Yubo Zhao,Hang Li,Jiaqiao Zhong et al.
Yubo Zhao et al.
FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rate irradiation (>40 Gy/s), has emerged as a promising strategy for expanding the therapeutic window by sparing normal tissues while preserving tumor control. This review prop...
The glioblastoma ecosystem: clonal evolution, heterogeneity, and therapeutic resistance [0.03%]
胶质母细胞瘤生态系统：克隆进化、异质性和治疗抵抗性
Ying He,Wenxue Song,Shuo Li et al.
Ying He et al.
Therapeutic resistance and recurrence represent major clinical challenges in glioblastoma (GBM), driven by profound tumor heterogeneity and continuous clonal evolution under therapeutic pressure. Conventional diagnostic and therapeutic stra...
Matrix stiffness may drive multi-cellular crosstalk via YAP signaling in biliary atresia liver fibrosis: a mechanistic review [0.03%]
基质刚度可能通过YAP信号途径驱动胆道闭锁肝纤维化中的多细胞交叉对话：机制综述
Jiwen Cheng
Jiwen Cheng
Background: Biliary atresia (BA) is a devastating liver disease in infants. It leads to progressive cholangitis and fibrosis. In BA, the liver builds up too much extracellular matrix (ECM) and crosslinks it. That makes th...
Microprotein, macro-effect: DWORF as a therapeutic strategy in heart failure [0.03%]
微蛋白巨效果：心脏衰竭治疗的新策略—— DWORF蛋白质的作用机制研究
Joseph P Verry,Catherine A Makarewich
Joseph P Verry
Heart failure (HF) is a global health crisis and remains a leading cause of morbidity, mortality, and healthcare expenditure despite substantial advances in pharmacological and device-based therapy. Impaired sarcoplasmic reticulum (SR) Ca2+...
Targeting TKT-associated immunometabolic remodeling attenuates experimental lupus nephritis and NET-related inflammation [0.03%]
靶向TKT相关免疫代谢重塑减轻实验性狼疮肾炎和NET相关炎症
Litong Zhu,Taoyan Lin,Lai Yee Cheong et al.
Litong Zhu et al.
Lactic acid metabolism and neutrophil extracellular traps (NETs) are critical immune regulators, yet their specific crosstalk in systemic lupus erythematosus (SLE) and lupus nephritis (LN) pathogenesis remains poorly understood. Here, by in...
Transcription factors ETV4 and ETV5 are required for nephron progenitor cell maintenance, distal nephron development and connection to the collecting system [0.03%]
ETS转录因子ETV4和ETV5对肾原基细胞维持、远端肾小管发育及与集合管系统连接的作用不可或缺
Kaitlin Day,Konrad Thorner,Milanya Thumma et al.
Kaitlin Day et al.
The functional unit of the kidney, the nephron, is composed of the renal corpuscle and the renal tubule that includes proximal tubule, loop of Henle, distal and connecting tubule. Each of these segments perform distinct and complementary ro...
Transcriptome analysis of goat adipose tissue-derived mesenchymal stem cells cultured in variable oxygen conditions [0.03%]
山羊脂肪组织间充质干细胞不同氧浓度培养的转录组分析
Utkarsha Vishwakarma,Michelle Abraham,Ibraz Kori et al.
Utkarsha Vishwakarma et al.
Introduction: Oxygen tension influences mesenchymal stem cell biology, but the transcriptional responses of goat adipose tissue-derived mesenchymal stem cells (gADSCs) to different oxygen-exposure conditions remain incomp...
Advances in drug addiction research using Caenorhabditis elegans: behavioral and molecular mechanisms [0.03%]
利用秀丽隐杆线虫研究药物成瘾进展：行为与分子机制
Lihua Yang,Shuang Wu,Jiale Liu et al.
Lihua Yang et al.
Drug addiction is a complex, chronic, and relapsing neurological disorder characterized by persistent neuroadaptation and a substantial public health burden. Because of its simple nervous system, genetic tractability, short life cycle, tran...
Quantitative analysis of retinal microvascular changes in gestational hypertension and preeclampsia using artificial intelligence technology [0.03%]
基于人工智能技术的子痫前期和妊娠高血压综合征视网膜微血管变化的量化分析
Tingting Hu,Shen Hu,Di Luo et al.
Tingting Hu et al.
Hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and perinatal morbidity and mortality worldwide. Current clinical diagnosis primarily relies on late-onset indicators including elevated blood pressure and p...
A pipeline for cell migration analysis in live-cell imaging data from human iPSC-derived forebrain assembloids [0.03%]
人诱导多能干细胞来源的大脑组装体活细胞成像数据中细胞迁移分析的管道技术
Maya P Weidman,Natalie Baker Campbell,Cody Headings et al.
Maya P Weidman et al.
During forebrain development, inhibitory interneurons and oligodendrocyte progenitor cells migrate long distances into the developing dorsal cortex. Human induced pluripotent stem cell-derived forebrain assembloids (FAs) provide direct expe...