Unraveling the role of lactylation in cell death and correlative diseases: a comprehensive review [0.03%]
乳酰化在细胞死亡及相关疾病中的作用机制：全面综述
Bowen Zhao,Yue Liu,Xinpei Shen et al.
Bowen Zhao et al.
Lactylation is a newly identified post-translational modification and an important biological function of lactate. Numerous pathological disorders, including cancer and autoimmune and inflammatory diseases, are regulated by lactylation. Add...
Association of triglyceride glucose index and volumetric bone mineral density in T2DM: fat distribution as a potential indirect link [0.03%]
T2DM患者胰岛素抵抗与骨密度的关联：脂肪分布可能是潜在的间接联系
Bei Huang,Feng Xu,Jun-Jie Yang et al.
Bei Huang et al.
Background: Patients with type 2 diabetes mellitus (T2DM) generally present with insulin resistance, central obesity, and increased risk of fragility fracture. But the factors contributing to impaired bone health in T2DM ...
Xuan Liao,Hongkai Gao,Mengtian Bai et al.
Xuan Liao et al.
The diagnosis and treatment of corneal diseases still face many challenges. As nanoscale vesicles (30-150 nm in diameter), exosomes facilitate intercellular communication by transporting bioactive molecules such as proteins and nucleic acid...
Decoding the secretory blueprint of bone healing: from gradients to regeneration [0.03%]
解读骨骼愈合的分泌蓝图：从浓度梯度到再生医学
Wenxiao Yang,Yuanfang Wang,Keda Liu et al.
Wenxiao Yang et al.
Bone tissue regeneration constitutes a complex biological process involving the coordinated regulation of multiple cell types and signaling pathways. As essential mediators of intercellular communication, secreted proteins play a pivotal ro...
Urolithin A enhances mitochondrial biogenesis-related markers and maximal respiratory capacity during C2C12 differentiation [0.03%]
うrolethin A可增强C2C12分化过程中的线粒体生物标志物和最大呼吸能力
Ronald Vargas-Foitzick,Diego Irribarra-Tapia,Mayalen Valero-Breton et al.
Ronald Vargas-Foitzick et al.
Introduction: Skeletal muscle differentiation in the C2C12 myoblast model requires extensive mitochondrial remodeling to meet rising bioenergetic demands through coordinated changes in biogenesis, dynamics, and respirator...
Inflammation-induced osteogenic signaling promotes calcium phosphate crystal formation in kidneys via MAPK, NF-κB, and smad pathways [0.03%]
炎症诱导的促骨形成信号通过MAPK、NF-κB和Smad途径促进肾脏内钙磷酸盐晶体形成
Yi-Shiou Tseng,Hsing-I Tseng,Po-Wen Ku et al.
Yi-Shiou Tseng et al.
Introduction: Approximately two-thirds of patients with kidney stones exhibit Randall's plaques, interstitial calcium phosphate deposits extending to the papillary surface, serving as stone formation niduses. Although inf...
Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity [0.03%]
人工智能辅助的视网膜结构和血管改变定量分析揭示了视网膜图案化是近视严重程度的稳健生物标志物
Luxiang Sun,Dongqing Yuan,Chenfeng Gu et al.
Luxiang Sun et al.
Background: Myopia is characterized by progressive axial elongation and structural remodeling of the posterior segment, ultimately leading to irreversible visual impairment in high myopia. However, early, noninvasive biom...
Endothelial-to-mesenchymal transition in atherosclerosis: mechanisms, therapeutic targets, and future perspectives [0.03%]
动脉粥样硬化中内皮细胞向间充质细胞转化：机制、治疗靶点和未来展望
Xiaoshan Cui,Yuanyuan Chen,Hailang Luo et al.
Xiaoshan Cui et al.
Endothelial-to-mesenchymal transition (EndMT) is an endothelial plasticity program that contributes to vascular remodeling, inflammation, extracellular matrix remodeling, calcification, and plaque instability in atherosclerosis. Recent line...
STEAP4 drives immune dysregulation in myocardial infarction-NSCLC comorbidity [0.03%]
STEAP4介导的心肌梗死和非小细胞肺癌合并症中免疫稳态失调机制研究
Zhonghe Liu,Yuxi Yi,Wenwen Li et al.
Zhonghe Liu et al.
Introduction: Myocardial infarction (MI) and non-small cell lung cancer (NSCLC) are leading causes of morbidity and mortality worldwide, with increasing evidence pointing to a complex comorbidity between them. However, th...
Development and validation of an explainable machine learning model for mortality prediction in ICU patients with lung cancer [0.03%]
用于预测肺癌重症监护患者死亡率的可解释机器学习模型的开发和验证
Jinhong Xia,Jingyuan Zhang,Siyu Zhang et al.
Jinhong Xia et al.
Background and objective: Lung cancer is the leading cause of cancer-related death worldwide, with a particularly high mortality risk among patients admitted to the intensive care unit (ICU). Accurate and timely predictio...