Integrative multi-omics and mendelian randomization reveal the critical role of pyroptosis in prognosis and therapy of lung squamous cell carcinomas [0.03%]
整合多组学和孟德尔随机化揭示pyroptosis在肺鳞状细胞癌预后和治疗中的关键作用
Taihao Wang,Wei Zhang,Zhihao He et al.
Taihao Wang et al.
Background: Most types of programmed cell death (PCD) have been demonstrated to play critical roles in the pathogenesis and prognosis of lung squamous cell carcinoma (LUSC). However, the specific type of PCD with the most...
Artificial intelligence-quantified fundus tessellated density and its association with myopia severity in Chinese children: a cross-sectional study [0.03%]
基于人工智能量化的眼底网格密度与中国儿童近视严重程度相关性的横断面研究
Nan Liu,Zhaosheng Li,Xue Zhang et al.
Nan Liu et al.
Introduction: To quantitatively assess the whole fundus tessellated density (FTD) using artificial intelligence (AI) and evaluate its association with myopia severity in Chinese children with myopia. ...
Prognostic value of C-reactive protein-albumin-lymphocyte index (CALLY) in patients with endometrial cancer under radical surgery [0.03%]
基线CALY指数对子宫内膜癌患者预后价值的研究
Yi Zhang,Lin Xu,He Li
Yi Zhang
Background: The C-reactive protein-albumin-lymphocyte (CALLY) index has been reported to possess prognostic utility in several malignancies. However, its relevance in endometrial cancer (EC) has not been fully elucidated....
Diquat-induced organ toxicity: a focus on regulated cell death pathways and mitochondrial dysfunction [0.03%]
哒fongt因诱导的器官毒性：调控细胞死亡途径和线粒体功能障碍的重点研究对象
An-Bu Liu,Yue Shen,Li-Shan Yang et al.
An-Bu Liu et al.
Diquat (1,1'-ethylene-2,2'-bipyridyl, DQ) is a herbicide widely used for weed control in both agricultural and non-cultivated areas. Although its acute toxicity is lower than that of paraquat, its high-water solubility and stability in acid...
Integrated molecular analysis of granulosa cells and follicular fluid extracellular vesicles reveals predictive biomarkers of oocyte maturation in the southern white rhinoceros [0.03%]
整合分子分析揭示南方白犀卵泡颗粒细胞和卵泡液外泌体中预测卵母细胞成熟的生物标志物
Ahmed Gad,Kristin Klohonatz,Nico G Menjivar et al.
Ahmed Gad et al.
Introduction: Assisted reproductive technologies (ARTs) are an imperative conservation tool to rescue species from extinction. An essential step towards technological advancements and ARTs' successes is identifying optima...
A human intestinal epithelial-mesenchyme-immune triple culture system for disease modelling [0.03%]
人源肠道上皮-间充质-免疫三联共培养系统促进疾病建模
Joep Korsten,Alessandro Dei,Carlemi Calitz et al.
Joep Korsten et al.
Introduction: The intestinal mucosa plays a vital role in nutrient absorption, drug metabolism, and pathogen defence. Advances in single-cell technologies have highlighted the specialised roles of various cell types that ...
An explainable machine learning framework for accurate prediction of postoperative anterior chamber depth in highly myopic cataract surgery [0.03%]
一种可解释的机器学习框架，用于准确预测高度近视白内障手术后的前房深度
Yuyang Yang,Haoqiang Cui,Jiajia Gao et al.
Yuyang Yang et al.
Purpose: To develop and validate machine learning models for predicting postoperative anterior chamber depth (ACD) in highly myopic cataract patients based on preoperative biometric parameters. ...
Targeting tubular epithelial cell metabolism to halt renal fibrosis: current evidence and future directions [0.03%]
针对肾小管上皮细胞代谢抗肾纤维化的靶点：现有证据及未来方向
Wenke Liu,Xing Zhao
Wenke Liu
Renal fibrosis is a common pathological endpoint of chronic kidney disease, characterized by excessive deposition of extracellular matrix and loss of functional nephrons. Emerging evidence highlights that profound metabolic reprogramming is...
Pbx1 and Pbx3 cooperatively regulate intermediate progenitor genesis and corticogenesis in the mouse neocortex [0.03%]
PBX1和PBX3在调控小鼠新皮层中间前体发生及皮层发育过程中的协同作用
Asisa Muchamedin,Pauline A Ulmke,Linh Pham et al.
Asisa Muchamedin et al.
Intermediate progenitor cells (IPCs) are key amplifying neuronal precursors that generate the majority of glutamatergic projection neurons during neocortical development. Despite their central role in corticogenesis, the transcriptional mec...
Jinghui Song,Tao Chen,Liang Ma
Jinghui Song
Intervertebral disc degeneration (IVDD) is commonly framed as the cumulative result of extracellular matrix loss, inflammatory activation, oxidative damage, cellular senescence and cell death. This formulation is useful, but it also fragmen...