Sebaceomas in a Muir-Torre-like Phenotype in a Patient with MUTYH-Associated Polyposis [0.03%]
MUTYH错构瘤性 polyposis患者具有类似穆伊 Torre综合征的sebaceoma病例报告
Julia Guarrera,James C Prezzano,Kathleen A Mannava
Julia Guarrera
This case report describes a case of a patient with MUTYH-associated polyposis (MAP), who presented with multiple sebaceomas in a Muir-Torre-like phenotype. MAP is caused by mutations in MUTYH, a base excision repair gene responsible for de...
Claudin-4 Upregulation in Acantholytic and Autoimmune-Mediated Bullous Disorders [0.03%]
Claudin-4在表皮松解性皮肤病和自身免疫性大疱性皮肤病中的表达上调
Chau M Bui,Huy G Vuong,Minh-Khang Le et al.
Chau M Bui et al.
Claudin-4 is a key component of tight junctions, which play an important role in the formation of the epidermal barrier by forming a circumferential network in the granular layer that serves as a gatekeeper of the paracellular pathway. The ...
Kinase Fusions in Spitz Melanocytic Tumors: The Past, the Present, and the Future [0.03%]
Spitz黑素细胞肿瘤中的激酶融合：过去、现在和未来
Maged Daruish,Francesca Ambrogio,Anna Colagrande et al.
Maged Daruish et al.
In recent years, particular interest has developed in molecular biology applied to the field of dermatopathology, with a focus on nevi of the Spitz spectrum. From 2014 onwards, an increasing number of papers have been published to classify,...
Asghar Shah,Samer Wahood,Dorra Guermazi et al.
Asghar Shah et al.
This literature review introduces the integration of Large Language Models (LLMs) in the field of dermatopathology, outlining their potential benefits, challenges, and prospects. It discusses the changing landscape of dermatopathology with ...
Andrea Michelerio,Antonio Greco,Dario Tomasini et al.
Andrea Michelerio et al.
Galli-Galli disease (GGD) is a rare genodermatosis that exhibits autosomal dominant inheritance with variable penetrance. GGD typically manifests with erythematous macules, papules, and reticulate hyperpigmentation in flexural areas. A dist...
Amun Georg Hofmann,Julia Deinsberger,André Oszwald et al.
Amun Georg Hofmann et al.
Ulcerations of the lower extremities are a frequently encountered problem in clinical practice and are of significant interest in public health due to the high prevalence of underlying pathologies, including chronic venous disease, diabetes...
Direct Immunofluorescence of Skin and Oral Mucosa: Guidelines for Selecting the Optimum Biopsy Site [0.03%]
皮肤和口腔粘膜的直接免疫荧光检测：选择最佳活检部位的指南
Muhammad N Mahmood
Muhammad N Mahmood
Direct immunofluorescence is a vital diagnostic test for assessing vesiculobullous disorders, vasculitides, and connective tissue diseases. It is a robust and valuable technique that offers essential diagnostic information for many critical...
Diagnosing Cutaneous Melanocytic Tumors in the Molecular Era: Updates and Review of Literature [0.03%]
分子时代皮肤黑素细胞肿瘤的诊断：文献回顾与更新
Chelsea Huang,Tiffany Wing-See Lau,Bruce R Smoller
Chelsea Huang
Over the past decade, molecular and genomic discoveries have experienced unprecedented growth, fundamentally reshaping our comprehension of melanocytic tumors. This review comprises three main sections. The first part gives an overview of t...
Ramona Tasar,Melanie Peckruhn,Jörg Tittelbach
Ramona Tasar
Folliculosebaceous cystic hamartoma (FSCH) is a rare and benign form of cutaneous hamartomas. These skin lesions often lead to clinical and histopathological misdiagnosis due to their similarities to cutaneous lesions with overproduction of...
A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus [0.03%]
多形性皮肤肉瘤一例：内眦部的巨大外生肿瘤
Rylee Moody,Kavita Darji,Tricia A Missall et al.
Rylee Moody et al.
We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells w...