A mitoxyperilysis-related signature stratifies prognosis and identifies an aggressive colorectal cancer ecosystem with immune remodeling [0.03%]
与线粒体DNA删除相关的特征可区分预后并识别具有免疫重塑的结直肠癌生态系统
Yi Zhang,Bin Sun,Joshua Lin et al.
Yi Zhang et al.
Background: Mitoxyperilysis is a recently described lytic cell death pathway linked to innate immune activation and metabolic disruption. Its clinical and biological relevance in colorectal cancer (CRC) remains unclear. T...
Modelling DMC1 mediated homologous recombination repair in mouse embryonic stem cells [0.03%]
小鼠胚胎干细胞中DMC1介导的同源重组修复的建模研究
Aditya Mhaskar,Esther Sleddens-Linkels,Ivy Liang et al.
Aditya Mhaskar et al.
Introduction: Programmed DNA double-strand break (DSB) formation and repair are central to meiotic homologous chromosome pairing in mammals. In meiotic cells, the DSB repair mechanism is modified compared to mitotic cells...
Microbiome and cancer: mechanistic insights, diagnostic potential, and therapeutic strategies [0.03%]
微生物组与癌症：作用机制、诊断潜力和治疗策略
Vivek Kumar,Amit Chaudhary,Mansi Gautam et al.
Vivek Kumar et al.
The human microbiome is now recognized as an active and dynamic participant in cancer biology rather than a passive bystander. Increasing evidence demonstrates that microbial dysbiosis contributes to tumor initiation and progression through...
From vascular normalization to VEGF-independent escape: multi-omics-defined angio-immune ecosystem states [0.03%]
从血管正常化到VEGF非依赖性逃逸：多组学定义的血管免疫生态系统状态
Baolai Li,Haitao Song,Yongmei Dai et al.
Baolai Li et al.
Anti-angiogenic therapy and immune checkpoint blockade can synergize, yet benefits are frequently transient, implying that resistance reflects ecosystem-level reprogramming rather than failure of a single pathway. Here we define angio-immun...
Nucleophosmin 1 proteins as potential therapeutic targets in non-communicable chronic inflammatory diseases: a review of pathophysiological mechanisms [0.03%]
核糖体磷蛋白S3作为非传染性慢性炎症疾病治疗靶点的潜在作用机制综述
Kaijie Wen,Tao Hu,Qiang Wang et al.
Kaijie Wen et al.
Nucleophosmin1 (NPM1) proteins, initially recognized as central guardians of nucleolar architecture and function, have recently been redefined as pivotal hubs that integrate diverse forms of chronic cellular stress signaling. Although the r...
Anthony Valverde,Asok K Dasmahapatra
Anthony Valverde
TAF7 accumulates in the cytoplasm during cellular transformation and engages STAT3, WASH, and CCT [0.03%]
TAF7在细胞转化过程中累积于细胞质中并与STAT3、WASH和CCT相互作用
Dan Cheng,Elizabeth McManus,Ryan M Young et al.
Dan Cheng et al.
TAF7, a core subunit of the general transcription factor TFIID, regulates transcription and additionally functions as an RNA chaperone that directs nascent nuclear RNAs to cytoplasmic polysomes, thereby influencing protein synthesis. Here, ...
Modeling Alzheimer's disease with brain organoids: mechanisms, applications, and future directions [0.03%]
人脑类器官模型模拟阿尔茨海默病：机制、应用和未来方向
Qing Zhao,Songtao Li,Yanxiu Ju et al.
Qing Zhao et al.
Human pluripotent stem cell-derived brain organoids have emerged as a transformative platform for modeling Alzheimer's disease (AD), thus addressing long-standing translational obstacles posed by the disease's complex etiology and interspec...
Association between acupuncture and IVF outcomes in women with poor ovarian response: a retrospective cohort study [0.03%]
针刺与卵巢反应差女性的体外受精结局之间的关系：一项回顾性队列研究
Jia Liu,Ran Ji,Xiaoyan Zheng et al.
Jia Liu et al.
Introduction: Poor ovarian response (POR) is a major barrier to in vitro fertilization (IVF) success. We assessed whether adjunctive acupuncture is associated with improved IVF outcomes among women with POR. ...