conserved pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) throug...
Screening of drug targets for tuberculosis on the basis of transcription factor regulatory network and mRNA sequencing technology [0.03%]
基于转录因子调控网络和mRNA测序技术的结核病药物靶点筛选研究
Shuai Wang,Na Yan,Yue Yang et al.
Shuai Wang et al.
Background: Tuberculosis is a worldwide epidemic disease, posing a serious threat to human health. To find effective drug action targets for Mycobacterium tuberculosis, differentially expressed genes in tuberculosis patie...
Comprehensive landscape of junctional genes and their association with overall survival of patients with lung adenocarcinoma [0.03%]
肺腺癌连接基因的综合景观及其与患者总生存期的关联研究
Bin Xie,Ting Wu,Duiguo Hong et al.
Bin Xie et al.
Objectives: Junctional proteins are involved in tumorigenesis. Therefore, this study aimed to investigate the association between junctional genes and the prognosis of patients with lung adenocarcinoma (LUAD). ...
Pseudomonas aeruginosa gene PA4880 encodes a Dps-like protein with a Dps fold, bacterioferritin-type ferroxidase centers, and endonuclease activity [0.03%]
恶臭假单胞菌基因PA4880编码一种具有Dps折叠、细菌铁蛋白型Fe氧化中心和内切脱氧核糖核酸酶活性的Dps样蛋白
Nimesha Rajapaksha,Huili Yao,Aisha Cook et al.
Nimesha Rajapaksha et al.
We report the biochemical, structural, and functional characterization of the protein coded by gene PA4880 in the P. aeruginosa PAO1 genome. The PA4880 gene had been annotated as coding a probable bacterioferritin. Our structural work shows...
DiffraGAN: a conditional generative adversarial network for phasing single molecule diffraction data to atomic resolution [0.03%]
用于单分子衍射数据到原子分辨率的相位恢复的条件生成对抗网络（DiffraGAN）
S Matinyan,P Filipcik,E van Genderen et al.
S Matinyan et al.
Introduction: Proteins that adopt multiple conformations pose significant challenges in structural biology research and pharmaceutical development, as structure determination via single particle cryo-electron microscopy (...
Editorial: Molecular mechanisms underlying polycystic kidney disease: from the smallest bricks to the big scenario [0.03%]
编辑部：多囊肾病的分子机制：从最基本的构造块到整体画面
Annarita Di Mise,Michael J Caplan,Giovanna Valenti
Annarita Di Mise