Decoding NETosis-associated immune dysregulation in diffuse large B-cell lymphoma through integrative multi-omics and machine learning [0.03%]
通过整合多组学和机器学习解码弥漫性大B细胞淋巴瘤中与NETosis相关的免疫失调
Hanbing Yao,Gangfeng Wang,Yingmin Liang et al.
Hanbing Yao et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy driven by complex immune dysregulation, yet the role of NETosis, a distinct neutrophil immune effector program, in the tumor immune microenvi...
Automated macular hole staging on optical coherence tomography using an optimized ResNet-18 framework [0.03%]
基于优化ResNet-18框架的眼科光学相干层析成像自动黄斑孔分期研究
Zou Jianjun,Xu Tao,Yang Bo et al.
Zou Jianjun et al.
Purpose: To develop and validate a deep learning model for automated macular hole (MH) staging using optical coherence tomography (OCT) images. Methods: ...
Transient biological response of human mesenchymal stem cells to a single wideband high-power electromagnetic pulse exposure: a preliminary study [0.03%]
人单个宽带高强度电磁脉冲暴露的间充质干细胞的瞬时生物学反应初步研究
Alicja Trębińska-Stryjewska,Monika Dobrzyńska,Rafał Bogdan Lewandowski et al.
Alicja Trębińska-Stryjewska et al.
This preliminary study examines the effects of a single wideband high-power electromagnetic (HPEM) pulse on human bone marrow-derived mesenchymal stem cells (hBM-MSCs). The exposure was designed to emulate a realistic electromagnetic exposu...
Advances in organoid imaging and automated morphometric analysis: from optical microscopy to computational approaches [0.03%]
类器官成像及自动形态分析的新进展：从光学显微镜到计算方法
Anna V Zubova,Ivan V Simkin,Roman V Shumilin et al.
Anna V Zubova et al.
Researchers worldwide are increasingly interested in methods for reproducing organogenesis by culturing spheroids and organoids. Unlike spheroids, organoids are more closely related to organs in structure and functional activity. Due to the...
Icariin alleviates triptolide-induced testicular vacuolization via modulating germline ferroptosis and blood-testis barrier integrity [0.03%]
淫羊藿次黄酮通过调节生精小管铁死亡及血睾屏障完整性治疗雷公藤内酯所致睾丸损害
Lei He,Xiwen Yang,Tiantian Wu et al.
Lei He et al.
Introduction: Environmental factors mediated testicular vacuolization injury is a prevalent occurrence, and its etiology and mitigation strategies have long remained inadequately elucidated. ...
Bleeding and hemostatic defects in Lowe syndrome: the role of OCRL in platelets [0.03%]
Lowe综合征的出血和止血缺陷：OCRL在血小板中的作用
Ana Bura,Antonija Jurak Begonja
Ana Bura
Lowe syndrome (LS) is an X-linked disorder caused by OCRL mutations, encoding a phosphatidylinositol 5-phosphatase. OCRL regulates phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2]-dependent cytoskeletal dynamics and membrane trafficking ...
Standardised dual-flow cytometry workflows for quantitative assessment of mitochondrial superoxide and mitochondrial mass in live cancer cells and primary multiple myeloma cells [0.03%]
用于活癌细胞和原发性多发性骨髓瘤细胞线粒体超氧化物和线粒体质量的定量评估的标准双流式细胞术工作流程
Eugenia Giglio,Martina Giuseffi,Marzia Sichetti et al.
Eugenia Giglio et al.
Mitochondrial metabolism plays a critical role in carcinogenesis and cancer progression. Quantitative assessment of mitochondrial function in live cells remains technically challenging because existing biochemical assays lack single-cell re...
Epitranscriptomic control of epithelial-mesenchymal transition in cancer: mechanisms, plasticity, and therapeutic opportunities [0.03%]
癌症上皮间质转化的表转录组调控：机制、可塑性和治疗机会
Juan Luo,Xiulin Jiang,Chongxin Li
Juan Luo
Epithelial-mesenchymal transition (EMT) is a flexible cell-state program that supports tumor invasion, metastasis, immune escape, and therapy resistance. It is not a simple switch from an epithelial to a mesenchymal phenotype. Instead, canc...
Research progress of cuproptosis, ferroptosis, apoptosis, and autophagy in knee osteoarthritis [0.03%]
铜死亡、铁死亡、凋亡和自噬在膝骨关节炎中研究进展
He Shang,Tao Ma,Yuan Wei et al.
He Shang et al.
Knee osteoarthritis (KOA) is a highly prevalent chronic degenerative joint disorder characterized by progressive articular cartilage degeneration, chondrocyte death, and extracellular matrix degradation. Accumulating evidence indicates that...
DeepKaryo-Check: a two-stage automated screening framework for chromosomal numerical and structural abnormalities in clinical karyotype analysis [0.03%]
深度核型检查：临床核型分析中染色体数目和结构异常的两阶段自动化筛查框架
Wenjing Li,Xiaoyan Liang,Hongjian Yu et al.
Wenjing Li et al.
Introduction: Chromosomal abnormalities, including numerical abnormalities such as aneuploidy and structural abnormalities such as microdeletions and complex rearrangements, remain challenging to detect in a stable and re...